A. D'Alessandro

Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes

The paper identifies genetic polymorphisms and metabolite levels in stored red blood cells that correlate with hemolysis and transfusion outcomes.

Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma

This study shows copper drives metabolic remodeling and progression in clear cell renal cell carcinoma by coordinating bioenergy, biosynthesis, and redox homeostasis.

Complete absence of GLUT1 does not impair human terminal erythroid differentiation

This study shows that complete absence of GLUT1 in human erythroid cells does not impair differentiation or membrane properties, but leads to metabolic changes and increased oxidative stress.

Inhibition of Asparagine Synthetase Effectively Retards Polycystic Kidney Disease Progression

This study shows that inhibiting asparagine synthetase (ASNS) with antisense oligonucleotides reduces kidney volume and improves renal function in PKD mice by targeting metabolic pathways.

Lactoylglutathione promotes inflammatory signaling in macrophages

This study shows that lactoylglutathione (LGSH) promotes inflammatory signaling in macrophages by increasing histone lactoylation and chromatin accessibility.

Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patients.

Trans-omics analysis of longitudinal plasma samples from severely injured patients identifies endotypes and trajectories that predict clinical outcomes.

Auxin Exposure Disrupts Feeding Behavior and Fatty Acid Metabolism in Adult Drosophila

This study shows auxin exposure affects adult Drosophila feeding behavior and fatty acid metabolism but not fecundity or progeny survival.

Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients, as a function of therapeutic transfusion and hydroxyurea treatment

This study identifies plasma metabolic signatures in sickle cell disease patients linked to cardiorenal dysfunction and treatment response.

Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexylphthalate (DEHP)

This study shows DEHP exposure impairs cardiac function in rats, with dose- and time-dependent effects on conduction and rhythm.

In vivo evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunction

This study analyzes RBC metabolism in 587 SCD patients to compare Hb SS, SC, and transfused AA RBCs, finding genotype-specific metabolic changes linked to hemolysis and organ dysfunction.

Reticulocytes in donor RBC units enhance RBC alloimmunization

This study shows that reticulocytes in donor RBC units increase alloimmunization rates in mice by enhancing alloantibody levels and proinflammatory responses.

Metabolic Signatures of Performance in Elite World Tour Professional Cyclists

This study identifies metabolic signatures in elite cyclists during training and competition, revealing differences in metabolite profiles between exercise modes and race stages.

Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors

The paper identifies 423 genetic loci associated with 132 metabolites in red blood cells using a genome-wide association study of volunteer blood donors.

Hematopoietic stem cells are a long-term reservoir for trained immunity in a mouse model of chronic autoimmune disease

The paper shows hematopoietic stem cells (HSCs) in a mouse model of chronic autoimmune disease serve as a long-term reservoir for trained immunity, with macrophages derived from them exhibiting increased inflammatory activity and reduced metabolic function.

Cytoplasmic labile iron accumulates in aging stem cells perturbing a key rheostat for identity control

This study shows that aging stem cells accumulate labile iron, disrupting a key regulatory pathway that maintains their identity and function.

Hematologic and systemic metabolic alterations due to Mediterranean type II G6PD deficiency in a novel murine model

This study creates a novel murine model of severe G6PD deficiency by introducing a human mutation, revealing metabolic alterations and hemolytic sequelae similar to humans.

Traumatic Brain Injury Impairs Systemic Vascular Function Through Altered Lipid Metabolism and Disruption of Inward-Rectifier Potassium (Kir2.1) Channels

This study shows traumatic brain injury impairs vascular function by reducing Kir2.1 channel activity through PIP2 depletion caused by increased H2O2 and PLA2 activity.

The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality

This paper investigates the role of the N-terminus of band 3 in red blood cell metabolism and storage quality using genetic models and proteomic analyses, showing its impact on metabolic pathways and transfusion outcomes.

Targeting host glycolysis as a strategy for antimalarial development.

The paper investigates enolase inhibitors' effects on erythrocytes and their implications for antimalarial therapy by examining red blood cell homeostasis and parasite growth.

Maturation of human induced pluripotent stem cell-derived cardiomyocytes for modeling hypertrophic cardiomyopathy

This study develops a method to mature hiPSC-CMs, enabling them to model adult-onset cardiovascular disease like hypertrophic cardiomyopathy.

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

This study identifies a mechanism by which Trisomy 21 increases kynurenine pathway activity through overexpression of interferon receptors, leading to immunosuppression and neurotoxicity in Down syndrome.