Effects of Radiation Exposure

Genome-wide transcriptomic response of whole blood to radiation

This study uses RNA-seq to analyze gene expression changes in human blood after X-ray exposure, identifying novel radiosensitive genes and pathways.

A human ex vivo model of radiation-induced skin injury reveals p53-driven DNA damage signaling and recapitulates a TGFβ fibrotic response

This study develops a human ex vivo skin model that recapitulates radiation-induced DNA damage and fibrotic responses, identifying p53-driven pathways and potential therapeutic targets.

Radiation exposure induced blood-brain barrier injury via mitochondria-mediated sterile inflammation

This study uses a blood-brain barrier microphysiological system to show radiation induces sterile inflammation via mitochondrial DNA release and cGAS-STING signaling, with potential therapeutic targets identified.

High doses of electromagnetic radiation pre- and post- fertilization produce different developmental outcomes in Xenopus laevis.

This study examines how pre- and post-fertilization X-ray exposure affects Xenopus laevis development, finding varying lethality and anomaly rates based on dose and timing.

MIIST305 mitigates gastrointestinal acute radiation syndrome injury and ameliorates radiation-induced gut microbiome dysbiosis

MIIST305 improves survival and gut health in irradiated mice by restoring microbiota balance and reducing inflammation.

Differentiating unirradiated mice from those exposed to conventional or FLASH radiotherapy using MRI

This study uses MRI to differentiate between unirradiated mice and those exposed to conventional or FLASH radiotherapy, finding distinct brain changes after conventional but not FLASH treatment.

Telomerase mRNA Reduces Radiation-induced DNA Damage of human skin

This study shows that telomerase mRNA reduces radiation-induced DNA damage in human skin cells by enhancing DNA repair and reducing mitochondrial ROS without extending telomere length.

The calculation of the mutation frequency for humans at different proton doses in a mathematical model and estimation of the mutation risks for the space explorations

The paper estimates mutation frequencies in human cells under different proton doses using a combined mathematical model for space exploration risk assessment.

A novel murine tail model for radiation-induced skin injury following localized irradiation at varying doses

This paper establishes a novel murine tail irradiation model to study radiation-induced skin injury, finding dose-dependent fibrosis and dynamic melanin changes.

Radiation dermatitis in the hairless mouse model mimics human radiation dermatitis

This study establishes a hairless mouse model of radiation dermatitis that mimics human disease, showing severe skin injury and specific histopathological markers for preclinical research.

The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: implications for deep space missions, female crews, and potential antioxidant countermeasures

This study examines the long-term behavioral effects of galactic cosmic radiation on female mice and evaluates the protective effects of an antioxidant compound.

Differential biological effect of low doses of ionizing radiation depending on the radiosensitivity in a cell line model

The paper evaluates the differential biological effects of low-dose ionizing radiation on radiosensitive and radioresistant cell lines, finding distinct responses in DNA damage, apoptosis, and gene expression.

Nicotine interacts with DNA lesions induced by alpha radiation which may contribute to erroneous repair in human lung epithelial cells

This study shows nicotine accelerates but makes DNA repair more error-prone in human lung cells exposed to alpha radiation, potentially increasing genomic instability.

Multiwell-based G0-PCC assay for radiation biodosimetry

This paper develops a faster radiation biodosimetry method using G0-PCC with RABiT-II, enabling same-day testing for radiation emergencies.

Early Inflammation and Interferon Signaling Direct Enhanced Intestinal Crypt Regeneration after Proton FLASH Radiotherapy

FLASH proton radiotherapy improves normal tissue toxicity without compromising anti-tumor efficacy by coordinating IFN-I signaling across stromal, immune, and revSC networks.

Mitigation of Fetal Irradiation Injury from Mid-Gestation Total Body Radiation with Mitochondrial-Targeted GS-Nitroxide JP4-039

Maternal administration of mitochondrial-targeted JP4-039 mitigates fetal brain injury and preserves mitochondrial function after mid-gestation radiation exposure.

Radiation-Induced Changes in Energy Metabolism Result in Mitochondrial Dysfunction in Salivary Glands

This study investigates radiation-induced changes in energy metabolism in salivary glands, finding altered glycolytic and oxidative phosphorylation rates and mitochondrial dysfunction over time.

A transgenerational mutational signature from ionizing radiation exposure.

This study finds that paternal exposure to ionizing radiation increases clustered de novo mutations in offspring, suggesting cDNMs as a transgenerational biomarker.

Deciphering the Metabolic Shifts in The Hippocampus of Mice Subjected to Near Low Dose Radiation: Insights from Metabolomics and Integrated Multi-omics

This study investigates the metabolic changes in mouse hippocampus after low-dose radiation exposure using metabolomics and multi-omics integration, identifying altered pathways linked to neurodegenerative diseases.

FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates

This study shows FLASH-RT and CONV-RT produce similar levels and proportions of chromosome translocations and junction structures under various oxygen conditions.

RPRM as a potential preventive and therapeutic target for radiation-induced brain injury via multiple mechanisms

This study shows that RPRM deletion reduces radiation-induced brain injury in mice by targeting multiple mechanisms including DNA damage, neurogenesis, inflammation, and microglial activation.

Proton and alpha radiation-induced mutational profiles in human cells

This study examines mutational profiles in human cells exposed to proton and alpha radiation, finding subtle changes in mutation spectra and distributions but not overall increased mutation rates.

Pelvic irradiation induces behavioral and neuronal damage through gut dysbiosis in a rat model

This study shows that pelvic irradiation in rats causes gut dysbiosis, leading to behavioral changes, intestinal damage, and reduced brain neuronal maturation and plasticity.

Effect of age and sex on gene expression-based radiation biodosimetry using mouse peripheral blood

This study evaluates how age and sex affect gene expression-based radiation biodosimetry in mice, finding that while accuracy varies, age and sex must be considered for effective dose prediction.

Radiation Exposure Determination in a Secure, Cloud-based Online Environment

This paper describes ADCI Online, a secure cloud-based platform for radiation dose estimation using dicentric chromosome assays, achieving results comparable to local systems in under 2 days.

Low dose rate γ-irradiation protects Drosophila melanogaster chromosomes from double strand breaks and telomere fusions by modulating the expression of the esi-RNA biogenesis factor Loquacious.

The paper shows that low-dose rate γ-irradiation reduces chromosome breaks and telomere fusions in Drosophila by modulating Loquacious expression.

Significance of the Wnt canonical pathway in radiotoxicity via oxidative stress of electron beam radiation and its molecular control in mice

This study investigates the role of the Wnt canonical pathway in radiotoxicity via oxidative stress in mice, finding that radiation inhibits the pathway and impairs DNA repair and sperm function.

The p53 transactivation domain 1-dependent response to acute DNA damage in endothelial cells protects against radiation-induced cardiac injury

This study shows that p53 TAD1 regulates the DNA damage response in endothelial cells to prevent radiation-induced cardiac injury.

Mouse Genomic Associations with Ex Vivo Sensitivity to Simulated Space Radiation

The paper identifies genomic associations with ex vivo DNA damage responses to ionizing radiation in mice, highlighting pathway differences across radiation types and timing.

Improved radiation expression profiling in blood by sequential application of sensitive and specific gene signatures

The paper improves radiation exposure detection in blood by addressing confounding factors through enhanced gene signatures.