Microtubule and mitosis dynamics

The Caenorhabditis elegans HAM-1 protein modifies G protein signaling and membrane extension to reverse the polarity of asymmetric cell division

This paper investigates how the HAM-1 protein in C. elegans regulates asymmetric cell division by modifying G protein signaling and membrane extension to reverse polarity in specific neuroblasts.

Actomyosin-driven tension at compartmental boundaries orients cell division independently of cell geometry in vivo

The paper shows that localized actomyosin tension at compartment boundaries orients cell division in Drosophila embryos, independent of cell geometry.

TUBA1A mutations identified in lissencephaly patients dominantly disrupt neuronal migration and impair dynein activity

Bimodal Spindle Orientation Drives Tissue Regularity in a Proliferating Epithelium

The paper shows that cell division orientation in a proliferating epithelium is controlled by distinct mechanisms for apical-basal and planar axes, independent of interphase cell shape.

Suppressor analysis uncovers that MAPs and microtubule dynamics balance with the Cut7/Kinesin-5 motor for mitotic spindle assembly in Schizosaccharomyces pombe

The paper identifies suppressor mutations that counteract the loss of the Kinesin-5 motor Cut7 in S. pombe by balancing microtubule dynamics and MAPs.

Assembly of a Parts List of the Human Mitotic Cell Cycle Machinery

The paper identifies 701 genes associated with human mitotic phases through transcriptomics analysis, including 205 putative cell cycle genes and 53 uncharacterised ones, with some showing novel centrosomal localization or proliferation inhibition.

Dynamics of age-related catastrophic mitotic failures and recovery in yeast

This study uses single-cell imaging to examine age-related genome missegregation in yeast, identifying rDNA expansion as a contributor to mitotic failures and nucleolar breakdown.

BFA1 has multiple positive roles in directing late mitotic events in S. cerevisiae

This study identifies Bfa1's dual role in regulating mitotic exit in S. cerevisiae by both inhibiting and activating the MEN through different mechanisms.

Aneuploidy Promotes Intestinal Dysplasia in Drosophila

This study shows that Drosophila intestinal stem cells tolerate aneuploidy without apoptosis, leading to tissue dysplasia through increased proliferation and lineage skewing.

Experimental and computational framework for a dynamic protein atlas of human cell division

The paper develops a framework to create a dynamic protein atlas of human cell division by integrating 4D imaging data with computational modeling.

Separation and Loss of Centrioles from Primordidal Germ Cells to Mature Oocytes in the Mouse

The paper traces centriole loss in mouse oocytes from primordial germ cells to mature oocytes, showing centriole dissolution begins during follicular recruitment and meiotic resumption.

E-cadherin bridges cell polarity and spindle orientation to ensure prostate epithelial integrity and prevent carcinogenesis in vivo

This study shows that E-cadherin connects cell polarity and spindle orientation in prostate epithelial cells, preventing carcinogenesis.

Tripartite chromatin localization of budding yeast Shugoshin involves higher-ordered architecture of mitotic chromosomes

The paper identifies a tripartite chromatin domain of Sgo1p in budding yeast mitotic chromosomes, coinciding with cohesin localization and higher-order chromatin architecture.

3.7 A cryo-EM structure of the core Centromere Binding Factor 3 complex

The paper determines the atomic structure of the CBF3 complex using cryo-EM and proposes a model for its interaction with centromere DNA.

Tricellular junction proteins promote disentanglement of daughter and neighbour cells during epithelial cytokinesis

The paper shows that tricellular junction proteins facilitate the disentanglement of daughter and neighboring cells during epithelial cytokinesis in Drosophila.

Tripolar mitosis drives the association between maternal genotypes of PLK4 and aneuploidy in human preimplantation embryos

The paper identifies tripolar mitosis as a mechanism causing aneuploidy in human embryos and links it to maternal PLK4 genetic variants.

A robust and tunable mitotic oscillator in artificial cells

This paper develops an artificial single-cell system to study mitotic oscillations, showing sustained oscillations over 30 cycles and highlighting energy supply's role in cell cycles.

Cornelia de Lange Syndrome-associated mutations in Smc1 cause both sister chromatid cohesion and cohesion-independent defects

The paper uses budding yeast to assess the impact of CdLS-associated Smc1 mutations on cohesin function, identifying two classes of mutations with distinct effects on chromosome segregation and cohesion.

N-terminal sumoylation of centromeric histone H3 variant Cse4 regulates its proteolysis to prevent mislocalization to non-centromeric chromatin

This study identifies K65 as a SUMO site on Cse4 and shows that sumoylation regulates its ubiquitin-mediated proteolysis to prevent mislocalization and maintain genome stability.

Cryo-EM shows how dynactin recruits two dyneins for faster movement

The paper shows that adaptors like BICDR1 and HOOK3 recruit two dyneins to dynactin, increasing force and speed compared to BICD2's single dynein recruitment.

A "molecular guillotine" reveals an interphase function of Kinesin-5

The paper introduces a method to create conditional motor protein mutants by inserting a protease cleavage site, demonstrating its use with Kinesin-5 in Drosophila embryos to reveal its interphase function in microtubule stabilization.

An essential post-developmental role for Lis1 in mice

This paper shows that Lis1 is essential for axonal transport in adult mice, with loss of Lis1 causing severe neurological symptoms and death.

Conservation of separase N-terminal domain

The paper reanalyzes sequence conservation of separase's N-terminal domain, identifying a conserved cysteine-rich motif across nematodes and vertebrates.

GFP-Forked, a genetic reporter for studying Drosophila oocyte polarity

The paper develops a genetic reporter, GFP-Forked, to visualize and study oocyte polarity in Drosophila by tracking its asymmetric localization.

Drosophila beta-Tubulin 97EF is upregulated at low temperature and stabilizes microtubules

The paper shows that betaTub97EF, a beta-tubulin paralog, is upregulated at low temperatures in Drosophila and stabilizes microtubules, aiding in temperature acclimation.

Genetic Identification of Novel Separase regulators in Caenorhabditis elegans

This study identifies novel separase regulators in C. elegans through an ENU mutagenesis screen, revealing mutations in pph-5 and hsp-90 that suppress a separase mutant phenotype.

Zebrafish yolk syncytial nuclei migrate along a dynamic microtubule network

The paper analyzes yolk syncytial nuclear migration during zebrafish epiboly and finds nuclei move along a dynamically changing yolk microtubule network rather than being pulled vegetally.

APC/CFZR-1 Controls SAS-5 Levels to Regulate Centrosome Duplication in Caenorhabditis elegans

The paper shows that FZR-1 regulates centrosome duplication in C. elegans by controlling SAS-5 levels through the ubiquitin-proteasome system.

Role of midbody remnant in meiosis II creating tethered polar bodies

The paper investigates the role of the midbody remnant from the first polar body (PB1) in directing the precise site of the second polar body (PB2) emission during meiosis II in ascidian eggs.

Caffeic Acid Phenethyl Ester (CAPE) Inhibits Growth of Chromosomally instable bub1Δ mutant in Saccharomyces cerevisiae

This study shows that CAPE inhibits growth of bub1Δ yeast strains with high chromosomal instability by suppressing chromosome mis-segregation.