Extracellular vesicles in disease

Astrocyte and mitochondrial footprints in brain-derived extracellular vesicles predict tau pathology

The paper identifies distinct proteomic signatures in brain-derived extracellular vesicles from 3R and 4R tauopathies, linking them to disease-specific cellular and molecular changes.

Integrated Techniques for Extracellular Particle Separation and Single-Particle Multiparametric Characterization to Track Cancer Biomarkers from Tissue to Biofluids

This study uses BEST and MBA to track extracellular vesicle cargo in gastric cancer, showing saliva as the best biofluid for diagnosis.

Piezo ion channel activation increases the release of therapeutic extracellular vesicles after mechanical stimulation in bioreactors

This study shows that activating Piezo1 ion channels via mechanical shear stress increases extracellular vesicle production from adipose-derived stromal cells in bioreactors.

Large extracellular vesicles containing mitochondria (EVMs) derived from Alzheimer disease cells harbor pathologic functional and molecular profiles and spread mitochondrial dysfunctions

This study characterizes large extracellular vesicles containing mitochondria (EVMs) from Alzheimer's Disease cells, showing they carry pathological mitochondrial dysfunction and spread it to recipient cells.

Exosomal miR-145-5p promotes apoptosis of renal tubule epithelial cells through the JNK signalling pathway

This study identifies miR-145-5p as a mediator of renal tubule epithelial cell apoptosis in ARDS via the JNK pathway.

Exosomes derived from highly scalable and regenerative human progenitor cells promote functional improvement in a rat model of ischemic stroke

This study tests exosomes from human progenitor cells in a rat stroke model, showing improved neurological recovery and identifying key miRNAs involved in angiogenesis and anti-inflammatory effects.

Innovations in skin aging: biomimetic exosomes versus natural exosomes

This study compares the effectiveness of biomimetic and natural exosome-containing products on skin aging using in vitro assays, finding natural exosomes from bovine colostrum enhance cell proliferation and wound closure.

Quantitative fluorescent nanoparticle tracking analysis and nano-flow cytometry enable advanced characterization of single extracellular vesicles

This paper standardizes fluorescent analysis of extracellular vesicles using nanoparticle tracking analysis and nano-flow cytometry with reference materials, enabling accurate quantification of marker abundance and heterogeneity.

Deciphering Cargo Contents in Extracellular Vesicles of Candida haemulonii var. vulnera

This study identifies key proteins and miRNAs in EVs from C. haemulonii var. vulnera, revealing their roles in virulence, adaptation, and immune modulation.

Biofilm formation on glycated collagen modulates Streptococcus mutans bacterial extracellular vesicle production and cargo

This study examines how biofilm formation on glycated collagen affects Streptococcus mutans extracellular vesicle production and cargo, showing size, abundance, and protein content changes.

Royal Jelly Derived Extracellular Vesicles Modulate Microglial Nanomechanics and Inflammatory Responses

This study shows that Royal Jelly Extracellular Vesicles (RJEVs) counteract microglial activation by increasing stiffness, reducing motility, and decreasing pro-inflammatory cytokine secretion.

Orally Delivered Milk-Derived Nanovesicles Loaded with Connexin 43 Peptides forTargeted Cardiac Ischemia-Reperfusion Therapy

This paper develops orally deliverable milk-derived nanovesicles loaded with Cx43 peptides to treat cardiac ischemia-reperfusion injury, showing >60% reduction in infarct size in mice.

Intercellular epigenomic signaling during B cell maturation.

The paper investigates the role of B cell extracellular vesicles in maturation, identifying miR-5099 and long non-coding RNAs as key regulators of antibody diversification.

Adipose-derived Mesenchymal Stem Cells and Retinal Pigment Epithelial Cells Interactions in Stress Environment via Tunneling Nanotubes

This study shows that tunneling nanotubes (TNTs) between adipose-derived mesenchymal stem cells (AdMSCs) and retinal pigment epithelial cells (RPE-1) reduce ROS and improve viability under stress.

FLOW CYTOMETRIC PROCEDURES FOR DEEP CHARACTERIZATION OF NANOPARTICLES

This paper optimizes flow cytometry procedures to accurately identify, quantify, and purify extracellular vesicles and virus-like particles by reducing artifacts and improving specificity.

Investigating the impact of fibroblast proximity to a tumor on fibroblast extracellular vesicle production utilizing 3D bioprinted stromal models

This study shows that normal fibroblasts near a breast tumor produce EVs that promote cancer progression, using 3D bioprinted stromal models.

Exosomes for facial repair, regeneration and rejuvenation: comparison between different commercial products

This study compares the in vitro effects of commercial products containing exosomes and plant-derived nanovesicles on facial repair, regeneration, and rejuvenation, finding that only colostrum-derived exosomes showed significant benefits.

Salivary extracellular vesicles isolation methods impact the robustness of downstream biomarkers detection

This study compares EV isolation methods in saliva, showing that co-precipitation is efficient and detects biomarkers missed by whole saliva analysis.

Enhancing oncolytic virotherapy by exosome-mediated microRNA reprograming of the tumour microenvironment.

This study uses oncolytic viruses to deliver miRNA to TAMs, reversing their immunosuppressive activity and improving ovarian cancer immunotherapy efficacy.

Response of Serum-isolated Extracellular Vesicles to Focused Ultrasound Blood-Brain Barrier Opening

This study examines how FUS-BBBO affects EV concentration and content in mice and AD patients, showing increased EV levels and enhanced biomarker detection.

Investigating the Impacts of Sphingomyelinases on Extracellular Vesicle Cargo Sorting

This study investigates how inhibiting sphingomyelinases affects extracellular vesicle cargo sorting in human cells, revealing distinct impacts on RNA and protein content and cellular behavior.

A New Approach to Monitoring Protein Transfer via Extracellular Vesicles

The paper develops a method to track protein transfer via extracellular vesicles using SILAC and mass spectrometry, achieving 62% labeling efficiency but finding no correlation between EV concentration and protein uptake.

Wnt binding to Coatomer proteins directs secretion on exosomes independently of palmitoylation

This study identifies the structural mechanism by which Wnt7a binds to exosomes for secretion, showing it is independent of palmitoylation and involves a dilysine motif interacting with COPB2.

Label-Free Electrochemical Imaging of Single Extracellular Vesicles

This paper introduces a label-free technique to quantify single extracellular vesicles by measuring their electrochemical impedance, enabling differentiation between cancerous and healthy cell-derived vesicles.

Direct Intercellular Vesicle Exchange between Adjacent Cells

The paper discovers a new form of cell-cell communication called DIVE, where vesicles are directly transferred between adjacent cells, potentially enabling nucleic acid exchange and phenotypic synchronization.

Comprehensive Multi-omics Mapping of Vesicle Cargo from Plasma or Novel Tissue Vesicles Reveals Pathological Changes in Cargo with Patient Age

The paper compares extracellular vesicles from young and aged patients and identifies age-related changes in cargo that correlate with cardiovascular disease.

In Vitro Characterization of Extracellular Vesicles from the Medicinal Plant Centella asiatica for Aesthetic Applications

This study characterizes extracellular vesicles from Centella asiatica and shows they reduce oxidative stress, melanin, and inflammation in vitro and in a UVB-induced mouse model.

Characterization and Functional Assessment of Epicardial Secretome: Epicardium-Derived Extracellular Vesicles and Matrix

This study characterizes and functionally assesses epicardial secretome components, showing hypoxic EVs enhance cell proliferation and metabolic responses, while EPIC-ECM promotes endothelial cell growth.

Unveiling miR-451a and miR-142-3p as Prognostic Markers in NSCLC via sEV Liquid Biopsy

This study identifies miR-451a and miR-142-3p as prognostic markers in NSCLC using sEV liquid biopsy, showing their association with treatment response and survival.

Extracellular vesicles from a novel chordoma cell line, ARF-8, promote tumorigenic microenvironmental changes when incubated with the parental cells and with human osteoblasts.