Neurogenesis and neuroplasticity mechanisms

The paper shows OTX2 secreted by the choroid plexus regulates adult neurogenesis by affecting astrocytes and extracellular matrix, reducing newborn neurons in the olfactory bulb.

The paper identifies a novel progenitor cell type, the veil cell, that generates the squamous epithelium in zebrafish embryos through direct transformation and asymmetric divisions.

The paper identifies an Lmx1a-driven Cux2 enhancer in the cortical hem, revealing its role in regulating Cux2 expression in neural progenitors during forebrain development.

The paper shows that deleting GLI2 in cerebellar granule cell precursors does not cause severe cerebellar hypoplasia, as NEPs compensate by replenishing GCPs.

This study examines how motherhood affects hippocampal neurogenesis, microglia, and cytokines in rats, finding both short-term and long-term changes related to aging and cognition.

The paper uses chimpanzee cerebral organoids to identify human-specific genes in cortical development and finds increased PI3K/AKT/mTOR activation in human outer radial glia.

This study shows that the thalamus regulates parvalbumin interneuron development in the mouse prefrontal cortex by controlling Cyp26b1 expression and retinoic acid signaling.

This study shows that Sufu deletion in neural progenitors causes increased proliferation and reduced survival of stem/precursor cells in the dorsal V-SVZ via a Gli3-dependent mechanism.

This study shows that spinal transection injury activates distant hippocampal stem cells via an immune-CNS axis, leading to increased neuron production and improved memory performance.

This study identifies an increase in asymmetric stem cell divisions with age as a key factor in the decline of neurogenesis in adult mice.

This study shows that human-specific ARHGAP11B increases proliferative basal radial glia and expands the neocortex in developing ferrets.

This paper uses computational simulations to show that spatiotemporal growth patterns and architectural differentiation during cortical development can explain observed cortico-cortical connectivity patterns in two species.

The paper shows Pax6 has opposite effects on proliferation-differentiation balance in murine diencephalon and cortex, with Foxg1 mediating these differences.

This study investigates the role of SFTA3 in MGE interneuron specification using CRISPR-generated knockout lines and shows reduced differentiation capacity in SFTA3 KOs compared to NKX2.1 KOs.

The paper shows that indirect and direct striatal neurons intermix through active migration, with Ebf1 mutation disrupting this process and affecting striatal architecture.

The paper shows that enriched environment increases inter-individual variability in brain and behavior traits in mice.

This study identifies sequential waves of oligodendrocyte and NG2 cell fate specification in zebrafish spinal cord through distinct levels of Hedgehog signaling and Notch activity.

This paper identifies continuous cortical regionalization from embryonic stages to old age using longitudinal data and gene expression analysis.

The paper compares adult hippocampal neurogenesis across species by aligning developmental timelines and finds superimposable neurogenesis envelopes when normalized.

This study shows that p53 deletion rescues lethal microcephaly in Kif20b mutants by reducing NSC apoptosis, but not midbody maturation defects.

This study identifies postnatally-generated CR+ PG cells in the olfactory bulb that retain immature properties and limited network participation.

This study shows that ASTN1 binds N-cadherin (CDH2) in cis and trans, forming a bridge complex that supports glial-guided neuronal migration.

This paper describes a protocol for in vivo pulse-labeling of newborn cells in the central nervous system using carboxyfluorescein esters, enabling tracking and isolation for downstream analysis.

The paper identifies regulatory elements and transcription factors involved in GABAergic and cholinergic neuron fate maturation during MGE development.

This study examines the long-term effects of exercise and memantine on adult neurogenesis in male and female rats, finding sex-specific differences in treatment efficacy.

The paper shows E proteins differentially cooperate with proneural bHLH transcription factors to sharpen neurogenesis by acting on specific DNA motifs.

The paper shows that dormant progenitors regenerate Purkinje neurons after injury, but regenerative capacity declines with age.

The paper identifies ZNF367 as an age-regulated zinc finger factor that modulates embryonic neurogenesis and may contribute to age-related decline in neural stem cell function.

The paper uses single-cell transcriptomics to show that embryonic Pdgfra+ cells give rise to OPCs with convergent transcriptional profiles in different CNS regions.