Circadian rhythm and melatonin

Distinctive properties of cones in the retinal clock and the circadian system

The paper identifies cones as an autonomous oscillator in the retinal network and shows they provide input to the master clock under constant light.

Melanopsin retinal ganglion cell-driven contribution to visual and cognitive brain responses in LHON

The paper investigates the role of melanopsin retinal ganglion cells (mRGCs) in visual and cognitive brain responses in LHON patients using fMRI under different light conditions.

Basal leakage in oscillation: coupled transcriptional and translational control using feed-forward loops

This study uses mathematical models to show that coupling transcriptional and post-translational controls via feed-forward loops improves circadian oscillator robustness against basal leakage.

Circadian clock mechanism driving mammalian photoperiodism

This study identifies the circadian clock mechanism in mammals that drives seasonal responses to photoperiod changes through BMAL2 and EYA3/TSH pathways.

A single-sample circadian biomarker that performs across populations and platforms

The paper develops a 12-gene circadian biomarker from epidermal samples that accurately estimates circadian phase across body sites, ages, sexes, and platforms.

Differential Effects of SUMO1/2 on Circadian Protein PER2 Stability and Function

This study shows SUMO1 and SUMO2 differentially regulate PER2 stability and function through distinct mechanisms affecting circadian rhythms.

Hexosamine biosynthetic pathway integrates circadian and metabolic signals to regulate daily rhythms in protein O-linked N-acetylglucosaminylation

Towards chronomic medicine: Enrichment and linkage of chronotype markers with rare disease associated genes

The paper links chronotype genetic markers to rare disease genes, identifying enrichment in cardiovascular and immune disorders.

Adaptive value of circadian rhythms in High Arctic Svalbard ptarmigan

This study shows that circadian rhythms in Svalbard ptarmigans are essential for seasonal adaptation despite lacking daily rhythms in extreme light conditions.

The cell-autonomous clock of VIP receptor VPAC2 cells drives circadian behaviour

This study shows that VPAC2-expressing cells in the SCN contribute to circadian behavior by influencing the period and robustness of the circadian clock.

TASK-3 Two-Pore Potassium Channels drive neuronal excitability of the circadian clock and entrainment to challenging light environments

This study investigates the role of TASK-3 potassium channels in circadian clock neuronal excitability and behavioral adaptation to challenging light environments using a TASK-3 KO mouse model.

Natural Antisense Transcript of Period2, Per2AS, regulates the amplitude of the mouse circadian clock

This study experimentally shows that Per2AS regulates circadian clock amplitude through a negative feedback loop with Per2, without producing a protein.

A robust and self-sustained peripheral circadian oscillator reveals differences in temperature compensation properties with central brain clocks

The paper investigates temperature compensation in Drosophila circadian clocks, showing that peripheral oscillators overcompensate temperature changes unlike central brain clocks.

A novel bioinformatics approach to reveal the role of circadian oscillations in AD development

This study introduces ESOCVD, a computational platform to detect circadian gene expression patterns in AD using untimed transcriptome data, revealing five circadian alteration patterns in AD patients.

Single adeno-associated virus-based multiplexed CRISPR-Cas9 system to nullify core components of the mammalian molecular clock

The paper develops a CRISPR-Cas9-based AAV system to knock out multiple circadian clock genes and demonstrates its effectiveness in disrupting molecular circadian rhythms in vivo.

TimeTrial: An Interactive Application for Optimizing the Design and Analysis of Transcriptomic Times-Series Data in CircadianBiology Research

TimeTrial evaluates cycle detection algorithms in circadian transcriptomics by analyzing real and synthetic data to optimize experimental design and analysis choices.

Developmental function and state transitions of a gene expression oscillator in C. elegans

The paper characterizes a gene expression oscillator in C. elegans larvae, showing it starts in embryos, arrests transiently, and ceases in adults, operating near a SNIC bifurcation.

Nitric Oxide Mediates Neuro-Glial Interaction that Shapes Drosophila Circadian Behavior

This study identifies nitric oxide as a critical signaling molecule linking circadian pacemaker neurons to locomotor behavior in Drosophila, with glia as a major source of NO.

Altered Affective Behaviors in Casein Kinase 1 Epsilon Mutant Mice

This study examines affective behaviors in mice with mutations in the CSNK1E gene, finding altered anxiety, fear, and depressive-like behaviors that vary by mutation type, sex, and light cycle.

Photoperiod-Induced Neurotransmitter Switching in the Circadian Pacemaker Regulates Hypothalamic Dopamine Expression

The paper shows that photoperiod changes induce neurotransmitter switching in SCN neurons, affecting hypothalamic dopamine expression and circadian behavior.

Distinct components of photoperiodic light are differentially encoded by the mammalian circadian clock

The paper investigates how different components of photoperiodic light influence circadian clock properties through behavioral and SCN measurements.

Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels

The paper shows that transcriptional changes during biological rhythms do not directly affect protein levels, which remain constant due to slow turnover rates and post-translational regulation.

Genome-wide circadian rhythm detection methods: systematic evaluations and practical guidelines

The paper evaluates seven circadian rhythm detection algorithms using empirical datasets and simulations, providing guidelines for selecting methods based on data characteristics.

Less is more: Light sampling via throttled visual phototransduction robustly synchronizes the Drosophila circadian clock in the absence of Cryptochrome

The paper shows that a slow visual phototransduction pathway contributes to circadian clock synchronization in Drosophila without requiring Cryptochrome.

Sleep and circadian phenotype in people without cone-mediated vision

This study examines circadian and sleep phenotypes in individuals with congenital achromatopsia, finding that they maintain regular rest-activity patterns despite severe light sensitivity and reduced daytime light exposure.

Circadian clock neurons maintain phase control over daily behavioral activity patterns under divers environmental conditions

The paper shows that E-neurons in Drosophila regulate evening activity peaks under both light-dark and temperature cycles, suggesting hard-wired function despite environmental changes.

Rev-erba heterozygosity produces a dose-dependent phenotypic advantage in mice

This study shows that partial loss of Rev-erb in mice leads to improved metabolic traits compared to wildtype and knockout mice.

Circadian Rhythm Analysis Using Wearable Device Data: A Novel Penalized Machine Learning Approach

This paper introduces a penalized machine learning method to analyze circadian rhythms from wearable device data and links daily rhythms to motor development in infants.

Actigraphy in brain-injured patients - A valid measurement for assessing circadian rhythms?

This study assesses whether circadian rhythms in brain-injured patients can be accurately measured using actigraphy after correcting for passive movements.

CRY1-CBS binding regulates circadian clock function and metabolism

This study identifies CBS-CRY1 binding as a regulatory mechanism linking circadian rhythms and metabolism, showing that CBS modulates CRY1 activity and vice versa.