Trypanosoma species research and implications

Exploring T. cruzi IMPDH as a promising target through Chagas Box screening and AVN-944 inhibition

The paper identifies TcIMPDH as a druggable target for Chagas disease and shows AVN-944 has potent inhibition and selectivity in infected cells.

Functional genomics of trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense across multiple time points and tissues

This study compares gene expression in trypanotolerant and trypanosusceptible cattle during trypanosome infection across multiple tissues and time points, identifying immune-related and coagulation genes associated with trypanotolerance.

Evaluation of the vectorial competence of Glossina brevipalpis in the transmission of Trypanosoma congolense-savannah type, in the Matutuine District, Maputo Province, Mozambique

This study evaluates the vectorial competence of Glossina brevipalpis in transmitting Trypanosoma congolense-savannah type, finding it to be a competent biological vector.

Transcriptomic response to different heme sources in Trypanosoma cruzi

This study examines how different heme sources affect gene expression in Trypanosoma cruzi, identifying novel heme-responsive genes and proteins.

Field Evidence of Trypanosoma cruzi Infection, Diverse Host Use and Invasion of Human Dwellings by the Chagas Disease Vector in Florida, USA

The paper reports field evidence of Trypanosoma cruzi infection in Triatoma sanguisuga in Florida, showing human contact and potential for autochthonous Chagas disease transmission.

Trypanosoma brucei from pigs in sleeping sickness foci from Cote Ivoire is structured into clonal and strongly subdivided populations

The paper genetically characterizes Trypanosoma brucei populations in pigs from Cote Ivoire, finding clonal and subdivided structures in Tbb that differ from previous studies.

Cytosol-living Trypanosoma cruzi amastigotes scavenge cholesterol from host ER and Golgi complex

This study shows Trypanosoma cruzi amastigotes scavenge cholesterol from host ER and Golgi through membrane contact sites and endocytosis, supporting their growth.

Nuclear proteome analysis reveals spatial and temporal compartmentalization of metabolic enzymes during Trypanosoma cruzi cell cycle

This study identifies phase-specific nuclear proteome changes in Trypanosoma cruzi during the cell cycle, revealing metabolic enzymes' role in nuclear processes.

Knocking out histidine ammonia-lyase by using CRISPR-Cas9 abolishes histidine role in the bioenergetics and the life cycle of Trypanosoma cruzi.

This study shows that knocking out histidine ammonia-lyase in Trypanosoma cruzi prevents histidine metabolism, affecting energy production and parasite life cycle.

New Histone H4 variant and H2B variant Exhibits Distinct Genomic Locations, Chromatin Affinities, and Dynamics Throughout Life Cycle and Cell Cycle of Trypanosoma cruzi

This study identifies a novel histone H4 variant (H4.V) in Trypanosoma cruzi, showing distinct genomic localization, expression profiles, and chromatin-binding dynamics compared to H2B.V.

Reversal of ATP synthase is a key attribute for cellular differentiation of the Trypanosoma brucei insect forms

This study shows that ATP synthase reversal, regulated by TbIF1, is essential for Trypanosoma brucei differentiation between insect and mammalian hosts.

Chalcogen derivatives for the treatment of African trypanosomiasis: biological evaluation of thio and seleno- semicarbazones and their azole derivatives

The paper evaluates thio- and seleno-semicarbazones and their azole derivatives for treating African trypanosomiasis, finding Se derivatives more active than S analogues and highlighting the importance of combining TbrCATL inhibition with antioxidant activity.

Clinical Trypanosoma cruzi isolates share a common antigen repertoire that is absent from culture adapted strains

The paper sequenced clinical T. cruzi isolates, finding genomic instability and a unique antigen repertoire absent in lab-adapted strains.

Unravelling genetic differentiation between Glossina brevipalpis populations from two distant National Parks in Mozambique

The paper investigates genetic differentiation between Glossina brevipalpis populations in two Mozambican National Parks, finding them to be isolated subpopulations with minimal gene flow.

T7 RNA polymerase-based gene expression from a transcriptionally silent rDNA spacer in the endosymbiont-harboring trypanosomatid Angomonas deanei

The paper develops a new conditional gene expression system in Angomonas deanei using T7 RNA polymerase to enable genetic manipulations without interfering with endogenous transcription.

Genomic organization of Trypanosoma cruzi tRNA genes

The paper investigates the genomic organization of tRNA genes in Trypanosoma cruzi, revealing synteny with Trypanosoma brucei and identifying chromatin insulator-like tRNA genes.

A novel approach to tagging tubulin reveals microtubule assembly dynamics of the axoneme in Trypanosoma brucei

This study uses tagged tubulin to show that Trypanosoma brucei restricts microtubule assembly to the new flagellum during duplication but allows transient reassembly in mature flagella after cell division.

CryoEM structure of the central apparatus of the Trypanosoma brucei flagellum

This study uses cryoEM to reveal the structure of the central apparatus in Trypanosoma brucei flagella, identifying PF16 as a key scaffold and uncovering lineage-specific adaptations.

Stage-Specific MCM Protein Expression in Trypanosoma cruzi: Insights Into Metacyclogenesis and G1 Arrested epimastigotes.

This study examines MCM protein expression and localization in Trypanosoma cruzi during metacyclogenesis and G1 arrest, revealing their role in cell cycle regulation and replication arrest.

TcCARP3 modulates compartmentalized cAMP signals involved in osmoregulation, infection of mammalian cells, and colonization of the triatomine vector in the human pathogen Trypanosoma cruzi

This study identifies TcCARP3 as a regulator of cAMP signaling in Trypanosoma cruzi, essential for osmoregulation, host cell invasion, and vector colonization.

mtTF1: A Novel Factor Involved in Mitochondrial Gene Expression in Trypanosoma brucei

This study identifies and characterizes mtTF1, a novel mitochondrial transcription factor in Trypanosoma brucei, showing its essential role in mitochondrial gene expression and parasite survival.

The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei operates in the gluconeogenic direction in cellulo under in vivo-like conditions

This paper shows that ATP-dependent phosphofructokinase (PFK) in Trypanosoma brucei functions gluconeogenically in vivo, challenging its traditional role in glycolysis.

Beyond a Linear Structure: The Tubular Organization of the Tripartite Attachment Complex and the Functional Role of TAC53

This paper identifies TAC53 as a novel component of the Tripartite Attachment Complex (TAC) in Trypanosoma brucei, revealing its tubular architecture and role in mitochondrial DNA segregation.

An independently tunable dual control system for RNAi complementation in Trypanosoma brucei

The paper introduces a dual inducer system for RNAi complementation in Trypanosoma brucei, enabling independent and tunable regulation of gene expression to study kDNA replication.

Stomoxys flies (Diptera, Muscidae) are competent vectors of multiple livestock hemopathogens

Across nine Kenyan counties, Stomoxys flies fed on 15 vertebrate hosts, carried Anaplasma, Theileria/Babesia and Trypanosoma DNA, and transmitted T. vivax, T. evansi and Theileria mutans to mice.

Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease

This study shows that intermittent posaconazole treatment does not prevent cardiac and digestive tract pathologies in a chronic Chagas disease mouse model, even with high parasite burden reduction.

A novel host-encoded protein, ETP2, plays an important role in endosymbiont division in the trypanosomatid Angomonas deanei

The paper identifies ETP2, a host-encoded protein essential for endosymbiont division in Angomonas deanei, showing its localization and functional role in division and segregation.

Statins do not reduce the parasite burden during experimental Trypanosoma cruzi infection

This study shows statins do not reduce parasite burden in a mouse model of Trypanosoma cruzi infection, suggesting clinical trials for trypanocidal activity are unjustified.

Stochastic variation in surface protein expression diversifies Trypanosoma cruzi infection

This study shows stochastic variation in virulence gene expression in T. cruzi helps diversify infection and evade immune recognition.

Atomistic Insights into gp82 Binding: A Microsecond, Million-Atom Exploration of Trypanosoma cruzi Host-Cell Invasion

This study uses high-resolution computational modeling to uncover new molecular interactions between T. cruzi gp82 and LAMP2, revealing cooperative motions critical for host-cell invasion.