A. Wang

On the origin and evolution of the mosquito male-determining factor Nix

This study investigates the origin and evolution of the mosquito male-determining factor Nix across Culicinae subfamily species, finding it originated 133-165 MYA and evolved faster than related factors.

Synergizing algorithmic design, photoclick chemistry and multi-material volumetric printing for accelerating complex shape engineering

The paper introduces a method combining algorithmic design, photoclick chemistry, and multi-material printing to rapidly create complex structures for biomedical applications.

Functional diversification despite structural congruence in the HipBST toxin-antitoxin system of Legionella pneumophila

This study characterizes a conserved TA system in Legionella pneumophila, showing functional divergence from its E. coli counterpart despite structural similarity.

Flap-enabled next-generation capture (FENGC): precision targeted single-molecule profiling of epigenetic heterogeneity, chromatin dynamics, and genetic variation

FENGC enables precise, cost-effective targeted sequencing of genetic and epigenetic features by using flap endonuclease to enrich for specific sequences.

Multiscale Hybrid Fabrication: Volumetric Printing Meets Two-Photon Ablation

This paper introduces a hybrid fabrication method combining volumetric printing and two-photon ablation to create multiscale vasculature-like structures for organ-on-a-chip applications.

The molecular mechanism of chloramphenicol and thiamphenicol resistance mediated by a novel oxidase CmO in Sphingomonadaceae

This paper identifies and characterizes a novel oxidase gene cmO in Sphingomonadaceae that mediates chloramphenicol and thiamphenicol resistance through oxidative inactivation.

SIC50: Determination of IC50 by an optimized Sobel operator and a vision transformer

SIC50 uses a vision transformer and Sobel operator to determine IC50 from phase-contrast images, validated with four drugs and 1536-well plates.

Perfusable Apparatus For Thick-tissue Creation And Growth (patch) Of Cardiac Tissue

The paper develops a bioreactor system using 3D bioprinting and perfusion to create and maintain thick, viable cardiac tissue from iPSCs and fibroblasts.

Contrasting roles of landscape compositions in shaping functional traits of arthropod community in subtropical vegetable fields

The paper evaluates how different habitat compositions affect functional traits of arthropod communities in subtropical vegetable fields, finding that forest and grassland habitats enhance functional diversity while non-brassica plantations and water bodies reduce it.

Inhibitory effects of GT0918 on acute lung injury and the molecular mechanisms of anti-inflammatory response

This study shows GT0918 reduces cytokine release and inflammation in COVID-19 by inhibiting NF-κB and activating NRF2, suggesting its potential for treating both mild and severe cases.

Multi-level force-dependent allosteric enhancement of αE-catenin binding to F-actin by vinculin

This study investigates how multiple cadherin-catenin complexes interact with F-actin under force and how vinculin enhances this interaction, revealing cooperative mechanisms that strengthen cell-cell junctions.

Mechanism of the cadherin-catenin F-actin catch bond interaction

This study identifies the E-cadherin/{beta}-catenin/E-catenin complex's catch bond mechanism with F-actin, showing the ABD's role in force-dependent binding and its impact on cytoskeletal linkages.

Autophagy Increases Occludin Levels to Enhance Intestinal Paracellular Tight Junction Barrier.

This study shows autophagy increases occludin levels, enhancing intestinal tight junction barrier function through ERK1/2 MAPK signaling.

Identification of CDRH3 Loops in the Naive B Cell Receptor Repertoire that Can Be Engaged by Candidate Immunogens

The paper identifies CDRH3 loops in the naive B cell receptor repertoire that can be engaged by candidate immunogens using a combined experimental and computational approach.

Deep parallel characterization of AAV tropism and AAV-mediated transcriptional changes via single-cell RNA sequencing

The paper develops a scRNA-seq pipeline to characterize AAV tropism and transcriptional responses at single-cell resolution, revealing cell-type-specific targeting and gene expression changes.

Supercharged Cellulases Show Reduced Non-Productive Binding, But Enhanced Activity, on Pretreated Lignocellulosic Biomass

This study shows that supercharging cellulase surface charge improves hydrolytic activity on pretreated biomass by reducing non-productive binding.

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

Engineered neuron-targeting, placental mesenchymal stromal cell-derived extracellular vesicles for in utero treatment of myelomeningocele

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

m6A modifications regulate intestinal immunity and rotavirus infection

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

Synergistic Enzyme Mixtures to Realize Near-Complete Depolymerization in Biodegradable Polymer/Additive Blends

This study shows that synergistic enzyme mixtures can achieve near-complete depolymerization of polymer/additive blends by combining random chain scission and processive depolymerization.

Hepatic FGF21 mediates tissue tolerance during bacterial inflammation by preserving cardiac function

This study shows that hepatic FGF21 promotes survival during bacterial inflammation by preserving cardiac function, and its signaling via beta-Klotho is required for this protective effect.

SMOG 2 and OpenSMOG: Extending the limits of structure-based models

This paper introduces SMOG 2 and OpenSMOG, extending structure-based models to handle large biomolecular systems with enhanced customization and integration with OpenMM.

Cell minor-axis length is a critical feature for breast cancer cell migration on straight, wavy, loop and grid microfibre patterns

This study shows that breast cancer cells' migration on microfiber patterns is limited by their minor-axis length, suggesting this feature could guide microfiber design for controlling cell movement.

Structure of Infective Getah Virus at 2.8 A-resolution Determined by Cryo-EM

The paper determines the structure of infective Getah virus at 2.8 Å resolution using cryo-EM, revealing glycosylation, S-acylation sites, and lipid interactions critical for immune evasion and host cell invasion.

Diffuse ions coordinate dynamics in a ribonucleoprotein assembly

The paper presents a model to quantify the impact of diffuse ions on RNP assembly dynamics, showing their role in controlling tRNA movement during translation.

Thermal oscillations enable reshuffling of genetic material in a primitive cell cycle

This paper proposes a primitive cell cycle driven by thermal oscillations that enables genetic material reshuffling in prebiotic fatty acid vesicles, leading to the emergence of functional RNA-containing protocells.

Landscape composition mediates suppression of major pests by natural enemies in conventional cruciferous vegetables

This study shows that increasing semi-natural habitats in conventional cruciferous vegetable fields improves pest suppression by natural enemies, with effects varying by pest type and landscape scale.

Functionalized extracellular matrix scaffolds loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing

This study develops a functionalized ECM scaffold with LXW7-DS-SILY to enhance neovascularization and diabetic wound healing in ZDF rats.

Environment-Dependent Switch between Two Immune Systems against Ralstonia solanacearum Infections in Pepper

This study shows pepper activates two different immune systems against Ralstonia solanacearum under high temperature and humidity, regulated by CaWRKY40 and cytokinins.

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations

The paper identifies a minimal set of mutations required for the function of a HIV bnAb and demonstrates in vitro selection of envelope immunogens that can bind to antibodies with these mutations.