Microtubule and mitosis dynamics

UNC-10/SYD-2 links kinesin-3 to RAB-3-containing vesicles in the absence of the motor's PH domain

The paper shows UNC-10/SYD-2 links kinesin-3 to RAB-3-containing vesicles without the motor's PH domain, enhancing transport and strengthening weak motor-lipid interactions.

A phosphate-binding pocket in cyclin B3 is essential for XErp1/Emi2 degradation in meiosis I

The paper identifies a phosphate-binding pocket in cyclin B3 critical for XErp1/Emi2 degradation in meiosis I, preventing premature oocyte arrest.

Specific Mitotic Events Drive Cytoskeletal Remodeling Required for Left-Right Organizer Development

This study shows that specific mitotic events drive cytoskeletal remodeling necessary for Left-Right Organizer development in zebrafish.

MARK2 phosphorylates KIF13A at a 14-3-3 binding site to polarize vesicular transport of transferrin receptor within dendrites

The paper identifies that MARK2 phosphorylates KIF13A to regulate dendritic transport of transferrin receptor-containing vesicles by promoting dissociation from vesicles and preventing axonal transport.

Transient lagging chromosomes cause primary microcephaly

This study shows that transient lagging chromosomes in anaphase, caused by loss of WDR62 and ASPM, lead to impaired cell proliferation and primary microcephaly through Aurora-B-dependent activation of 53BP1 and p21.

PAN2-PAN3 deadenylase activity is selectively required for mitotic robustness under microtubule stress

This study shows that PAN2-PAN3 deadenylase activity is required for mitotic robustness under microtubule stress in yeast and human cells.

Heteroallelic combination of anillin mutants reveals cytoskeletal uncoupling during cytokinesis.

The paper shows that combining two Anillin mutants rescues cytokinesis defects, revealing uncoupled cytoskeletal roles mediated by Anillin's N- and C-termini.

On the critical concentration for net assembly of dynamically unstable polymers

The paper derives expressions for critical concentrations of dynamically unstable polymers, showing how nucleotide hydrolysis and spontaneous nucleation rates affect their assembly.

Dynamic self-association of archaeal tubulin-like protein CetZ1 drives Haloferax volcanii morphogenesis

The paper investigates the role of CetZ1 in Haloferax volcanii morphogenesis, showing that its GTP-dependent self-association and specific structural features are critical for cell shape development.

A Cytological F1 RNAi Screen for Defects in Drosophila melanogaster Female Meiosis

The paper screens for genes affecting Drosophila female meiosis by testing RNAi constructs in germline-specific promoters to identify defects in chromosome congression and Mps1-GFP sequestration.

Low-intensity vibration does not induce changes in microtubule dynamics in vitro

This study investigates whether low-intensity vibration affects microtubule dynamics in vitro and finds no significant changes compared to controls, unlike Taxol treatment.

Wee1 inhibition decouples Cdk1 and Plk1 activities: a role for gradual Cdk1 activation throughout G2 phase.

This study shows that gradual Cdk1 activation during G2 phase coordinates mitotic factor production and CDK1/PLK1 activation, and that WEE1 inhibition disrupts this coordination.

Temporally distinct roles of Aurora A in polarization of the C. elegans zygote

This study identifies distinct roles of Aurora A in regulating PAR protein localization during different stages of the C. elegans cell cycle, explaining varied polarity phenotypes observed in RNAi experiments.

Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells

This study shows that SAS-6 is essential for centriole formation in mouse embryos but not in mouse embryonic stem cells, highlighting context-dependent requirements.

Ran-GTP assembles a specialized spindle structure for accurate chromosome segregation in medaka early embryos

This study identifies a specialized Ran-GTP-driven spindle structure in medaka embryos that ensures accurate chromosome segregation during early cleavage divisions.

The oscillation of mitotic kinase governs cell cycle latches in mammalian cells

This paper shows that dysregulation of CycB:CDK disrupts cell cycle switches, leading to genome doubling, a common event in tumorigenesis.

Conformational states of the microtubule nucleator, the γ-tubulin ring complex

This paper identifies two conformations of the γ-tubulin ring complex (γ-TuRC) using cryo-EM and proposes a model for how conformational changes facilitate microtubule nucleation.

Expression Profile of Primary Microcephaly Genes Cdk5rap2, Cep63 and Their Paralogues Pde4dip, Ccdc67 in Mouse Embryonic and Adult Tissues

Mechanism of outer kinetochore assembly on microtubules and its regulation by mitotic error correction

The paper describes the structure of the budding yeast outer kinetochore complexes and how phosphorylation regulates their stability during mitotic error correction.

A Dynamic population of prophase CENP-C is required for meiotic chromosome segregation

This study shows that CENP-C must be expressed during meiotic prophase to ensure proper chromosome segregation, unlike CID which remains stable without prophase expression.

The cell cycle controls spindle architecture in Arabidopsis by modulating the augmin pathway

The paper identifies CDKB1 and CYCB3;1 as regulators of spindle architecture in Arabidopsis, showing their role in modulating the augmin pathway through phosphorylation of EDE1.

Efficient axonal trafficking of endolysosomes depends on the balanced ratio of microtubule tyrosination and detyrosination

The paper shows that disrupting the balance of microtubule tyrosination and detyrosination in neurons leads to defects in axonal transport and AIS length.

Scale-independent topological interactions drive the first fate decision in the Drosophila embryo

The paper shows that topological spindle-spindle interactions, not internuclear distance, control spindle orientation and nuclear fate in Drosophila embryos.

FMNL2 regulates actin for ER and mitochondria distribution in oocyte meiosis

This study shows FMNL2 regulates actin dynamics, spindle migration, and organelle distribution in mouse oocytes, essential for polar body extrusion and meiosis.

Functional Plasticity in Chromosome-Microtubule Coupling on the Evolutionary Time Scale

The paper identifies a conserved arginine residue in the Dam1 complex subunit Dad2 that is essential for viability in yeast but less so in fungi with regional centromeres, suggesting functional plasticity in chromosome-microtubule coupling.

Insights into human outer kinetochore assembly and force transmission from a structure-function analysis of the KMN network

The paper presents a structural and functional analysis of the KMN network, revealing key interfaces and their role in stabilizing microtubule binding and force transmission during chromosome segregation.

Saccharomyces cerevisiae deficient in the early anaphase release of Cdc14 can traverse anaphase I without ribosomal DNA disjunction and successfully complete meiosis

The paper shows that yeast cells with impaired early anaphase Cdc14 release can complete meiosis without ribosomal DNA disjunction in meiosis I, suggesting this process is not essential for meiosis.

Early zygotic gene product Dunk interacts with anillin to regulate Myosin II during Drosophila cleavage

This study identifies Dunk as a regulator of myosin II during Drosophila cellularization by interacting with anillin to control its localization and function.

Nutritional stress-induced regulation of microtubule organization and mRNP transport by HDAC1 controlled α-tubulin acetylation

The paper shows that HDAC1 regulates α-tubulin acetylation in response to nutritional stress, affecting microtubule dynamics and mRNP transport in Drosophila germline cells.

Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192

The paper identifies CEP192 as a novel disease gene linked to mosaic variegated aneuploidy syndrome with tetraploidy and male infertility through genetic analysis and mouse models.