Systemic Lupus Erythematosus Research

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1

This study shows that LSP1 deficiency in B cells leads to myeloid-like traits and autoantibody production, accelerating lupus in mice and correlating with reduced LSP1 in lupus patients.

MEK1/2 and ERK1/2 mediated lung endothelial injury and altered hemostasis promote diffuse alveolar hemorrhage in murine lupus

This study shows that MEK1/2-ERK1/2 inhibition prevents diffuse alveolar hemorrhage in lupus-prone mice by reducing endothelial injury and restoring hemostasis.

Systemic autoimmune disease patients' blood immunome reveals specificities and commonalities among different diagnostic entities

The paper uses immunophenotyping to identify patient subgroups in systemic autoimmune diseases, revealing shared immunophenotypes and cytokine signatures across different diagnoses.

A multilayered post-GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE)

This paper presents a post-GWAS analysis pipeline to identify functional variants and target genes for SLE using integrative genomic and epigenomic data.

XIST ribonucleoproteins promote female sex-biased autoimmunity

This study shows that Xist ribonucleoprotein complexes drive sex-biased autoimmunity in males, leading to autoimmune pathology and reprogramming of immune cells to resemble female patterns.

Fibronectin 1 is a novel biomarker of obstetric antiphospholipid syndrome

The paper identifies Fibronectin 1 as a biomarker for obstetric antiphospholipid syndrome through transcriptomic and protein expression analysis.

Cell-Specific Transposable Element Gene Expression Analysis Identifies Associations with Systemic Lupus Erythematosus Phenotypes

The paper identifies cell-specific transposable element (TE) gene expression associations with SLE phenotypes, finding 731 differentially expressed TEs linked to antiviral pathways and IFN signaling.

A Non-Coding Variant in SLC15A4 Modulates Enhancer Activity and Lysosomal Deacidification Linked to Lupus Susceptibility

Genome-wide Association Clustering Meta-analysis in European and Chinese Datasets for Systemic Lupus Erythematosus identifies new genes

This paper applies a locus-based test called OASIS to GWAS datasets from European and Chinese populations to identify 35 common non-HLA SLE genes and their associated pathways.

The Lupus Epigenome Relates to Genetics, Transcription and Serological Profiles with Dependency on Molecular Subtypes and Informs Drug Discovery

This study identifies epigenetic differences in SLE linked to genetics, transcription, and serology, revealing novel drug targets and pathways.

Region- and variance-based DNA methylation analyses reveal novel disease genes and pathways for systemic lupus erythematosus

The paper identifies disease genes and pathways in systemic lupus erythematosus by analyzing DNA methylation differences in blood cells, finding distinct patterns in T and B cells.

B lymphocytes in Treatment-Naive Pediatric Lupus Patients are Epigenetically Distinct from Healthy Children

The paper identifies epigenetic differences in B cells from treatment-naive pediatric lupus patients compared to healthy children, showing distinct chromatin accessibility patterns and potential regulatory roles in disease.

Interpretable machine learning identifies paediatric Systemic Lupus Erythematosus subtypes based on gene expression data

The paper uses rule-based machine learning to identify gene expression subtypes in paediatric SLE, revealing gene networks associated with disease activity and immune pathways.

STAT3-mediated allelic imbalance of novel genetic variant rs1047643 and B cell specific super-enhancer in association with systemic lupus erythematosus

The paper identifies a novel risk variant rs1047643 and its association with B cell-specific super-enhancer activity in systemic lupus erythematosus through multi-omics analysis.

Cell-type-specific transcriptome architecture underlying the establishment and exacerbation of systemic lupus erythematosus

This study identifies cell-type-specific transcriptomic signatures associated with SLE disease establishment and exacerbation, highlighting their clinical relevance and potential limitations in capturing genetic risk factors.

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and Natural Killer cells in systemic lupus erythematosus

The paper uses single-cell multi-omics to analyze T and NK cells in SLE patients, identifying IFN-driven changes and novel biomarkers.

Integrative transcriptomic analysis of SLE reveals IFN-driven cross-talk between immune cells

This paper identifies IFN-driven cross-talk between immune cell types in SLE using gene expression analysis and a novel integrative method.

Genome-wide discovery of lupus genetic risk variant allelic regulatory activity

The paper identifies 482 SLE risk variants with enhancer activity and characterizes allelic regulatory mechanisms at 27 risk loci using MPRA.

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

This study identifies 38 novel SLE loci and shows genetic heterogeneity across ancestral groups, highlighting antibody production as a potential mechanism for disease disparities.

SLE non-coding Genetic Risk Variant Determines the Epigenetic Dysfunction of an Immune Cell Specific Enhancer that Controls Disease-critical microRNA Expression

The paper identifies a non-coding genetic variant associated with SLE that regulates miR-146a expression through a cell-type specific enhancer.

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases

The paper identifies four molecular clusters in systemic autoimmune diseases using transcriptome and methylome data, showing three stable aberrant patterns and one non-specific cluster.

Meta-analysis of 208,370 East Asians identifies 113 genomic loci and yields new non-immune cell relevant biological insights for systemic lupus erythematosus

This study identifies 113 genomic loci for SLE in East Asians, including 46 novel loci, and highlights non-immune cell-related biological mechanisms.

Ethnicity-specific transcriptomic variation in immune cells and correlation with disease activity in systemic lupus erythematosus

This study identifies ethnicity-specific transcriptomic subgroups in SLE patients using RNA-seq data and correlates them with disease activity.

Extensive fragmentation and re-organization of gene co-expression patterns underlie the progression of Systemic Lupus Erythematosus

This study identifies disease-associated alterations in gene co-regulation patterns in SLE, showing fragmentation and redistribution of co-expression domains correlate with disease activity and biological pathways.

Modeling the IL-2-Teff-Treg system in Systemic Lupus Erythematosus patients: possible mechanism and treatment strategies

The paper constructs a mathematical model of the IL-2-Teff-Treg system in SLE patients to simulate disease progression and identify therapeutic strategies for IL-2 dosing.

Genomic convergence of locus-based GWAS meta-analysis identifies DDX11 as a novel Systemic Lupus Erythematosus gene

The paper identifies DDX11 as a novel SLE gene through genomic convergence of GWAS and gene expression data, showing its repression in SLE and potential as a diagnostic tool.

Personalized Therapy Design for Systemic Lupus Erythematosus Based on the Analysis of Protein-Protein Interaction Networks

The paper analyzes protein expression data from Lupus patients to identify key proteins in their interaction networks and suggests potential drug targets.

Genome-wide genetic risk for SLE and disease severity

This study evaluates genetic risk scores for predicting SLE susceptibility and severity using GWAS data from European and Chinese populations, finding moderate predictive performance and associations with renal disease and age of onset.

Human follicular helper T cell promoter connectomes reveal novel genes and regulatory elements at SLE GWAS loci

This paper identifies functional variants and regulatory elements at SLE GWAS loci using 3D chromatin maps of TFH cells, revealing novel genes and regulatory interactions.

Lupus auto-antibodies act as positive allosteric modulators at NMDA receptors and induce spatial memory deficits

The paper shows that lupus auto-antibodies modulate NMDA receptors and cause spatial memory deficits, with GluN2A subunits being more sensitive to these antibodies.