Effects of Radiation Exposure

NATURAL VARIATION IN RADIOTOLERANCE IS ASSOCIATED WITH DIFFERENCES IN INNATE IMMUNE ACTIVITY AND S-PHASE TRANSCRIPTION IN DROSOPHILA MELANOGASTER

This study identifies a major QTL associated with radiotolerance in Drosophila melanogaster and links it to innate immune activity and S-phase transcription.

Extracting Parsimonious Quantitative Predictors of Biological Effectiveness from 'First-Principles' Radiobiology: Application to the Mixed-Quality Problem

This paper reduces a complex radiobiological model to a simpler three-parameter model using MBAM, showing it aligns with known theories and predicts new synergistic effects between radiation types.

Reprogramming of Lipid Metabolism by FLASH Radiotherapy Selectively Protects Radiosensitive Normal Tissues

This study investigates how FLASH radiotherapy reprograms lipid metabolism to protect radiosensitive normal tissues compared to conventional radiotherapy.

XRRA1 acts as a molecular brake on radiation-induced DNA damage signaling and immunogenic cell death in tumor cells.

This study identifies XRRA1 as a molecular brake that limits radiation-induced DNA damage signaling and immunogenic cell death in tumor cells, suggesting it as a potential target for radiosensitization.

FLASH Radiotherapy Mitigates Radiation-Induced Lymphopenia and Prevents Immunosuppression via Chk1-STAT3 Axis Modulation in a Preclinical Thoracic Irradiation Model

This study shows FLASH radiotherapy reduces lymphocyte apoptosis and prevents immunosuppression by modulating the Chk1-STAT3 pathway in a preclinical model.

Differential impact of FLASH and conventional radiotherapy on a pivotal metabolic organ: White Adipose Tissue

This study compares FLASH and conventional radiotherapy effects on white adipose tissue, finding FLASH better preserves tissue function and structure while conventional RT causes metabolic and inflammatory changes.

Circuit-selective cognitive vulnerability to environmental stress: multi-domain assessment of space radiation in both sexes reveals countermeasure trade-offs

This study assesses how space radiation affects cognitive circuits in male and female mice, revealing sex-specific vulnerabilities and trade-offs in neuroprotective interventions.

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

This study shows proton FLASH irradiation preserves gut microbiota and protects intestinal stem cells in mice, with specific microbial taxa linked to reduced radiation toxicity.

Radiation-induced interferon-I response impairs thyroid organoid function

This study identifies IFN-β signaling as a key mediator of radiation-induced inflammation and cell death in thyroid organoids, with dual effects on survival and regenerative potential.

Avasopasem Manganese acts as both a Radioprotector and a Radiomitigator of Radiation-Induced Acute or Late Effects.

This paper demonstrates that Avasopasem Manganese reduces radiation-induced acute and late effects in normal tissues but does not protect tumor cells.

Predicting neutron radiation exposure characteristics from an in vitro human skin model using RNA-seq

This study uses RNA-seq to identify molecular signatures in human skin models that predict neutron radiation exposure and temporal response.

Feeding Drosophila highly radioresistant fungi improves survival and gut morphology following acute gamma radiation exposure

This study shows that feeding Drosophila Aureobasidium pullulans improves male lifespan and gut morphology after irradiation, while Rhodotorula taiwanensis does not provide protection.

Disrupted bone microenvironment and immune recovery following total body irradiation in a murine model

This study investigates the effects of total body irradiation on bone microenvironment and immune recovery in a murine model, finding persistent apoptotic cells and TGF-β1 signaling contribute to impaired bone remodeling.

Transcriptome of the murine duodenum during recovery after a lethal dose of total body irradiation

This study examines transcriptomic changes in the murine duodenum after lethal total body irradiation and NSPP treatment, identifying regenerative gene activation during recovery.

miRNA-mediated cell-to-cell communications boost DNA repair during theRadioadaptative Response

The paper identifies miRNA-mediated cell-to-cell communication via extracellular vesicles that enhances DNA repair during the radioadaptive response.

Ionizing Radiation Shapes Genome Evolution Through Nuclear Abnormalities That Trigger Delayed Proliferative Death

This study links ionizing radiation-induced nuclear abnormalities to delayed proliferative death and genomic instability through single-cell and bulk genome analysis.

Longitudinal multimodal characterization of radiation dermatitis in the C57BL/6J mouse model

This study develops a longitudinal C57BL/6J mouse model of radiation dermatitis, revealing early molecular changes and distinct temporal signatures of inflammation, barrier dysfunction, and fibrosis.

Endothelial CLK2 as a therapeutic target for acute radiation syndrome

This study identifies CLK2 as a therapeutic target for acute radiation syndrome by showing CLK2 inhibitors protect endothelial cells and reverse radiation injury in human organ models.

Long-Term Effects of Radiation Therapy on Cerebral Microvessel Proteome: A Six-Month Post-Exposure Analysis

This study identifies significant proteomic changes in cerebral microvessels six months after radiation therapy, linking them to metabolic dysfunction and potential cognitive impairment.

CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity

The paper shows that CCR2-driven monocyte recruitment reduces radiotherapy-induced intestinal toxicity by enhancing IL-17 production.

Inhibition of neutrophil degranulation by Nexinhib20 delays the development of radiation-induced pulmonary fibrosis

The paper shows that inhibiting neutrophil degranulation with Nexinhib20 delays radiation-induced pulmonary fibrosis without affecting cancer radiotherapy efficacy.

Regional Vulnerability of Cardiac Chambers to Radiotherapy: A Multi-Omics Perspective

This study uses a multi-omics approach to analyze regional differences in cardiac responses to radiation, identifying distinct molecular and structural changes in different heart regions.

Gamma radiation-induced molecular toxicity and effects on pluripotent stem cells of the radiosensitive conifer Norway spruce (Picea abies)

This study assesses the effects of gamma radiation on Norway spruce stem cells, finding dose-dependent DNA damage and transcriptomic changes, but retained stemness despite cellular abnormalities.

Covariation between metabolic and radioactive dose rates in Chornobyl rodents

The paper examines how metabolic rates and aerobic capacity in Chernobyl rodents correlate with radioactive dose rates, finding differing patterns in adults and subadults.

Hypoxia/HIF Signaling Negatively Regulates Bone Marrow Adiposity after Radiation Exposure

The paper shows that loss of HIF signaling in aP2-expressing cells increases radiation-induced marrow adiposity.

Localized FLASH Radiotherapy Reduces Long-Term Skin and Muscle Damage While Preserving Systemic Homeostasis

This study compares FLASH and conventional radiotherapy in melanoma-bearing and naive mice, finding FLASH reduces long-term tissue damage and systemic inflammation while maintaining tumor control.

Correlation between DNA double strand breaks and cell death in peripheral blood lymphocytes from breast cancer patients

The paper examines the correlation between DNA double strand breaks and apoptosis in breast cancer patients' lymphocytes, finding a negative correlation and genetic associations with apoptosis.

Theoretical value of radiation priming for mitigating toxicity in radiation therapy

The paper develops an empirical mathematical model to improve radiation therapy by using radiation priming to increase tolerance to higher therapeutic doses.

Modelling radio-induced peroxidation of membrane lipids at ultrahigh dose-rate with pulsed beam

The paper develops a radio-kinetic model to predict lipid peroxidation and biological outcomes under FLASH radiotherapy conditions, showing correlations with experimental data.

RadiSeq: a single- and bulk-cell whole-genome DNA sequencing simulator for radiation-damaged cell models

RadiSeq simulates single- and bulk-cell whole-genome sequencing of radiation-damaged cell models, validated against experimental data to aid radiation genomics research.