X. Wei

New insights into the earlier evolutionary history of epiphytic macrolichens

The paper identifies a Jurassic fossil as an epiphytic macrolichen, suggesting macrolichen diversity predates the Cenozoic diversification of extant lineages.

Viromes in Marine Ecosystems Reveal Remarkable Invertebrate RNA Virus Diversity

This study identifies 315 new RNA viruses in marine invertebrates, revealing hidden diversity and potential host switching events in ocean viromes.

High-speed widefield handheld swept-source OCT angiography with a VCSEL light source

This paper presents a high-speed handheld OCT/OCTA system for retinal imaging in clinical settings, demonstrating its use in neonatal and surgical patients.

Loss of PABPC1 is compensated by elevated PABPC4 and correlates with transcriptome changes

The paper shows that loss of PABPC1 increases PABPC4 levels and alters key transcriptional regulators in HEK293 cells.

Paip2 associates with PABPC1 on mRNA, and may facilitate PABPC1 dissociation from mRNA upon deadenylation

This study identifies Paip2 as a protein that interacts with PABPC1 on mRNA and may help PABPC1 detach from mRNA during deadenylation.

Poly(A) binding protein is required for mRNP remodeling to form P-bodies in mammalian cells

The paper shows PABPC1 is essential for P-body formation despite not being present in P-bodies, and demonstrates GW182's role in mediating this process.

Molecular mechanism of N-terminal acetylation by the ternary NatC complex

The paper reports the Cryo-EM structure of S. pombe NatC complex and identifies IP6 as a stabilizer, revealing substrate specificity overlaps with NatE.

scRNA-seq-based analysis of skeletal muscle response to denervation reveals selective activation of muscle-resident glial cells and fibroblasts

This study uses scRNA-seq to analyze skeletal muscle response to denervation, finding selective activation of muscle-resident glial cells and fibroblasts, and their role in NMJ repair and fibrosis.

Multiple infiltration and cross-species transmission of foamy viruses across Paleozoic to Cenozoic era

This study identifies 412 foamy viruses from 6 lineages in amphibians, revealing co-evolutionary patterns and cross-species transmission across Paleozoic to Cenozoic eras.

Exosomal miR-224 contributes to hemolymph microbiota homeostasis during bacterial infection in crustacean

This study identifies exosomal miR-224's role in maintaining hemolymph microbiota homeostasis during bacterial infection in mud crabs by modulating immune signaling pathways.

Keratin-Based Epidermal Green Autofluorescence is a Common Biomarker of Organ Injury

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

Structural insight into outer membrane asymmetry maintenance of Gram-negative bacteria by the phospholipid transporter MlaFEDB

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

Transcriptome analysis reveals the main metabolic pathway of c-GMP induced by salt stress in tomato seedlings

This study identifies the metabolic pathways regulated by c-GMP in tomato seedlings under salt stress, showing its role in enhancing salt tolerance through changes in gene expression and metabolic profiles.

Changes in biochemistry and histochemical characteristics during somatic embryogenesis in Ormosia henryi Prain

This study examines how energy substances, reactive oxygen species, enzyme activities, and endogenous hormones influence somatic embryogenesis and abnormal callus formation in Ormosia henryi Prain.

Two-target quantitative PCR to predict library composition for shallow shotgun sequencing

The paper develops a two-target qPCR assay to predict human-to-microbe ratios in samples, enabling better planning of shotgun sequencing experiments.

Therapeutic inhibition of keratinocyte TRPV3 sensory channels by local anesthetic dyclonine

This study shows that dyclonine inhibits TRPV3 channels in keratinocytes, rescuing cell death and reducing pruritus in a mouse model.

Small molecules inhibit SARS-COV-2 induced aberrant inflammation and viral replication in mice by targeting S100A8/A9-TLR4 axis

Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B

This study analyzes 8,839 C. difficile genomes to reveal recombination-driven evolution of toxins A and B, develops a subtyping method, and creates a database for therapeutic and research use.

Efficient and stable metabarcoding sequencing from DNBSEQ-G400 sequencer examined by large fungal community analysis

This study compares the DNBSEQ-G400 and Illumina MiSeq platforms for metabarcoding fungal communities, finding DNBSEQ-G400 to be more accurate, less biased, and cost-effective.

The effect of delayed processing on ovarian tissue stored for fertility preservation

This study examines the effect of delayed processing on ovarian tissue for fertility preservation, finding that a 48-hour delay before cryopreservation does not negatively impact primordial follicle health.

SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes

This study identifies SF3B1 mutations causing anemia in MDS by inducing missplicing of MAP3K7, leading to reduced p38 MAPK activity and disrupted erythroid differentiation.

Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells

The paper identifies PRMT5 as a synthetic lethal target with gemcitabine in pancreatic cancer using CRISPR screening in a PDX model.

Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic

The paper identifies and characterizes ORF3d, a novel overlapping gene in SARS-CoV-2, showing its presence in pangolin-CoVs and its evolutionary significance.

Multiple expression assessments of ACE2 and TMPRSS2 SARS-CoV-2 entry molecules in the urinary tract and their associations with clinical manifestations of COVID-19

A hybrid open-top light-sheet microscope for multi-scale imaging of cleared tissues

The paper introduces a hybrid light-sheet microscope that enables versatile multi-scale imaging of cleared tissues with varying resolution, geometry, and compatibility requirements.

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

Evidence of the Recombinant Origin and Ongoing Mutations in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

This study identifies SARS-CoV-2 as a recombinant virus of bat and pangolin coronaviruses and reports ongoing mutations in its genome.

OLGenie: Estimating Natural Selection to Predict Functional Overlapping Genes

OLGenie estimates natural selection in overlapping genes to identify functionally constrained gene pairs with high accuracy.

Identification and evolution of avian endogenous foamy viruses

The paper identifies endogenous foamy viruses in two stork species, showing independent integration events in birds and expanding the known taxonomic distribution of foamy viruses.

Deviations from Hardy Weinberg Equilibrium at CCR5-Δ32 in Large Sequencing Data Sets?

The paper examines deviations from Hardy-Weinberg Equilibrium at CCR5-Δ32 in UKB WES and gnomAD data, finding a deficiency of homozygotes and supporting a deleterious effect of the deletion mutation.