PI3K/AKT/mTOR signaling in cancer

Claspin is required for growth recovery from serum starvation through regulating the PI3K-PDK1-mTOR pathway

This study identifies Claspin's role in growth recovery from serum starvation by activating the PI3K-PDK1-mTOR pathway through interactions with key signaling molecules.

TSC22D4 interacts with Akt1 in response to metabolic and stress signals

This study identifies TSC22D4 as an Akt1-interacting protein regulated by metabolic and stress signals, revealing its role in cellular processes and metabolic homeostasis.

Target of Rapamycin drives unequal responses to essential amino acid depletion in egg laying

The paper investigates how different essential amino acids affect egg production in Drosophila when depleted, finding that methionine and histidine have distinct impacts compared to other amino acids.

Dynamic modelling of the PI3K/mTOR signalling network uncovers biphasic dependence of mTORC1 activation on the mTORC2 subunit Sin1

The paper uses computational models and experiments to show mTORC1 activity depends biphasically on mTORC2 subunit Sin1 and highlights mLST8 as a therapeutic target in breast cancer.

Computational response modeling reveals context dependent Akt activity in luminal breast cancer cells

The paper develops a computational model of IGF1R and InsR signaling to reveal context-dependent Akt activity in luminal breast cancer cells and identifies RPS6K as a key regulator.

Interactions among mTORC, AMPK, and SIRT: A Computational Model for Cell Energy Balance and Metabolism

The paper develops a computational model of ageing signalling pathways to study interactions among mTORC, AMPK, and SIRT, and their impacts on lifespan and health-span.

Inhibition of mTOR signaling by genetic removal of p70 S6 Kinase 1 leads to anxiety-like disorders

This study shows that deleting S6K1 in adult mice causes anxiety-like behaviors and learning deficits, linked to reduced hippocampal neurogenesis and neuronal atrophy.

Nuclear upregulation of PI3K p110β correlates with increased rRNA transcription in endometrial cancer cells

The paper shows that nuclear p110β in endometrial cancer cells increases rRNA transcription and correlates with tumor progression.

DROSOPHILA MTOR COMPLEX 2 PRESERVES MITOCHONDRIAL AND CARDIAC FUNCTION UNDER HIGH FAT DIET TREATMENT

This study shows that mTORC2 protects Drosophila hearts from HFD-induced mitochondrial and cardiac dysfunction by maintaining mitochondrial homeostasis.

Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

The paper identifies alt-RPL36 as a novel regulator of PI3K-AKT-mTOR signaling through interaction with TMEM24, showing its role in modulating PI(4,5)P2 levels and cell size.

Intricate regulation of ribosome biogenesis genes in response to mTORC1 signaling

The paper shows that Crf1p has dual repressor/activator functions in mTORC1 signaling, affecting ribosome biogenesis genes and HMO1 expression.

Muscle specific translational control of Cand2 by mTORC1 regulates adverse cardiac remodeling

The paper identifies Cand2 as an mTORC1-regulated gene that promotes adverse cardiac remodeling when overexpressed, and shows its deletion protects the myocardium.

The mTORC1/S6K/PDCD4/eIF4A axis determines outcome of mitosis.

The paper identifies the mTORC1/S6K/PDCD4/eIF4A axis as critical for determining cell fate during mitotic arrest, showing that disrupting this pathway can enhance the effectiveness of anti-mitotic drugs.

mTOR driven gene transcription is required for cholesterol production in neurons of the developing cerebral cortex

This study identifies mTORC1 as a transcriptional regulator of cholesterol biosynthesis genes in developing neurons, linking mTOR activity to cholesterol production and neurodevelopmental disorders.

Depletion of Ric-8B leads to reduced mTORC2 activity

This study shows that Ric-8B hypomorphism reduces mTORC2 activity in mice, leading to embryonic defects and impaired GPCR/G protein signaling.

Dis3L2 regulates cellular proliferation through a PI3-Kinase dependent signalling pathway

This study identifies Dis3L2 as a regulator of cell proliferation through a PI3-Kinase dependent pathway in both Drosophila and human cells.

Assembly of novel, nuclear dimers of the PI3-Kinase regulatory subunits underpins the pro-proliferative activity of the Cdc42-activated tyrosine kinase, ACK

The paper shows ACK promotes cell proliferation by stabilizing p85 regulatory subunits and forming nuclear dimers, which may contribute to oncogenesis through novel PI3-Kinase regulation.

Dynamic Modeling of Signal Transduction by mTOR Complexes in Cancer

The paper develops a mathematical model to explain how rapamycin differentially inhibits mTORC1 and mTORC2 based on Le Chatelier's principle.

mTORC1-mediated inhibition of 4EBP1 is essential for Hedgehog (HH) signaling and can be targeted to suppress HH-driven medulloblastoma

A Negative Feedback Regulates The Flow Of Signal Through Akt/mTORC1/S6K1 Pathway

The paper demonstrates that negative feedback in the Akt/mTORC1/S6K1 pathway filters phospho-Akt signals, leading to transient phospho-S6K1 activation and differential responses to insulin and IGF-1.