Neuroscience and Neuropharmacology Research

Structured Sampling of Molecularly Classified Mossy Fiber Inputs by Cerebellar Granule Cells

The paper examines how cerebellar granule cells sample distinct mossy fiber inputs using vCLEM data from a mouse cerebellum, revealing structured, non-random sampling patterns.

Optogenetic Isolation of the Amacrine Cell-OFF Bipolar Cell Synapse Shows Selective D1R Control of Glycinergic Transmission

The paper uses optogenetics to isolate the amacrine cell-OFF bipolar cell synapse and shows that D1R selectively reduces glycinergic inhibition.

Competitive Olivocerebellar Input Selection Promotes Resilient Circuit Formation

The paper shows that competitive input selection in the olivocerebellar circuit promotes resilient circuit formation, preserving motor and social behaviors despite compromised inputs.

A computational framework with voltage-dependent synaptic function explains LTP-dominant plasticity during functional electrical stimulation therapy

The paper develops a computational framework to explain how FES therapy induces LTP-dominant plasticity through voltage-dependent synaptic rules and spike interactions.

Spatiotemporal proteomics elucidates trafficking and localization of Neuroligins to the axon initial segment plasma membrane

The paper uses spatiotemporal proteomics to study the trafficking and localization of NLGN1 and NLGN2 to the axon initial segment, revealing distinct sorting mechanisms and functional roles.

Rotating a petavoxel reconstruction exposes the viewing-angle bias inherent to Golgi-Cox and confocal dendritic-spine classification

The paper shows that dendritic spine shape classification varies with viewing angle, challenging traditional 2D methods like Golgi-Cox and confocal microscopy.

Terminal Schwann Cells Regulate Presynaptic Vesicle Homeostasis but Not Neuromuscular Junction Integrity in Mice

This study identifies Col20a1 as a marker for terminal Schwann cells and shows they regulate presynaptic vesicle homeostasis but not neuromuscular junction integrity in mice.

A glial source of noradrenaline shapes synaptic integration and motor adaptation

The paper identifies Bergmann glia as a source of noradrenaline that modulates synaptic integration and motor adaptation in the cerebellum.

Ratiometric iGluSnFr imaging to assess tonic glutamate in the cerebral cortex

This paper uses ratiometric iGluSnFr imaging to measure ambient glutamate levels in brain slices, showing regional differences and transporter sensitivity.

Gq-pathway activation in hippocampal CA1 astrocytes rescues ischemia-induced memory deficits and synaptic plasticity

This study shows that activating the Gq pathway in hippocampal astrocytes improves memory and synaptic plasticity after stroke in mice.

Efficient Transmission in the Blowfly Early Visual Synapses Through the Regularization of Vesicle Release

The paper challenges the Poissonian model of vesicle release in blowfly synapses, showing that regularization of release reduces noise and supports efficient transmission.

Structural basis for activation and potentiation in a human α5β3 GABAA receptor

This paper reports cryo-EM structures of human α5β3 GABAARs with modulators, revealing activation mechanisms and differential responses to GABA and etomidate.

Synergistic effects of presynaptic and postsynaptic neurons give rise to three-stage short-term plasticity in vivo

The paper studies short-term plasticity (STP) in the retinocollicular pathway of mice, revealing three distinct stages of STP involving both synaptic and nonsynaptic mechanisms.

Anatomical organization and origins of VGLUT3-positive axon terminals in the lateral septum.

This study maps the anatomical organization and origins of VGLUT3-positive axon terminals in the lateral septum, identifying multiple sources beyond the raphe nuclei.

Dorsomedial Striatum Calcium Permeable AMPA Receptors in the Development of Aversion-Resistant Alcohol Drinking

The paper investigates how calcium permeable AMPA receptors in the dorsomedial striatum influence aversion-resistant alcohol drinking through changes in receptor subunit composition and function.

Activity-Dependent Postsynaptic Mitochondrial ROS Signaling Drives Avoidance Plasticity in C. elegans

This paper shows that activity-dependent mitochondrial ROS signaling in C. elegans drives avoidance plasticity by enhancing synaptic strength and circuit function.

Opportunistic neuronal fuelling

This study shows neurons switch fuel sources from glucose to lactate when extracellular lactate increases, regardless of activity, revealing lactate availability as the key factor.

A Neuronal Gene Expression Program Underlying Sustained Network Activity

The paper identifies a gene expression program in active neurons that supports sustained network activity, distinct from immediate early gene responses and enriched for excitability regulators.

Functional Continuum of GABAergic Synaptic Dynamics Reflects Genetic Identities

The paper shows that GABAergic synaptic dynamics form a functional continuum aligned with genetic identities, spanning Pvalb to VIP neurons with Sst as an intermediate class.

Depletion of neurocan in the prefrontal cortex impairs temporal order recognition, cognitive flexibility and perisomatic GABAergic innervation

This study shows that reducing neurocan in the prefrontal cortex impairs cognitive flexibility and perisomatic GABAergic innervation in mice.

Robust learning-driven structural and functional plasticity of spines in the mature mouse cortex

This study shows that learning increases spine complexity and formation in adult mice, while reducing spine size, and that spine response discriminability predicts learning performance.

Developmental and age-related synapse elimination is mediated by glial Croquemort

This study identifies glial Croquemort as a key regulator of synapse elimination during development and aging in Drosophila.

Synaptic Plasticity as a Function of the Temporal Derivative

The paper tests if synaptic plasticity depends on the temporal derivative of neural activity, finding LTP for positive derivatives and LTD for negative ones, with no change in stable conditions.

Spontaneous neurotransmitter release is regulated by Unc-5

This study shows that spontaneous neurotransmitter release is regulated by the synaptic function of Unc-5 in Drosophila, affecting synaptic structure and behavior.

Dorsal striatal circuit mechanisms contributing to astrocyte modulation of alcohol-related behaviors

This study investigates how DLS astrocytes contribute to EtOH-induced stimulation and drinking behavior through calcium signaling and cholinergic interactions in mice.

Benzothiazole Derivatives as Dual Modulators of PGE2 and GABAergic Signaling in Skeletal Muscle

This study identifies benzothiazole derivatives that modulate PGE2 and GABAergic signaling in skeletal muscle cells, with one compound downregulating Gabrg2, suggesting links between muscle signaling and neuropsychiatric disorders.

Presynaptic vesicles supply membrane for axonal bouton enlargement during LTP

The paper investigates how presynaptic vesicle density changes during LTP and links it to axonal bouton enlargement.

Ethanol drinking involves astrocytes in male Wistar rats

This study shows chronic ethanol drinking increases GFAP in specific brain regions, and inhibiting astrocytes reduces ethanol consumption without affecting water intake or activity.

Ischemia-Induced Post-Translational Modifications of GLT-1 Mediate Aberrant Trafficking and Impaired Glutamate Uptake

This study shows that ischemia-induced ubiquitination of GLT-1 leads to its internalization and reduced glutamate uptake, contributing to neuronal damage, and that disrupting this process can restore function and provide neuroprotection.

A physiological Na+ signal activates mitochondrial PINK1 to couple synaptic depression to caspase-3-dependent spine pruning

This study identifies a Na+-PINK1 signaling pathway that links NMDA receptor activity to mitochondrial fission and caspase-3-dependent synapse elimination during long-term depression.