Y. Jiang

Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathway

This study shows estrogen prevents age-related failure in beige adipogenesis by controlling ER stress via NAMPT, improving energy expenditure and glucose tolerance in mice.

The super-pangenome of Populus unveil genomic facets for adaptation and diversification in widespread forest trees

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

Metabolic influence of core ciliates within the rumen microbiome

The paper investigates the metabolic roles of core ciliates in the rumen microbiome, finding that they contribute significantly to volatile fatty acid production and hydrogen metabolism, particularly in high methane-emitting animals.

Combinatorial selective ER-phagy remodels the ER during neurogenesis

The paper quantifies ER proteome remodeling during neurogenesis using ER-phagy receptors and identifies receptor-specific ER protein clearance mechanisms.

Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity

This study rationally engineers ZIP8 to alter its substrate specificity, identifying a conditional selectivity filter that determines substrate preference based on transporter conformation.

AutoUnmix: an autoencoder-based spectral unmixing method for multi-color fluorescence microscopy imaging

AutoUnmix is a deep learning-based spectral unmixing method for multi-color fluorescence microscopy that outperforms existing methods in speed and accuracy.

Rapid intracellular acidification is a novel plant defense response countered by the brown planthopper

The paper identifies NlCA, a salivary carbonic anhydrase from the brown planthopper, as a key factor in modulating rice cell pH to suppress defense responses and facilitate insect survival.

Key role of down-regulated in adenoma (SLC26A3) chloride/bicarbonate exchanger in linaclotide-stimulated intestinal bicarbonate secretion upon loss of CFTR function

This study shows linaclotide stimulates bicarbonate secretion in CFTR-deficient tissues by enhancing DRA expression, suggesting DRA as a therapeutic target for CF-related intestinal dysfunction.

Post-translational modification of SPATULA by SECRET AGENT and SPINDLY promotes organ symmetry transition at the gynoecium apex

The paper shows that SPINDLY and SECRET AGENT modify SPATULA with O-fucose and O-GlcNAc to promote a symmetry transition in the gynoecium.

A genetic mosaic mouse model illuminates the pre-malignant progression of basal-like breast cancer

This paper develops a mouse model to study the pre-malignant progression of basal-like breast cancer, revealing stepwise lesion development and spatially resolved mutant cell analysis.

S2' cleavage site plays a decisive role in expansion of Vero cell tropism by infectious bronchitis virus HV80, with Q855H promoting cell-to-cell fusion

This study identifies the S2' cleavage site and Q855H mutation as critical for HV80's Vero cell tropism and cell-to-cell fusion.

Radiation-induced persistent DNA damage response and late toxicity in cardiac tissue

This study investigates early and late cardiac toxicity in irradiated A/J mice, identifying persistent DNA damage and macrophage polarization as potential contributors to long-term cardiac complications.

Complete Workflow for High Throughput Human Single Skeletal Muscle Fiber Proteomics

This paper introduces a high-throughput single skeletal muscle fiber proteomics method, achieving faster analysis with sufficient proteome depth compared to existing methods.

Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis

This study identifies CRB3's role in navigating Rab11 vesicles to promote γTuRC assembly during ciliogenesis and its regulation of Hh and Wnt signaling in tumorigenesis.

Homocysteine accelerates hepatocyte autophagy by upregulation of TFEB via DNMT3b-mediated DNA hypomethylation

This study shows homocysteine increases hepatocyte autophagy by upregulating TFEB through DNMT3b-mediated DNA hypomethylation of the TFEB promoter.

Illumination of the complement receptors C3aR and C5aR signaling by anaphylatoxins

This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.

Redistribution and activation of CD16brightCD56dim NK cell subset to fight against Omicron subvariant BA.2 after COVID-19 vaccination

This study shows that COVID-19 vaccination enhances the activation and redistribution of CD16brightCD56dim NK cells in Omicron BA.2-infected patients, improving clinical outcomes.

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

This study identifies C5aR1 as a targetable receptor on cancer cells that enhances radiotherapy efficacy in immunosuppressive tumours by promoting apoptosis without affecting normal tissues.

Single-cell transcriptional analysis of lamina propria lymphocytes in the jejunum reveals ILC-like cells in pigs

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

Directed Biosynthesis of Mitragynine Stereoisomers

This study identifies the biosynthetic pathway for mitragynine and related alkaloids and uses it to enzymatically produce mitragynine, its epimer, and fluorinated analogues.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

Antifungal tolerance and resistance emerge at distinct drug concentrations and rely upon different aneuploid chromosomes

This study identifies that antifungal drug tolerance and resistance in Candida albicans emerge at different drug concentrations and are associated with distinct aneuploid chromosomes.

Unraveling the viral dark matter of the rumen microbiome with a new global virome database

The paper creates a rumen virome database (RVD) and identifies 397,180 viral species-level OTUs, improving classification rates and revealing ecosystem impacts of rumen viruses.

Prototype matching: children's preference for forming scientific concepts

This study investigates children's preference for using prototypes over analytical methods in scientific concept learning, finding a strong preference for prototype matching.

Soft and stretchable organic bioelectronics for continuous intra-operative neurophysiological monitoring during microsurgery

This paper introduces a soft, stretchable organic bioelectronic system for continuous intra-operative neurophysiological monitoring during microsurgery, demonstrating improved signal quality and reduced post-operative complications in animal models.

Comparative genomic analysis between Leonurus japonicus and Leonurus sibiricus

This study reports chromosome-level genome sequences of two Leonurus species, providing resources for studying bioactive molecules in medicinal plants.

Exploring the genome and protein space of viruses

The paper estimates the genetic diversity of viruses using simulated discovery processes, finding that less than 3% of viral genetic diversity has been uncovered.

PARK15/FBXO7 is dispensable for PINK1/Parkin-dependent mitophagy in iNeuron and HeLa cell systems

This study shows FBXO7 is not required for PINK1/Parkin-dependent mitophagy in HeLa and iNeuron cells, as its absence does not impair key mitophagy processes.

Structure of a G protein-coupled receptor with GRK2 and a biased ligand

The paper reports the structure of NTSR1 bound to GRK2, Gq, and a biased ligand, revealing how the ligand enhances GRK2 binding and enables arrestin-biased signaling.