Cardiac electrophysiology and arrhythmias

Atomic-Level Investigation of KCNJ2 Mutations Associated with Ventricular Arrhythmic Syndrome Phenotypes

This study investigates KCNJ2 mutations linked to ventricular arrhythmia using computational modeling and functional analysis, revealing mutation-specific structural perturbations and their impact on channel stability.

Field potential Imaging in human iPSC- derived Cardiomyocytes using UHD-CMOS-MEA

This study uses UHD-CMOS-MEA field potential imaging to detect cardiotoxicity in human iPSC-derived cardiomyocytes by analyzing electrophysiological endpoints and drug effects.

Advanced Cardiovascular Toxicity Screening: Integrating Human iPSC-Derived Cardiomyocytes with In Silico Models

This study integrates hiPSC-derived cardiomyocytes with in silico models to assess drug-induced cardiac risks, demonstrating the platform's ability to predict clinical side effects.

T-World: A highly general computational model of a human ventricular myocyte

T-World is a computational model of human ventricular myocytes that accurately replicates physiological processes and identifies arrhythmia risks, with applications in drug response prediction.

Structural Evaluation of RYR2-CPVT Missense Variants and Continuous Bayesian Estimates of their Penetrance

The paper evaluates RYR2-CPVT missense variants using Bayesian penetrance analysis and finds it outperforms existing tools.

Animal-free recombinant nanobody rescues HCN4 channel deficit in sinus node dysfunction

This study identifies a recombinant nanobody that specifically activates HCN4 channels and rescues sinus node dysfunction in a patient with a loss-of-function mutation.

Electrophysiological comparison of left versus right stellate ganglia neurons

This study compares electrophysiological properties of left and right stellate ganglia neurons in mice, finding differences in resting membrane potential and minimum diastolic potential between sexes and ganglia, but similar action potential characteristics overall.

EFP Analyzer: A fast, accurate, and easy-to-teach program for analyzing Extracellular Field Potentials from iPSC-derived cardiomyocytes

The paper introduces EFP-Analyzer, a software tool for analyzing extracellular field potentials from iPSC-derived cardiomyocytes, showing it accurately measures intervals and detects drug or mutation effects.

Evaluating the predictive accuracy of ion channel models using data from multiple experimental designs

The paper evaluates the predictive accuracy of IKr ion channel models using voltage-clamp data from multiple experimental protocols and identifies parameter heterogeneity across cells.

Control of electromechanical waves in engineered tissue of human iPSC-cardiomyocytes using a Halbach array and magnetic nanoparticles

A Halbach array modulates excitation wave speed in human cardiac cell assemblies with magnetic nanoparticles, increasing conduction velocity by up to 25% when aligned with the wave direction.

Massively parallel reporter assays identify functional enhancer variants at QT interval GWAS loci

The paper identifies functional enhancer variants at QT interval GWAS loci using MPRA and predicts their impact on cardiac gene expression.

Calibration and validation strategy for electromechanical cardiac digital twins

This study calibrates and validates ventricular electromechanical models using ECG and pressure-volume biomarkers to assess their credibility for cardiac Digital Twin applications.

Methadone blockade of IK1 promotes both long QT and Brugada-like arrhythmias: Mechanistic insights from computational modeling

This study uses computational modeling to show that methadone blocks multiple ionic currents, leading to synergistic arrhythmias including long QT and Brugada-like patterns.

Optogenetic quantification of source sink relationship in intact hearts to explain cardiac arrhythmia initiation and protection

This study uses optogenetics to measure cardiac parameters in mouse hearts, revealing that reduced inward rectifying K+ currents and disrupted coupling increase arrhythmia risk.

Sympathetic Stimulation Can Compensate for Hypocalcaemia-Induced Bradycardia in Human and Rabbit Sinoatrial Node Cells

This study extends SANC models with β-AR signaling to show that sympathetic stimulation can compensate for hypocalcaemia-induced bradycardia in human and rabbit cells.

Comparison of in silico predictions of action potential duration in response to inhibition of IKr and ICaL with new human ex vivo recordings

This paper compares in silico predictions of action potential duration changes with new human ex vivo recordings under IKr and ICaL inhibition, finding that no model accurately predicts all experimental outcomes.

Phosphoinositide Depletion and Compensatory β-adrenergic Signaling in Angiotensin II-Induced Heart Disease: Protection Through PTEN Inhibition

This study shows chronic AngII signaling disrupts cardiac phosphoinositide homeostasis, leading to cardiac dysfunction, but PTEN inhibition protects by preserving PI(3,4,5)P3 levels and reducing fibrosis.

The novel SCN5A-P1891A mutation is associated with left ventricular hypertrabeculation and links Nav1.5 to cardiomyocyte proliferation and disrupted 3D cardiac tissue formation

This study identifies a novel SCN5A mutation linked to left ventricular hypertrabeculation and shows its impact on cardiomyocyte proliferation and 3D cardiac tissue formation.

Myocardial cGMP-PKG1alpha dysregulation contributes to VT pathogenesis in type II diabetes and metabolic syndrome.

This study identifies cGMP reduction as a driver of VT in DMII and metabolic syndrome, showing that pharmacological modulation of cGMP-PKG1alpha pathways can reduce VT inducibility.

Validation of a Demography-Based Adaptive QTc Formula using Pediatric and Adult Datasets Acquired from Humans and Guinea Pigs

This study introduces and validates an adaptive QTc formula (QTcAd) that adjusts for age demographics, showing improved performance across human and guinea pig age groups compared to existing formulas.

p.D372H: A novel SCN5A mutation associated with Brugada syndrome

The paper identifies a novel SCN5A mutation, D372H, associated with Brugada syndrome and demonstrates its functional impact on sodium channel activity and expression.

Redefining catecholaminergic polymorphic ventricular tachycardia (CPVT) as a neurocardiac condition

This paper redefines CPVT as a neurocardiac condition by showing RyR2 mutations affect both cardiac and neuronal function, leading to altered calcium homeostasis and increased sympathetic innervation.

14-3-3 promotes sarcolemmal expression of cardiac CaV1.2 and nucleates isoproterenol-triggered channel super-clustering

This study shows 14-3-3 promotes CaV1.2 sarcolemmal expression and nucleates its super-clustering in response to isoproterenol in cardiomyocytes.

Deletion of PIEZO1 in adult cardiomyocytes accelerates cardiac aging and causes premature death

This study shows that deleting PIEZO1 in adult cardiomyocytes leads to accelerated cardiac aging and premature death in mice.

Fibroblast Density is a Risk Factor for Drug-induced Arrhythmias

This study uses mathematical models to show that fibroblast density has a biphasic effect on drug-induced arrhythmias, increasing PVC susceptibility at moderate levels but reducing it at high levels.

Atrioventricular nodal reentrant tachycardia onset,sustainability, and spontaneous termination in rabbit atrioventricular node model with autonomic nervous system control

This study uses a rabbit atrioventricular node model with autonomic nervous system control to simulate AVNRT onset, sustainability, and termination, revealing how ANS modulation affects these processes.

The Brugada syndrome associated gene WT1 impacts on SCN5A expression and cardiac conduction

This study shows WT1 regulates SCN5A expression and cardiac conduction in Brugada syndrome through a regulatory element in the RV.

FGF12A Regulates Nav1.5 via CaM-regulated and CaM-independent Mechanisms

This study investigates how FGF12A regulates Nav1.5 channel gating through CaM-dependent and CaM-independent mechanisms, revealing distinct effects on inactivation and persistent late current.

Real-time prediction of drug-induced proarrhythmic risk with sex-specific cardiac emulators

This paper develops sex-specific cardiac emulators to predict drug-induced QT interval prolongation in real-time, achieving high accuracy and drastically reducing computational time for drug safety assessments.

Differential effects of obesity and diabetes on the action potential waveform and inward currents in rat ventricular myocytes.

This study compares the effects of obesity and diabetes on action potential parameters and ion currents in rat ventricular myocytes, finding distinct impacts of obesity alone versus obesity with diabetes.