C. Li

DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

Senolytics enhance longevity in Caenorhabditis elegans by altering betaine metabolism

This study identifies betaine metabolism as a key factor in aging in C. elegans and shows that senolytics extend lifespan by increasing betaine levels and enhancing autophagy and antioxidant capacity.

Dia2 formin controls receptor activity by organizing plasma membrane lipid partitioning at the nanoscale

This study identifies Dia2 as a regulator of lipid nanodomain organization at the plasma membrane, impacting JAK/STAT signaling and membrane protein activity.

Dissecting the Impact of Maternal Androgen Exposure on Offspring Health through Targeting the Androgen Receptor in Developmental Programming

This study investigates how maternal androgen exposure affects placental development in a PCOS-like mouse model and identifies trophoblast dysfunction as a key mechanism.

A novel simian adenovirus vectored COVID-19 vaccine elicits effective mucosal and systemic immunity in mice by intranasal and intramuscular vaccination regimens

This paper evaluates a novel simian adenovirus vectored COVID-19 vaccine, showing that intranasal vaccination induces stronger mucosal immunity while intramuscular vaccination enhances systemic immunity, with combined regimens providing long-term protection.

Function-associated scRNA-seq on single lung cancer organoids unravels the immune landscape of tumor parenchyma

The paper uses single-cell RNA sequencing on lung cancer organoids to study the tumor immune microenvironment and identifies key genes and T cell activity factors related to immunotherapy response.

NS2B-D55E and NS2B-E65D Variations are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model

This study identifies NS2B-55 and NS2B-65 variations as responsible for differences in NS2B-NS3 protease activity between JEV genotype I and III using fluorogenic peptide assays.

Deciphering the Cofilin Oligomers via Intermolecular Disulfide Bond Formation: A Coarse-grained Molecular Dynamics Approach to Understanding Cofilin's Regulation on Actin Filaments

This study uses molecular dynamics simulations to explore cofilin dimer structures formed via disulfide bonds and their interactions with actin filaments.

Enhancing Light-Sheet Fluorescence Microscopy Illumination Beams through Deep Design Optimization

This paper optimizes light-sheet fluorescence microscopy illumination beams using deep learning to improve cell detection performance.

Expansion of human hematopoietic stem cells by inhibiting translation

This paper identifies translation inhibitors that enable ex vivo expansion of human hematopoietic stem cells from umbilical cord blood while maintaining their function and enabling gene editing.

LEAFY and WAPO1 jointly regulate spikelet number per spike and floret development in wheat

This study identifies LEAFY and WAPO1 as regulators of spikelet number per spike and floret development in wheat through genetic and molecular interactions.

Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7

This study identifies Hmg20a and Nol9 as host factors restricting L. pneumophila replication by repressing Rab7, which is co-opted by the bacterium via SulF to facilitate phagosome biogenesis.

GRAMD2+ alveolar type I cell plasticity facilitates cell state transitions in organoid culture

The paper identifies GRAMD2+ alveolar type I cells as plastic and capable of transitioning through multiple lung epithelial cell states in organoid culture.

Regulated Cleavage and Relocation of FERONIA Control Immunity in Arabidopsis Roots

Bacteria induce FER cleavage via At2-MMP to trigger localized immunity in Arabidopsis root transition/elongation zones.

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

This study shows that G6PD is critical for redox balance and biosynthesis in LKB1-deficient KRAS-driven lung cancer, but not in KP tumors, and identifies potential therapeutic strategies.

Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae post COVID-19

This study compares single-cell RNA sequencing data from human and mouse PASC samples to identify IFN-γ as a driver of respiratory sequelae post COVID-19.

Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice

This study shows that inhibiting Mst1 in endothelial cells reduces acute lung injury in mice by suppressing inflammatory responses and NF-κB activation.

Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation

The paper shows CAM-A modulators eliminate HBV-infected hepatocytes with high core antigen levels via apoptosis, dependent on de novo core protein translation.

Chemical proteomic approach for in-depth glycosylation profiling of plasma carcinoembryonic antigen in cancer patients

This paper develops a chemical proteomic method to profile site-specific glycosylation of low-abundance plasma CEA in cancer patients, revealing differential glycoforms associated with cancer types and progression stages.

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

This study identifies PCID2 as a novel HIV-1 latency-promoting factor that represses transcription and dysregulates viral RNA processing through its role in the TREX2 complex.

Systems-wide analysis of the ROK-family regulatory gene rokL6 and its role in the control of glucosamine toxicity in Streptomyces coelicolor

The paper identifies RokL6 as a regulator that controls the expression of the MFS transporter SCO1448, which protects Streptomyces coelicolor from glucosamine toxicity by exporting toxic metabolites.

Comparative single-cell regulome reveals evolutionary innovations in neural progenitor cells during primate corticogenesis

The paper compares single-cell regulomes of macaque and mouse neural progenitors with human data to identify evolutionary changes in cortex development.

Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators

This paper demonstrates a label-free, real-time biosensing platform using frequency-locked optical microtoroids to detect membrane binding events at zeptomolar concentrations.

Geranylgeranyl pyrophosphate (GGPP) is associated with hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4

This study shows GGPP promotes hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4, and inhibiting GGPP synthase reduces these effects.

Exploring Degradation of Intrinsically Disordered Protein YAP induced by PROTACs

This study develops PROTACs to degrade YAP, showing effective tumor suppression in cancer cell lines and xenograft models.

Quantitative Learning of Cellular Features From Single-cell Transcriptomics Data Facilitates Effective Drug Repurposing

This study introduces SuperFeat, a framework that uses single-cell transcriptomics data to identify drug targets by modeling adverse cellular states, validated in vitro and in vivo.

NGAL deficiency elicits Hemophilia-like bleeding and clotting disorder

This study shows NGAL deficiency causes Hemophilia-like bleeding and clotting issues by enhancing coagulation and suppressing antithrombin.

Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer

This study shows nuclear speckles vary in cancer, correlate with survival in kidney cancer, and are regulated by HIF-2 through speckle targeting motifs.

Enhanced neutralization of SARS-CoV-2 XBB sub-lineages and BA.2.86 by a tetravalent COVID-19 vaccine booster

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

Female baboon adrenal zona fasciculata and zona reticularis regulatory and functional proteins decrease across the life course

The paper quantifies age-related changes in regulatory and functional proteins in baboon adrenal zonae, finding decreased ZF function and less marked ZR function with age.