P. Kumar

A hierarchical GBP network promotes cytosolic LPS recognition and sepsis

The paper identifies a hierarchical GBP network that regulates cytosolic LPS recognition and sepsis by coordinating caspase-11 and gasdermin D functions.

Specific BRCA and immune configurations determine optimal response to platinum-based chemotherapy in triple negative breast and ovarian carcinomas

This study identifies that BRCA1 promoter methylation (BRCA1meth) leads to adaptive recovery of BRCA1 expression and poorer response to platinum chemotherapy compared to BRCA mutations, while immune signals enhance response in BRCA-proficient cancers.

Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

Fecal Microbiota Transplantation Drives Colonic Expression of Immune Activation Genes in a Mouse Model of Antibiotic Use

This study shows that fecal microbiota transplantation (FMT) in a mouse model of antibiotic use increases microbial diversity and upregulates immune activation genes, particularly those associated with type 2 immunity.

Structure and Mechanism of Hedgehog Acyl Transferase

The paper presents the cryo-EM structure of HHAT, revealing its mechanism for transferring palmitate to SHH and identifying a heme group essential for its function.

Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91-112 & 231-290 regions

This paper investigates the conformational dynamics of SARS-CoV-2 NSP6 protein, focusing on regions 91-112 and 231-290 outside the membrane, using molecular dynamics simulations and reductionist approaches.

Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of the matricellular protein Mindin

This study identifies Snail's role in maintaining stem/progenitor state in skin epithelial cells and carcinomas via Mindin-mediated autocrine signaling.

The IL-33-ILC2 pathway protects from amebic colitis

This study shows that the IL-33-ILC2 pathway protects against amebic colitis by reducing inflammation and promoting tissue repair in mice.

Cellular-level phenotyping of tumor-immune microenvironment (TiME) in patients in vivo reveals distinct inflammation and endothelial anergy signatures

The paper uses in vivo cellular-level imaging to phenotype tumor-immune microenvironments, identifying distinct inflammation and endothelial anergy signatures linked to immunotherapy response.

Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes

This study investigates protein aggregation in SARS-CoV and SARS-CoV-2 proteomes, finding that several SARS-CoV-2 proteins form cytotoxic aggregates via a nucleation-dependent mechanism.

A Facile Alternative Sustainable Process for the Extraction and Purification of Microbial Melanin

This paper introduces a sustainable method using tetrabutylammonium hydroxide to extract and purify microbial melanin from Streptomyces hyderabadensis, achieving higher yields and recyclability compared to conventional methods.

Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

Functionalized extracellular matrix scaffolds loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing

This study develops a functionalized ECM scaffold with LXW7-DS-SILY to enhance neovascularization and diabetic wound healing in ZDF rats.

Environmental Dependence of the Structure of the C-terminal Domain of the SARS-CoV-2 Envelope Protein

This paper investigates how environmental factors affect the conformation of the C-terminal domain of the SARS-CoV-2 envelope protein, showing it transitions between disordered, membrane-bound, and amyloid states.

Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals

This study identifies immunodominant T-cell epitopes in SARS-CoV-2 spike antigen and shows pre-existing T-cell immunity in unexposed individuals, suggesting prior exposure to common viruses like Influenza and CMV.

Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients

This study examines ACE2 and TMPRSS2 expression in gastrointestinal tissues to understand their role in digestive symptoms, diabetes mortality, and disease recurrence in COVID-19.

In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission

This study uses in vivo imaging to show that Siglec-1/CD169 on sentinel macrophages facilitates retrovirus transmission through multiple routes.

Urine single cell RNA-sequencing in focal segmental glomerulosclerosis reveals inflammatory signatures in immune cells and podocytes

This study uses urine single cell RNA-sequencing to identify inflammatory signatures in immune cells and podocytes in FSGS, suggesting potential for non-invasive diagnosis and biomarker discovery.

High Throughput Volume Flow Cytometry (parallel-iLIFE) Resolves Mitochondrial Network On the Go

This paper introduces parallel-iLIFE, a high-throughput volume flow cytometry method that enables real-time analysis of mitochondrial networks in HeLa cells with sub-cellular resolution.

Conformational Dynamics of NSP11 Peptide of SARS-CoV-2 Under Membrane Mimetics and Different Solvent Conditions

This study investigates the conformational dynamics of SARS-CoV-2 nsp11 peptide under different membrane mimetics and solvent conditions, revealing its disordered nature and helical propensity in specific environments.

SARS-CoV-2 NSP1 C-terminal region (residues 130-180) is an intrinsically disordered region

This study investigates the conformational dynamics of SARS-CoV-2 NSP1 C-terminal region in isolation and under different solvent environments, finding it intrinsically disordered with conformational changes induced by SDS, TFE, and DOPC.

Exploring the binding of resveratrol to an oncogene promoter DNA sequence d(CCAATTGG)2 through multispectroscopic, nuclear magnetic resonance and molecular dynamics studies

This study investigates resveratrol's binding to an oncogene promoter DNA sequence using spectroscopic and molecular dynamics methods, revealing it binds to the minor groove near AT basepairs.

Clostridium difficile binary toxin (CDT) is recognized by the TLR2/6 heterodimer to induce an NF-κB response

The paper shows that CDT is recognized by the TLR2/6 heterodimer, leading to NF-κB and MAPK pathway activation in mice during CDI.

Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis

The paper shows that a high fat diet reduces MHC-II expression in intestinal stem cells, promoting tumorigenesis by altering immune recognition.

Disulfiram inhibits M. tuberculosis growth by altering methionine pool, redox status and host-immune response

This study identifies disulfiram as a novel inhibitor of Mtb's methionine biosynthesis, showing anti-tubercular effects through redox disruption and immune modulation.

Climate change and the migration of a pastoralist people c.3500 cal. years BP inferred from palaeofire and lipid biomarker records in the montane Western Ghats, India

This paper infers the migration of the Todas to high elevations in the Western Ghats around 3500 cal. yr BP using palaeofire and lipid biomarker records.

Integrated genomic view of SARS-CoV-2 in India

The paper analyzes SARS-CoV-2 genomic data from India to trace introduction and local transmission, identifying multiple clades and highlighting the need for molecular surveillance.

Biodiversity and Antimicrobial Potential of Bacterial Endophytes from Halophyte Salicornia brachiata

This study isolates and characterizes bacterial endophytes from Salicornia brachiata, identifying bioactive compounds with antimicrobial potential.

The Drosophila EGFR ligand mSpitz is delivered to cytoplasmic capes at sites of non-canonical RNA export on the nuclear envelope via the endosomal system

Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.