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An overexpression platform reveals the functional diversity of human KRAB-Zinc Finger Proteins in maintaining cellular homeostasis

The paper identifies functional roles of human KZFPs through overexpression screening and integrative analysis, revealing diverse mechanisms in cellular homeostasis.

Mechanisms controlling the deposition and dynamics of histone variant H2BE

This paper identifies key factors regulating H2BE incorporation, localization, and eviction in neuronal chromatin, revealing chaperones and complexes involved in its dynamics.

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs

This study identifies genetic loci affecting lifespan dynamics, sex differences, and body weight trade-offs in mice using an actuarial approach.

EA-PheWAS: Integrating Phenotype Embeddings with PheWAS for Enhanced Gene-Phenotype Discovery

EA-PheWAS improves gene-phenotype discovery by integrating phenotype embeddings with PheWAS, outperforming conventional methods in detecting associations.

Leveraging cell-type specificity and similarity improves single-cell eQTL fine-mapping

The paper introduces CASE, a Bayesian framework for cell-type-specific and shared eQTL fine-mapping, showing improved performance over existing methods in simulations and real data.

Cohesin Acetylation and ATPase Activity Control Cohesion and Loop Architecture through Distinct Mechanisms

The paper investigates how cohesin acetylation and ATPase activity regulate chromatin loop formation and cohesion in yeast, showing they operate through distinct mechanisms.

Tissue-specific divergence in sex-biased DNA methylation across the lifespan

This study identifies tissue-specific sex-biased DNA methylation changes across the lifespan, showing that age-related methylation changes are widespread but sex effects are rare and tissue-specific.

Comprehensive Characterization of the Promoter Proximal Proteome of Single Copy Locus FOXP2

The paper characterizes the promoter proximal proteome of FOXP2 using proximity labeling and mass spectrometry, identifying 373 enriched proteins and validating IRF2BP2 as a negative regulator of FOXP2 transcription.

Sex stratified analyses enable new genetic insights into brain imaging phenotypes

The paper performs sex-stratified genetic analyses of neuroimaging phenotypes, finding new associations and improving heritability estimates when analyzing males and females separately.

Drosophila Arc1 is required for metabolic resilience and developmental timing during dietary challenges

This study shows that Arc1 in Drosophila regulates metabolic resilience and developmental timing in response to dietary changes by linking insulin signaling to metabolic and developmental gene expression.

The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo

This paper introduces two new Cre systems, roxCre and loxCre, for improved conditional gene targeting and lineage tracing in vivo.

In vivo systematic detection of the outcomes of CRISPR/Cas9 mediated DNA repair in skeletal muscle stem cells

This study systematically profiles CRISPR/Cas9 repair outcomes in skeletal muscle stem cells, revealing both expected and novel large on-target modifications and their regulation by repair pathways.

Replication of 10 novel loci involved in human plasma protein N-glycosylation using MALDI-MS and UHPLC-FD data

The paper replicates ten novel loci associated with human plasma N-glycosylation using MALDI-MS and UHPLC-FD data and identifies potential causal genes.

Distinct Cellular Effects of Myotonic Dystrophy type 2 RAN Tetrapeptides in Drosophila melanogaster

This study investigates the distinct toxic effects of QAGR and PACL peptides in Drosophila, showing they impair nucleolar function and autophagy or alter stress granule dynamics, contributing to DM2 pathogenesis.

Zero-inflated Bayesian factor analysis model with skew-normal priors for modeling microbiome data

The paper introduces a Bayesian factor analysis model with skew-normal priors to improve microbiome data analysis by addressing zero inflation and skewness.

EasyCAPS: A web tool for restriction-based genotyping and rational CRISPR-Cas9 donor design

EasyCAPS is a web tool that integrates dCAPS primer design with CRISPR-Cas9 strategies to improve genotyping and gene editing efficiency.

Combination of engineered cell type-specific promoters and a high-efficiency AAV capsid restores hearing in adult DFNB1 mice model with demonstrated safety in nonhuman primate

This paper demonstrates hearing restoration in adult DFNB1 mice using engineered promoters and an AAV capsid, with safety confirmed in nonhuman primates.

Renal Coenzyme A (CoA) Production from VB5 Fuels Stem Cell Proliferation and Tumor Growth

This study shows that renal CoA production from VB5 supports gut stem cell proliferation and tumor growth in Drosophila, with implications for human cancer.

Characterization of variants associated with Cerebral Small Vessel Disease identifies a functional SNV in Versican

The paper identifies a functional SNV in Versican associated with Cerebral Small Vessel Disease using MPRA and validates its effect on transcriptional activity.

A mdg4 Retrotransposon Screen for X-linked Female Sterile Alleles and its Relationship with the Transcription Factor OVO

The paper screens for X-linked female sterile alleles using mdg4 retrotransposon insertions and finds that while mdg4 preferentially inserts near OVO binding sites, only a subset of sterile alleles result from this mechanism.