Neuroscience and Neuropharmacology Research

DARPP-32 in motor cortex regulates structural and synaptic plasticity in corticothalamic neurons and enables motor learning.

This study shows that DARPP-32 in motor cortex is essential for synaptic plasticity and motor learning by regulating dendritic spines and long-term potentiation in corticothalamic neurons.

Simultaneous in vivo imaging of Ca2+ signals in periarteriolar cholinergic axonal varicosities and arteriole diameter changes in the mouse cerebral cortex

This study uses in vivo two-photon imaging to show that cholinergic axonal Ca2+ signals correlate with arteriolar dilation in mice.

Modeling Synaptic Maturation from Growth Cone to Synapse in Human Organoids

This study develops a centrifugation protocol to isolate growth cones and immature synapses from human organoids, capturing synaptic development stages and enabling models for studying synaptic function and dysfunction.

Local translational repression and retention of SynGAP1 during synaptic plasticity

The paper investigates SynGAP1's local translation during synaptic plasticity, finding that its synthesis is transiently suppressed during LTP induction, opposing the current model of SynGAP1 dispersion.

The CaMKII D135N mutation blocks kinase activity and reduces GluN2B binding

The paper shows the CaMKII D135N mutation blocks kinase activity and reduces GluN2B binding, supporting structural rather than enzymatic function in LTP.

Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis.

This study identifies Nedd4l-mediated ubiquitination of NL2 as essential for astrocyte morphogenesis during development.

Adolescent Astrocyte Dysregulation Impairs Prefrontal Interneuron Maturation and Adult Cognition

This study shows that abnormal astrocyte activity during adolescent prefrontal cortex development leads to synaptic loss, interneuron dysfunction, and cognitive deficits.

CRISPR inhibition of activity-dependent Arc expression in the adult mouse brain has limited effects on plasticity in visual cortex and nucleus accumbens

Developmental Trajectory of Synaptic Remodeling in the Mouse Prefrontal Cortex

The paper characterizes synaptic dynamics during normal mouse prefrontal cortex maturation using combined imaging and quantification methods.

Vesicular acidification modulates the synaptic current: a hybrid diffusion reaction model analysis

The paper develops a diffusion-reaction model to analyze how vesicular acidification modulates AMPA receptor function and synaptic current.

Distinct effects of nonselective Rho-kinase inhibitor fasudil and selective Rho-kinase 2 inhibitor KD025 on serotonin and dopamine release in the nucleus accumbens of mice

This study compares the effects of fasudil and KD025 on serotonin and dopamine release in the nucleus accumbens of mice, finding distinct roles for Rho-kinase 1 and 2 in neurotransmitter regulation.

The human GABAA receptor α4 subunit variant Ile114Asn linked to epilepsy impairs membrane expression with β3 and δ subunits

The paper investigates the effect of the GABAA receptor α4 subunit variant Ile114Asn on membrane expression when combined with β3 and δ subunits, finding reduced maximal GABA-elicited currents.

Synaptic dynamics are a tunable substrate sculpting neuralpopulation activity

The paper shows that synaptic dynamics shape sparse neural activity patterns in granule cells, tuning them to match learning demands.

Spatially-local inhibition and synaptic plasticity together enable dynamic, context-dependent integration of parallel sensory pathways

The paper identifies two circuit mechanisms that explain the spatial selectivity of mouse Off Transient alpha retinal ganglion cells through localized inhibition and synaptic depression.

Layer-5 Pyramidal Cell tLTD Requires Astrocytic Ca2+ and CB1 Receptor Signaling

This study shows that astrocytic Ca2+ signaling and CB1 receptors are required for tLTD at layer-5 pyramidal cell synapses in visual cortex.

Cerebellum violates Marr-Albus predictions to train synapses on long-term anticipatory goals

The paper shows that cerebellar plasticity in mice is driven by anticipatory PF signals preceding CF bursts, contradicting Marr-Albus predictions of coincidence detection.

APOE is a presynaptic protein that accumulates with age and modulates neurotransmitter release

This study identifies APOE as a presynaptic protein enriched in aged female mice, showing it modulates neurotransmitter release and affects synaptic function.

Dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons

This study shows dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons through specific interneuron subtypes and voltage-gated calcium channels.

A Nonsteroidal Reversal Agent Inhibits Allopregnanolone Modulation of α1β3δ GABAA Receptors

The paper identifies DKD99, a nonsteroidal agent that reverses allopregnanolone's modulation of α1β3δ GABAA receptors without affecting GABA's action.

A developmental switch to facilitation shapes synaptic plasticity at neuron-OPC synapses in white matter

The paper shows that neuron-OPC synapses in white matter undergo a developmental switch from synaptic depression to facilitation, enhancing temporal precision of neurotransmission.

Cryo-EM Structures of Higher Order Gephyrin OligomersReveal Principles of Inhibitory Postsynaptic Scaffold Organization

This study determines the structure of higher-order gephyrin oligomers using cryo-EM, revealing how its flexible linker regulates receptor binding and oligomerization.

Differentiated SH-SY5Y Cells Exhibit Neuronal Features but Lack Synaptic Maturity

The paper evaluates the synaptic maturity of SH-SY5Y cells after differentiation and finds they lack functional synapses despite some presynaptic features.

Molecular dissection of protein complexes isolated from sections of human brain

The paper develops a method to study endogenous protein complexes in brain tissue and finds mGluR2/3 heterodimers are abundant in specific human brain regions and associated with depression.

Essential role for plasma membrane glutamate transporters in stimulus intensity coding in auditory neurons

The paper shows that in the auditory system, EAATs rapidly remove glutamate to enable stimulus intensity coding in T-stellate cells, unlike their typical role in maintaining background glutamate levels.

Hippocampal neuronal and astrocytic responses to noradrenaline and natural arousal

This study compares natural arousal and direct locus coeruleus activation in mouse hippocampal CA1, revealing distinct cellular response patterns in astrocytes and neurons.

Subunit selective modulation of GABAA receptors using pharmacogenetically tethered neurosteroids

The paper develops a DART platform to selectively modulate GABAA receptor subunits using neurosteroids, identifying C11-linked compounds that enhance GABA currents in 4/{delta}-containing receptors.

A Non-Classical Neuroactive Steroid Exhibiting Potent, Efficacious GABA A Receptor Agonism and NMDA Receptor Inhibition

This paper characterizes YX84, a novel neuroactive steroid with dual GABA A receptor agonism and NMDA receptor inhibition, showing favorable behavioral tolerability.

PI(4,5)P2-dependence of GABAA receptor channel function revealed by optogenetic manipulation of a binding site

This study reveals that PI(4,5)P2 binding to GABAARs at K311 is functionally significant, as shown through optogenetic manipulation and electrophysiology.

Human-specific multicopy gene FRMPD2 promotes synapse formation via recruitment of neuroligin 1

This study identifies FRMPD2 as a human-specific gene that promotes synapse formation by recruiting neuroligin-1 and interacting with the F-actin network, with implications for brain development and cognitive function.

Insulin Growth Factor 1 affects glutamate receptor activity differently in primary cultures of neocortical versus hippocampal neurons

This study shows IGF-1 enhances glutamate responses in hippocampal neurons but inhibits them in neocortical neurons via AMPA receptor suppression, suggesting neuroprotective roles in the neocortex.