X. Chen

Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

This study uses population genomic analyses to identify genomic regions under selection and demographic history of the wheat rust pathogen Pst, revealing adaptation mechanisms and population size changes linked to wheat domestication and agriculture.

Polymerization force-regulated actin filament-Arp23 complex interaction dominates self-adaptive cell migrations

This study develops a multiscale model showing that polymerization force-regulated actin-Arp2/3 interactions enable cells to adaptively migrate through heterogeneous ECMs via opposing feedback mechanisms.

Ferredoxin 1 is essential for embryonic development and lipid homeostasis

This study shows FDX1 is essential for embryonic development and lipid homeostasis, with knockout mice showing embryonic lethality and lipid droplet accumulation.

PRO-LDM: Protein Sequence Generation with a Conditional Latent Diffusion Model

PRO-LDM generates protein sequences with tailored properties using a conditional latent diffusion model, enhancing diversity and design fidelity.

Combined Mek inhibition and Pparg activation Eradicates Muscle Invasive Bladder cancer in a Mouse Model of BBN-induced Carcinogenesis

This study shows that combining MEK inhibition and Pparg activation eradicates muscle-invasive bladder cancer in a mouse model by reversing tumor differentiation and inducing apoptosis.

Pneumatic Nano-Sieve for CRISPR-based Detection of Drug-resistant Bacteria

This paper introduces a nano-sieve device for MRSA purification and detection using CRISPR, achieving a 15x concentration factor and 100 CFU/mL LOD.

A vast repertoire of secondary metabolites influences community dynamics and biogeochemical processes in cold seeps

This study investigates secondary metabolites in cold seep microbiomes using metagenomic, metatranscriptomic, and metabolomic data, revealing diverse biosynthetic gene clusters and their potential ecological roles.

Material Properties of Nonpregnant and Pregnant Human Uterine Layers

This study measures time-dependent material properties of human uterine layers in nonpregnant and third-trimester pregnant tissues using nanoindentation.

Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes

This study identifies how mesoscale DNA features influence APOBEC3A and APOBEC3B deaminase activity and their impact on tumor mutational landscapes.

Characterization of N-glycosylation and its Functional Role in SIDT1-Mediated RNA Uptake

This study maps N-glycosylation sites in SIDT1 and SIDT2 and shows their role in RNA uptake, cell surface expression, and protein stability.

Machine learning assisted health viability assay for mouse embryos with artificial confocal microscopy (ACM)

The paper develops a machine learning tool using artificial confocal microscopy to assess embryo viability by detecting nucleus features and classifying embryos into healthy/intermediate or sick categories.

Modelling collective behavior in groups of mice housed under semi-naturalistic conditions

This study uses an automated system to analyze social behavior in groups of mice, revealing social rules and the impact of neuronal plasticity on social interactions.

Endothelial SARS-CoV-2 infection is not the underlying cause of COVID19-associated vascular pathology in mice

This study shows that endothelial SARS-CoV-2 infection does not significantly contribute to COVID-19-associated vascular pathology in mice.

Sequential colonization events with restricted gene flow in a widespread European carnation species

This study investigates the colonization history of Dianthus carthusianorum using genome-wide SNPs and ABC-RF to reveal sequential East-West colonization events with restricted gene flow.

miRNA-encoded regulatory peptides modulate cadmium tolerance and accumulation in rice

This study identifies miPEP156e, a miRNA-encoded peptide in rice, which enhances cadmium tolerance by modulating ROS and Cd transporter genes.

Breakthrough infection elicits hypermutated IGHV3-53/3-66 public antibodies with broad and potent neutralizing activity against SARS-CoV-2 variants including BQ and XBB lineages

This study identifies hypermutated IGHV3-53/3-66 antibodies from breakthrough infections that broadly neutralize SARS-CoV-2 variants including BQ and XBB.

NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer

This study identifies NSD2 as a key driver of lineage plasticity and castration-resistance in neuroendocrine prostate cancer, showing its inhibition can restore sensitivity to AR inhibitors.

Quasi-Equilibrium State Based Quantification of Biological Macromolecules in Single-Molecule Localization Microscopy

This paper introduces a method to precisely quantify molecular stoichiometry in vivo using single-molecule localization microscopy by analyzing fluorophore detections during the quasi-equilibrium state.

Visualization of syntrophic benzene-fermenting Desulfobacterota ORM2 in a methanogenic enrichment culture using fluorescence in situ hybridization

This study visualizes Desulfobacterota ORM2 cells using FISH, revealing their spatial organization and potential role in growth lag phases in a methanogenic culture.

HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-κB signaling pathway in breast cancer

This study identifies HSPB1 as a driver of chemoresistance in breast cancer by inhibiting ferroptosis and activating NF-κB signaling.

EMDiffuse: a diffusion-based deep learning method augmenting ultrastructural imaging and volume electron microscopy

EMDiffuse enhances volume electron microscopy by using diffusion models to improve resolution and enable isotropic reconstruction of large biological volumes.

High-throughput 3D imaging flow cytometry of adherent 3D cell cultures

This paper develops a high-throughput 3D imaging flow cytometry platform for analyzing spheroid models on hydrogel beads, revealing adhering cells have smaller nuclei with non-round surfaces.

BRD4 directs mitotic cell division by inhibiting DNA damage

This study shows BRD4 is essential for normal cell growth by regulating cell cycle genes and preventing DNA damage during replication and mitosis.

Elucidating the Impact of Bacterial Lipases, Human Serum Albumin, and FASII Inhibition on the Utilization of Exogenous Fatty Acids by Staphylococcus aureus

This study investigates how Staphylococcus aureus utilizes exogenous fatty acids through lipases, human serum albumin, and FASII inhibition, showing effects on lipid composition, membrane fluidity, and antimicrobial susceptibility.

Contact toxicity, antifeedant activity and oviposition preference of osthole against agricultural pests

This study evaluates the contact toxicity, antifeedant activity, and oviposition preference of osthole against three agricultural pests to assess its potential for pest control.

Single-cell transcriptomic analysis of pea shoot development and cell-type-specific responses to boron deficiency

This study uses single-cell RNA sequencing to analyze pea shoot development and cell-type-specific responses to boron deficiency, revealing differential gene expression and developmental impacts.

The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems

The paper uses the GH model to analyze genetic drift in mammalian rDNA genes, finding that fixation times are faster than expected, suggesting stronger drift or adaptive evolution.

Spatial redundancy transformer for self-supervised fluorescence image denoising

This paper introduces SRDTrans, a self-supervised denoising transformer for fluorescence images, achieving state-of-the-art performance in single-molecule and two-photon imaging.

Intestinal microbiota modulates the anti-tumor effect of oncolytic virus vaccine in colorectal cancer

This study shows that intestinal microbiota enhances the anti-tumor effect of oncolytic virus vaccine in advanced colorectal cancer by modulating T-cell activity.