Sepsis Diagnosis and Treatment

International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium

The paper identifies a novel framework to quantify immune dysregulation in critical illness by analyzing transcriptomic data across multiple cohorts.

Platelet factor 4 modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes

This study identifies platelet factor 4 (PF4) as a mediator of endothelial antimicrobial activity, enhancing bacterial clearance and improving sepsis outcomes through clathrin-mediated endocytosis and reduced immunothrombosis.

Biological landscape of acute illness in children in sub-Saharan Africa and South Asia

The paper identifies common and syndrome-specific omics responses to acute illness in children and shows how malnutrition modifies host responses.

Citrate synthase improves sepsis-induced lung injury by reconstructing the mitochondrial tricarboxylic acid cycle of macrophages

This study shows that citrate synthase reduces sepsis-induced lung injury by restoring mitochondrial TCA cycle function in macrophages.

The circulating cell-free DNA landscape in sepsis is dominated by impaired liver clearance

This study analyzes cfDNA in sepsis patients, finding increased levels due to impaired liver clearance rather than immune cell death, and identifies liver and megakaryocyte-erythroid progenitor contributions.

Advanced Age in Mice Exacerbates Sepsis-Induced Inflammation, Vascular Permeability, and Multi-Organ Dysfunction

This study shows that older mice experience more severe sepsis with higher inflammation, vascular permeability, and organ damage compared to younger mice.

Cross-species biomarkers of cerebellar injury in acute sepsis: integrated metabolomics of mouse cerebellum and plasma identify conserved human plasma biomarkers and therapeutic modulation by human MSC-sEVs

The paper identifies cross-species plasma biomarkers for septic encephalopathy using metabolomics in mice and humans, and shows therapeutic effects of MSC-sEVs.

A conserved immune dysregulation is associated with infection severity, risk factors prior to infection, and treatment response

The paper identifies a conserved immune signature linked to infection severity, risk factors, and treatment response using multi-cohort transcriptomic and proteomic data.

Multimodal Analysis of Sepsis-induced Cardiomyopathy in a Baboon Model

This study uses a baboon model of sepsis to analyze cardiomyopathy through multimodal techniques, finding distinct transcriptomic and physiological differences between survivors and non-survivors.

Rare variants in infection response protein pathways associated with sepsis in children.

The paper identifies genetic pathways and variants associated with sepsis susceptibility in children through genomic analysis of a paediatric cohort.

Genome-wide association study of pediatric bacteremia and sepsis

This paper identifies a genetic locus associated with sepsis susceptibility in children using a genome-wide association study of a national cohort.

A bioenergetic basis for multiorgan dysfunction in sepsis

This study identifies adipocyte lipolysis as a critical metabolic process that prevents sepsis in mice by supporting energy metabolism and thermoregulation through insulin signaling, without affecting bacterial burden.

Structural and temporal dynamics analysis on PANoptosis in sepsis: a bibliometric analysis

This study performs a bibliometric analysis of PANoptosis in sepsis research from 2000 to 2024, identifying key themes, trends, and emerging subfields.

Branched-chain ketoacid antioxidants mediate disease tolerance to sepsis

The paper identifies branched-chain ketoacids (BCKAs) as antioxidants that improve survival in sepsis by neutralizing hydrogen peroxide and preventing lipid peroxidation, without affecting bacterial clearance.

T cell memory alters pulmonary inflammatory responses to cecal ligation and puncture.

This study shows that preexisting T cell memory in mice alters the inflammatory response to cecal ligation and puncture, mimicking aspects of human sepsis-related lung injury.

Determining potential immunomodulatory drug efficacy in sepsis using ELISpot

This study uses ELISpot to assess immunomodulatory drug effects on cytokine production in sepsis patients and healthy controls.

High-throughput RNA and Single-cell RNA Sequencing to Identify Sepsis associated Molecular Mechanisms and the Blood Immune Cell Landscape

This study identifies sepsis subtypes and key genes through bioinformatics analysis of RNA and single-cell RNA sequencing data, highlighting lactate metabolism and immune cell changes.

Mechanistic Study of palmatine in Regulating Pyroptosis in Sepsis Cells via Signaling Pathways

This study investigates whether palmatine affects sepsis-related pyroptosis through signaling pathways, finding partial overlaps between palmatine pathways and those in sepsis pyroptosis.

Partial Wwox Loss of Function Increases Severity of Murine Sepsis and Neuroinflammation

The paper shows partial Wwox loss of function in mice worsens sepsis severity and neuroinflammation.

Comparative immuno-biology at clinical recognition of early multiple organ dysfunction syndrome in pediatric and adult patients using single-cell transcriptomics

The paper uses single-cell transcriptomics to identify S100 gene expression patterns and cell-type changes in MODS patients, showing diagnostic potential and therapeutic implications.

scCaT: an explainable capsulating architecture for sepsis diagnosis transferring from single-cell RNA sequencing

This paper introduces scCaT, a deep learning framework combining capsulating architecture and Transformer for sepsis diagnosis using single-cell RNA sequencing data and transferring to bulk RNA data, achieving high accuracy and explainability.

Delineating the Role of ITGAM in Macrophage Dynamics and Cardiac Modulation during Sepsis-Induced Cardiomyopathy

The paper identifies ITGAM as a key modulator in macrophage dynamics during sepsis-induced cardiomyopathy and shows its dual role in inflammation and cardiac recovery.

Integrated Analysis Reveals Immunogenic Cell Death in Sepsis-induced Cardiomyopathy

This paper identifies immunogenic cell death (ICD) as a key factor in sepsis-induced cardiomyopathy (SIC) using scRNA-seq and RNA-seq data, and develops an SVM model for SIC diagnosis.

A transient brain endothelial translatome response to endotoxin is associated with mild cognitive changes post-shock in young mice

Mitochondrial transplantation and its impact on infectious disease progression: a pilot study

This pilot study investigates the impact of mitochondrial transplantation on infectious disease progression in mice, finding improved survival and reduced inflammation in sepsis models but not in influenza models.

Bioinformatics and next generation data analysis reveals the potential role of inflammation in sepsis and its associated complications

The paper identifies differentially expressed genes and pathways in sepsis using NGS data, highlighting potential hub genes and regulatory elements involved in sepsis progression.

An aiHumanoid Simulation of Gram-Negative Sepsis: A Comprehensive Multi-Organoid Platform for Advanced Disease Modeling, Drug Discovery, and Personalized Medicine.

This study develops and validates an AI-based multi-organoid simulation called aiHumanoid to model gram-negative sepsis effects across multiple organ systems and evaluate its potential for drug discovery and personalized medicine.

A pharmacoproteomic landscape of organotypic intervention responses in gram-negative sepsis

This study uses pharmacoproteomics to analyze treatment responses in a murine sepsis model, identifying distinct response patterns and drug interactions across organs and time.

Ziqi Dihuang decoction ameliorates thrombosis in septic rats by inhitbiting plasminogen activator inhibitor-1

This study shows Ziqi Dihuang decoction reduces inflammation and improves coagulation in septic rats by lowering PAI-1 levels.

Association between APOL1 risk variants and the occurrence of sepsis in Black patients hospitalized with infections: a retrospective cohort study

This study investigates the association between APOL1 risk variants and sepsis occurrence in Black patients with infections, finding that the increased risk is largely due to pre-existing severe renal disease.