Neurogenesis and neuroplasticity mechanisms

Presenilin-dependent ErbB4 Nuclear Signaling Regulates Astrogenesis via PARP1

The paper identifies a novel nuclear signaling pathway involving ErbB4 and PARP1 that regulates astrocyte differentiation during brain development.

Most early-born subplate neurons persist as Layer 6b neurons in the adult mouse neocortex

The paper shows that most early-born subplate neurons persist as Layer 6b neurons in adult mice, challenging the belief that they largely disappear postnatally.

Adaptive brain rewiring after brain injury via adult neurogenesis

This study shows that adult mice can reorganize brain circuits remotely after visual cortex injury, with adult neurogenesis contributing to functional recovery in olfactory processing.

An evolutionarily conserved interferon-responsive oligodendroglial state emerges during white matter aging

The paper identifies an interferon-responsive oligodendroglial state in aging white matter using killifish models, linking it to potential neurodegenerative disease mechanisms.

ASCL1 and OLIG2 Expression Dynamics Control Glial Cell Fate and Regional Diversity in the Dorsal Forebrain

This study shows ASCL1 controls glial cell fate and regional diversity in the dorsal forebrain by regulating OLIG2 expression and maintaining OPCs.

Morphological Hallmarks of White Matter Astrocytes Across Development

This study characterizes the morphological development of white matter astrocytes in mice, showing distinct developmental trajectories and structural features compared to gray matter astrocytes.

Progenitor Timing Shapes NG2-Glia Fate and Oligodendrocyte Differentiation

This study shows that the timing of progenitor labeling affects NG2-glia and oligodendrocyte fates, with E16 progenitors generating more NG2-glia and P0 progenitors favoring oligodendrocyte differentiation.

The cytokinetic midbody mediates asymmetric fate specification at mitotic exit during neural stem cell division

The paper shows the midbody facilitates asymmetric fate determinant activation in Drosophila neural stem cells by releasing determinants after nuclear division but before cell division completes.

Multipotent radial glia sequentially deploy fate-restricted intermediate progenitors to diversify cortical interneurons

Fate mapping in mouse shows two separate MGE radial glia pools; the later pool uses temporal cohorts of fate-restricted basal intermediate progenitors to amplify and diversify cortical interneurons.

New cerebellar nuclei evolve through diversification of excitatory progenitors

The paper shows new cerebellar nuclei evolve through diversification of excitatory progenitors and spatial segregation, with inhibitory neurons incorporated later.

Conserved and divergent programs govern cerebellar output neuron development in zebrafish

This study identifies conserved and divergent developmental programs for cerebellar output neurons in zebrafish, showing shared origins with other vertebrates and unique mechanisms for eurydendroid cell organization.

Notch-independent Her6 contributes to control of neural stem cell maintenance by shifting Notch signaling from lateral inhibition towards lateral induction mode

The paper shows Her6, a Notch-independent factor, shifts Notch signaling from lateral inhibition to lateral induction, aiding neural stem cell maintenance in zebrafish.

Juvenile behavioral alterations and sex-dependent deficits in hippocampal neurogenesis following early-life stress in rats

This study examines early behavioral and neuroplastic changes in juvenile rats exposed to early-life stress, finding male-specific deficits in hippocampal neurogenesis and behavioral impairments.

Prenatal exposure to maternal stress drives neurodevelopmental disruptions in the fetal hypothalamus

This study shows that prenatal maternal stress affects fetal hypothalamic neurodevelopment differently in male and female mice, altering transcriptional profiles and cell-cell communication.

Transplantation reveals birthdate-dependent post-mitotic competence in cortical neurons

This study shows that post-mitotic cortical neurons retain birthdate-dependent differentiation potential, with early-born neurons maintaining a broader repertoire than late-born neurons.

Developmental remodeling uncouples neural stem cell function from niche anatomy

This study shows neural stem cells can maintain function outside their normal anatomical niche, revealing plasticity in stem-cell environment relationships.

A Retinoic Acid Autoregulatory Loop Governing Prefrontal-Motor Arealization

The paper identifies an RA-autoregulatory loop in the developing PFC that maintains RA signaling and defines cortical areal identities.

TCF4 Mediates PHF6 Transcriptional Regulation of Neural Stem Cells in the Developing Brain, a Mechanism Disrupted in Börjeson Forssman Lehmann Syndrome (BFLS)

This study identifies TCF4 as a downstream effector of PHF6 in neural stem cell regulation, showing its role in restricting self-renewal and rescuing BFLS phenotypes.

Doublecortin mutation disrupts lattice-dependent proximity to reveal cytoskeletal networks in developing neurons

The paper investigates DCX's role in cytoskeletal networks during neuronal development by analyzing proteomic changes in a disease-associated mutation.

Reduced inhibition of hippocampal adult-born granule cells by parvalbumin interneurons after TBI

This study shows that adult-born granule cells in the hippocampus have reduced parvalbumin interneuron-mediated inhibition after traumatic brain injury, while mature granule cells do not show this deficit.

Astrocyte-oligodendrocyte crosstalk dependent myelination via secreted protein YKL40

This study identifies YKL40 as a secreted protein mediating astrocyte-OPC communication to drive myelination during brain development.

Lifelong Invertebrate Chordate Central Nervous System Regeneration is Driven by a Migrating Pool of Conserved Neural Stem Cells Program

This study identifies a conserved neural stem cell pool driving continuous CNS regeneration in Botryllus schlosseri, showing aging disrupts this process.

Epigenetic perturbation unravels diverse origins, state conversions and de-differentiation of cortical astrocytes

This study investigates the role of DOT1L in astrogenesis, identifying its role in maintaining astrocyte states and revealing multiple origins and state conversions of cortical astrocytes.

FBXW11 Activity Regulates Radial Glial Expansion in Human Cerebral Organoids

The paper identifies FBXW11 as a negative regulator of radial glial expansion and neuronal maturation in human cerebral organoids through CRISPR screening and functional validation.

Coupled transcriptomic divergence establishes a human-specific synaptic glial precursor state

The paper identifies a human-specific synaptic glial precursor state by analyzing single-cell differentiation trajectories across multiple species and shows its role in human cortical evolution.

Parenchymal precursor cells act in concert with canonical neural progenitors to facilitate neural circuit recovery following neuronal loss

The paper identifies a new astrocyte precursor cell population that supports neural circuit recovery after neuronal loss in songbirds.

A single-nucleus regulatory atlas links transposable elements to adult hippocampal neurogenesis

This study uses snATAC-seq and snRNA-seq to identify TE-derived regulatory elements involved in adult hippocampal neurogenesis in response to rhEPO stimulation.

Ligand-binding/transcriptional repressor domain-deficient REV-ERBβ inhibits dendrite and spine formation of newborn adult hippocampal neurons

This study shows that a dominant negative form of REV-ERBβ inhibits dendrite and spine formation in adult hippocampal neurons.

Inhibited oligodendrogenesis, but not repeated mild traumatic brain injury, impairs attention in adult mice

This study shows that impaired oligodendrogenesis, not repeated mild traumatic brain injury, impairs attention in adult mice using a 5-CSRT task.

The transcription factor CLAMP is required for neurogenesis in Drosophila melanogaster.

This study identifies CLAMP as a transcription factor essential for Drosophila NSC differentiation and optic lobe development by regulating Notch and Tailless.