Posttraumatic Stress Disorder Research

Meta-analysis of longitudinal epigenome-wide association studies of military cohorts reveals multiple CpG sites associated with post-traumatic stress disorder

The paper performs a meta-analysis of DNA methylation data from military cohorts to identify CpG sites and regions associated with PTSD development.

Effective psychological treatment for PTSD changes the dynamics of specific large-scale brain networks

This study shows that effective cognitive therapy for PTSD restores balance in brain networks involved in self-referential processing and threat detection.

Individual Prediction of Psychotherapy Outcome in Posttraumatic Stress Disorder using Neuroimaging Data

The paper uses neuroimaging data to predict psychotherapy outcomes in PTSD, identifying specific resting-state networks that distinguish responders from non-responders.

Neuroanatomical Risk Factors for Post Traumatic Stress Disorder (PTSD) in Recent Trauma Survivors

The paper investigates how hippocampal volume and Cavum Septum Pellucidum (CSP) volume interact to predict PTSD symptom severity and progression in trauma survivors.

Perceived threat bias and reduced hippocampal volume in combat veterans

The paper examines the relationship between perceived threat bias, PTSD symptoms, and hippocampal volume in combat veterans, finding an inverse correlation between perceived threat bias and hippocampal volume.

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

This study identifies genetic loci associated with PTSD and its symptoms using a large veteran cohort, showing high genetic correlations between symptom sub-domains and potential drug targets.

Posttraumatic Stress Disorder and the Social Brain: Affect-Related Disruption of the Default and Mirror Networks

This study investigates social cognitive impairments in PTSD using fMRI, finding hyperactivation to emotional stimuli in social brain networks, linked to symptom severity and training outcomes.

Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group

This study identifies hippocampal subfield volume differences in PTSD and depression across 31 cohorts, finding depression has a stronger effect than PTSD, especially in CA1, with comorbid cases showing more pronounced changes.

Development of PTSD-like behavior in adult mice after observing an acute traumatic event

This study shows that observing an acute traumatic event in mice leads to long-term behavioral and physiological changes, with social relationships playing a key role in the development of PTSD-like behaviors.

Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium

This study identifies reduced fractional anisotropy in the tapetum region of the corpus callosum in PTSD patients using a large multi-cohort analysis of diffusion MRI data.

Methylomic profiles reveal sex-specific shifts in leukocyte composition associated with post-traumatic stress disorder

The paper identifies sex-specific changes in monocyte proportions in males with PTSD using methylomic data, showing no such changes in females.

Individual variability in behavior and functional networks predicts vulnerability using a predator scent model of PTSD

This study shows that pre-trauma neural circuit function predicts individual differences in threat response and vulnerability to PTSD-like behaviors in rats.

microRNA regulation of persistent stress-enhanced memory

The paper identifies mir-135b-5p as a regulator of persistent stress-enhanced memory and a potential therapeutic target and biomarker for PTSD.

Neural oscillations while remembering traumatic memories in PTSD

This study examines neural oscillations in PTSD patients during traumatic memory recall using MEG, finding distinct patterns compared to healthy controls.

The divergent effects of CDPPB and cannabidiol on fear extinction and anxiety in a predator scent stress model of PTSD in rats.

This study tests CDPPB and CBD on fear extinction and anxiety in a PTSD rat model, finding CDPPB enhances extinction without increasing anxiety, while CBD reduces anxiety in susceptible rats.

Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies novel methylation loci

This study identifies ten novel methylation loci associated with PTSD through a meta-analysis of 1,896 cases and controls across ten cohorts, highlighting the AHRR locus and its link to kynurenine levels.

Analysis of Genetically Regulated Gene Expression identifies a trauma type specific PTSD gene, SNRNP35

The paper identifies SNRNP35 as a trauma type-specific PTSD gene through analysis of genetically regulated gene expression in PTSD cases and controls.

A common neural substrate for elevated PTSD symptoms and reduced pulse rate variability in combat-exposed veterans

The paper investigates the relationship between PTSD symptoms, pulse rate variability, and ventromedial prefrontal cortex activation in combat-exposed veterans, finding associations between reduced HF-PRV and impaired vmPFC function.

Adaptive Identification of Cortical and Subcortical Imaging Markers of Early Life Stress and Posttraumatic Stress Disorder

This study uses a machine learning method to identify neuroimaging markers of PTSD and ELS in veterans, finding that combinatorial features improve classification accuracy.

Resting-State Brain Fluctuation and Functional Connectivity Dissociate Moral Injury from Posttraumatic Stress Disorder

The paper investigates neural differences between moral injury and PTSD using resting-state fMRI, finding distinct associations with brain fluctuations and functional connectivity.

PTSD Biomarker Database: Deep Dive Meta-database for PTSD Biomarkers, Visualizations, and Analysis Tools

The PTSD Biomarker Database compiles over 900 PTSD biomarkers from 109 studies to enable exploration and comparison of biomarker findings through interactive visualizations.

Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment

This study examines changes in brain connectivity in PTSD patients after treatment, finding reduced salience network connectivity with PCT and increased central executive network connectivity with CPT.

Economic status mediates the relationship between educational attainment and posttraumatic stress disorder: a multivariable Mendelian randomization study

This study uses genetic data to show that educational attainment causally reduces PTSD risk, with economic status mediating this relationship.

Mechanistic insights on metabolic dysfunction in PTSD: Role of glucocorticoid receptor sensitivity and energy deficit

The paper uses a systems biology approach to analyze how glucocorticoid receptor sensitivity and energy deficit contribute to metabolic dysfunction in PTSD.

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

Genome wide association study of hippocampal subfield volume in PTSD cases and trauma-exposed controls

The paper conducts a GWAS of hippocampal subfield volumes in PTSD cases and trauma-exposed controls, identifying genetic associations and gene-environment interactions.

Smaller Hippocampal CA-1 Subfield Volume in Posttraumatic Stress Disorder

This study finds smaller left hippocampal CA1 volume in PTSD patients compared to trauma-exposed controls, with associations dependent on covariates.

Accelerated DNA methylation aging and increased resilience in veterans: the biological cost for soldiering on

This study finds that veterans with PTSD show no difference in DNA methylation age acceleration compared to non-PTSD veterans, but higher resilience scores are associated with increased DNAm age acceleration.

Aberrant brain response after auditory deviance in PTSD compared to trauma controls: An EEG study.

This study uses EEG to compare brain responses to auditory deviants in PTSD patients and trauma-exposed controls, finding enhanced mismatch negativity and altered theta/alpha power in PTSD.

PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways Across Biological Sex And Modes Of Trauma

This study identifies shared and sex-specific inflammatory pathways in PTSD through a meta-analysis of blood transcriptomes across different trauma types and biological sexes.