X. Chen

Spatial genomics of AAVs reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo

The paper identifies transcriptional crosstalk between enhancers and promoters delivered by AAVs, showing concatemer formation enables targeted delivery of large genetic cargo for cell-type-specific gene editing.

ARBUR, a machine learning-based analysis system for relating behaviors and ultrasonic vocalizations of rats

ARBUR is a machine learning system that clusters rat ultrasonic vocalizations and detects social behaviors, revealing communication patterns and novel findings in social interactions.

Function-associated scRNA-seq on single lung cancer organoids unravels the immune landscape of tumor parenchyma

The paper uses single-cell RNA sequencing on lung cancer organoids to study the tumor immune microenvironment and identifies key genes and T cell activity factors related to immunotherapy response.

Germ granule compartments coordinate specialized small RNA production

The paper identifies a new subcompartment in C. elegans germ granules that facilitates specialized small RNA production, essential for fertility and RNAi response.

Effects of greening-induced warming and cooling on tree phenology in temperate and boreal forests

This study shows forest greening alters tree phenology by causing earlier spring and autumn events through seasonal biophysical warming and cooling effects.

MICLEAR: Intelligent Molecular Cytology for Intraoperative Margin Assessment of Pancreatic Ductal Adenocarcinoma

MICLEAR uses Raman imaging and machine learning to assess PDAC surgical margins with high accuracy and speed.

Experimental Test of Evolutionary Safety of a CRISPR-Cas9 Gene-Drive Element

The paper tests the evolutionary safety of CRISPR-Cas9 gene drives in yeast by measuring their impact on mutation rates and loss-of-heterozygosity, finding minimal effects.

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

This study shows repeated Omicron exposures reduce immune imprinting from wildtype vaccines, leading to higher neutralizing antibodies against XBB variants.

Tropism of AAV.CPP.16 in the respiratory tract and its application for a CRISPR-based gene therapy against SARS-CoV-2

This study evaluates AAV.CPP.16 as a gene delivery vector for respiratory diseases and demonstrates its use in a CRISPR-based therapy targeting SARS-CoV-2.

Xanthomonas citri subsp. citri type III effector PthA4 directs the dynamical expression of a putative citrus carbohydrate-binding protein gene for canker formation

This study shows PthA4 induces CsLOB1, which in turn regulates Cs9g12620 expression, promoting citrus canker through dynamic gene regulation.

Photosymbiosis reduces the environmental stress response under a heat challenge in a facultatively symbiotic coral

This study shows that photosymbiosis in corals reduces the environmental stress response under heat challenge, contradicting the oxidative bleaching hypothesis.

Elucidating the Synergistic Role of Elm1 and Gin4 Kinases in Regulating Septin Hourglass Assembly

The paper shows Elm1 and Gin4 kinases regulate each other through direct binding and phosphorylation to control septin hourglass assembly and remodeling during different cell cycle stages in yeast.

Bni5 tethers myosin-II to septins to enhance retrograde actin flow and the robustness of cytokinesis

This study identifies Bni5's role in tethering myosin-II to septins in budding yeast, enhancing retrograde actin flow and cytokinesis robustness.

The Arabidopsis Information Resource in 2024

The paper updates the Arabidopsis Information Resource, detailing its curation efforts, infrastructure improvements, and analysis of gene function annotations.

The FXR1 network acts as signaling scaffold for actomyosin remodeling

The paper identifies the FXR1 network as a cytoplasmic mRNA scaffold that facilitates actomyosin remodeling by organizing signaling interactions.

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

This paper develops an injectable platform for ultra-long-term hydrophilic drug delivery, achieving sustained release over six months in vivo.

Lac-Phe mediates the anti-obesity effect of metformin

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2-driven Esophageal Hyperplasia

This study identifies pyrimethamine as an NRF2 inhibitor that suppresses esophageal hyperplasia in a mouse model and shows potential for clinical use in NRF2-high ESCC.

FASlpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

This study shows that FASlpr gene dosage affects lymphoproliferation and T cell differentiation in lupus models, with heterozygous Faslpr leading to increased autoantibodies and Th1 cell skewing.

Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

This study identifies and evaluates LFS-1107, a CRM1 inhibitor that suppresses ENKTL cell growth by blocking NF-κB signaling and shows promise for clinical translation.

Identification of CD44 as a key mediator of cell traction force generation in hyaluronic acid-rich extracellular matrices

This study identifies CD44 as a key mediator of cell traction force generation in hyaluronic acid-rich extracellular matrices, showing its role in modulating collagen network mechanics and tumor invasion.

A bioactive peptide from the pearl has dual roles in resisting SARS-CoV-2 infection and its complications

This study identifies a bioactive peptide from a pearl oyster that inhibits SARS-CoV-2 infection and enhances ACE2 activity to treat related complications.

Monocytes reprogrammed by 4-PBA potently contribute to the resolution of inflammation and atherosclerosis

This study shows that 4-PBA reprograms monocytes to resolve inflammation and atherosclerosis by altering adhesion and increasing anti-inflammatory markers.

Long-Term In Vivo Molecular Monitoring Using Aptamer-Graphene Microtransistors

This paper introduces AGMs for long-term in vivo molecular monitoring, demonstrating detection of dopamine and serotonin in blood and in vivo dopamine release in mice for over a week.

Di- and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair

This study identifies distinct roles of H3K36 dimethylation and trimethylation in DNA double-strand break repair via NHEJ and HR in yeast and humans.

Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variants

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.

Efficacy of the first bioactive peptide from the pearl

The paper identifies a novel ACE-inhibitory peptide from pearl matrix and demonstrates its potential as an antihypertensive agent.

Epigenetic insights into GABAergic development in Dravet Syndrome iPSC and therapeutic implications

This study investigates epigenetic changes in GABAergic development using DS iPSCs and shows that VPA can rescue some chromatin abnormalities.

Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Diseases

This study identifies shared and distinct mechanisms of UBA1 inactivation in VEXAS syndrome and related diseases, revealing how different mutations affect ubiquitin transfer to E2 enzymes.

Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation

This paper introduces Spiral NeuroString, high-density soft bioelectronic fibers for multimodal sensing and stimulation, demonstrating their use in GI motility mapping, serotonin sensing, and brain recordings.