Neuroscience and Neuropharmacology Research

Restoring hippocampal sharp-wave ripples under glutamate transporter dysfunction

This study investigates whether KCNQ-channel openers can restore hippocampal sharp-wave ripples disrupted by glutamate transporter dysfunction in mouse models.

Disease-associated mutations in GluK2 disrupt compartment-specific regulatory mechanisms controlling kainate receptor membrane trafficking.

This study shows how two disease-associated GluK2 mutations disrupt different aspects of receptor trafficking and signaling in neurons.

Accurate computation of ionic concentrations in the synaptic cleftrequires the full Poisson-Nernst-Planck (PNP) equations

The paper shows that neglecting electrical forces in synaptic cleft models leads to significant errors in ionic concentration predictions, demonstrating the necessity of using the full PNP equations.

Cell-type-specific synaptic scaling mechanisms differentially contribute to associative learning

The paper shows that excitatory and inhibitory synaptic scaling mechanisms interact to shape memory specificity during associative learning.

Effects of Glutamate Delta 1 Receptor (GluD1) Deletion on the Ultrastructural Features of Corticostriatal and Thalamostriatal Synapses in Mice

This study investigates the effects of GluD1 deletion on synapse ultrastructure in mice, finding no significant changes in synaptic morphology despite functional deficits.

An unsuspected physiological role for mGluRIII glutamate receptors in hippocampal area CA1

This study reveals a previously unrecognized role of mGluRIII receptors in modulating GABA release onto pyramidal cells in hippocampal CA1 under physiological conditions.

Tracking long-term natural changes in hippocampal excitatory to inhibitory synapses from spikes

The paper tracks long-term changes in hippocampal excitatory-to-inhibitory synapses using spike data from mice, finding that covariance of pre- and postsynaptic activity improves prediction of synaptic efficacy fluctuations.

An atomic interaction conserved for over 600 million years gates inhibitory neurotransmission

The paper identifies a conserved atomic interaction in inhibitory neurotransmitter receptors that stabilizes channel gating and explains disease-linked mutations.

Thyroid hormones maintain parvalbumin neuron functions in the mouse neocortex

This study shows that thyroid hormones are essential for maintaining the function of mature parvalbumin neurons in the mouse neocortex, affecting behavior, sleep, and neural oscillations.

Open-State Dynamics and Allosteric Modulation of the α1β3γ2 GABAA Receptor Stabilized by L9'T/S Substitutions

This study stabilizes an open-state conformation of the α1β3γ2 GABAAR using mutations and simulations, revealing how allosteric modulators and antagonists affect receptor gating.

Disruption of glutamine carrier Slc38a1 causes cognitive impairment, anxiety and depressive-like behavior

This study shows that disrupting Slc38a1 in mice leads to cognitive impairments, anxiety, and depressive-like behaviors, linking GABAergic dysfunction to these conditions.

Temporal cortex astrocytic Gi-GPCR signaling regulates learned threat responses

The paper shows that Gi-GPCR signaling in temporal cortex astrocytes enhances fear memory retrieval by modulating Ca2+ transients in response to sensory cues.

Specialized outputs and behavioral contributions of Purkinje cell subtypes

The paper identifies molecularly distinct Purkinje cell subtypes and shows they regulate specific behaviors through targeted silencing experiments.

Homeostatic regulation of intrinsic neuronal excitability in visual thalamic relay cells induced by brief monocular deprivation

This study shows that brief monocular deprivation induces homeostatic changes in intrinsic neuronal excitability in thalamic relay cells, involving Kv1 and Nav1 channel regulation and electrical coupling.

Presynaptic temporal dynamics flexibly set input weights in the mouse escape circuit

The paper shows that presynaptic temporal dynamics determine input weights in mouse escape circuit neurons, enabling flexible decision-making during threat.

A unified law for inhibitory control in active dendrites

The paper develops an analytical framework to understand how inhibition affects neuronal computation across dendritic compartments, revealing a unified law that explains inhibitory leverage in active dendrites.

Astrocytes transform the transcriptomic and epigenetic landscape of developing cortical neurons to promote activity via intrinsic excitability control

This study shows astrocytes alter the transcriptomic and epigenetic landscape of developing cortical neurons, promoting intrinsic excitability and influencing disease-related pathways.

Primate Hippocampus Reveals Distinct Rules for Associative Synaptic Plasticity

The paper examines synaptic plasticity in nonhuman primates, finding that theta-burst stimulation induces LTP with a lower threshold for synaptic tagging and capture compared to rodents.

Chronic postnatal chemogenetic activation of forebrain excitatory neurons modulates adult glial function and metabolism in male mice

This study shows that postnatal chemogenetic activation of forebrain excitatory neurons leads to anxiety-like behaviors and altered glial function and metabolism in adult mice.

Dendrite-soma interactions in cultured hippocampal neurons form non-random structural motifs with local presynaptic enrichment and strengthening

The paper identifies non-random structural motifs in dendrite-soma interactions in cultured hippocampal neurons and shows their association with presynaptic enrichment and strengthening.

GluDs are ionotropic dopamine receptors tuned by G-proteins

The paper identifies dopamine as a direct agonist of GluDs, showing G-protein regulation of their activity and implications for neurological diseases.

Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility

The paper shows that plasticity at long-range GABAergic synapses from prefrontal PV neurons regulates cognitive flexibility through optogenetic and electrophysiological experiments.

Impact of impaired endogenous neurosteroidogenesis on outcomes following chronic alcohol exposure.

This study shows that chronic alcohol exposure impairs neurosteroid production and that enhancing neurosteroid levels can affect alcohol consumption and withdrawal behaviors.

Presynaptic GABAA Receptors Mediate Ethanol-Induced Suppression at a Central Auditory Synapse

The paper identifies ethanol-enhanced presynaptic shunting inhibition at the first central auditory synapse as a mechanism for alcohol-induced auditory dysfunction.

Physical contact reveals a hidden layer of cortical architecture

The paper maps physical cell-cell contacts in mouse visual cortex, revealing a dense contactome that exceeds synaptic connectivity and highlights the role of astrocytes in shaping the neural microenvironment.

Histamine originating from the BNST modulates corticostriatal synaptic transmission during early postnatal development

This study identifies the oval nucleus of the bed nucleus of stria terminalis (ovBNST) as a source of histamine that modulates corticostriatal synaptic transmission during early postnatal development.

UP-REGULATION OF SYNAPTOBREVIN-2 TO DELAY AGE-RELATED COGNITIVE IMPAIRMENT

This study shows that overexpressing synaptobrevin-2 in mice delays age-related cognitive decline by improving synaptic function and memory.

Distinct Roles of CaMKII in Synaptic Vesicle Dynamics at Zebrafish Retinal Rod Bipolar Ribbon Synapses

This study manipulates CaMKII activity in zebrafish retinal rod bipolar cell ribbon synapses to show that both inhibition and elevation impair neurotransmitter release, suggesting optimal CaMKII levels are required for normal function.

Tuft dendrites in frontal motor cortex enable flexible learning

The paper investigates the role of apical tuft dendrites in the anterolateral motor cortex in flexible learning using a rule-switching paradigm.

Magnetogenetic control of endogenous calcium signaling via ROS-sensitive ion channels reveals astrocytic regulation of neural circuit activity

This paper demonstrates that magnetic control of astrocytic calcium signaling can modulate neural circuit activity, introducing a tool for wireless, cell-specific calcium regulation.