Cardiac electrophysiology and arrhythmias

FGF13 regulates cardiomyocyte impulse propagation via Cx43 trafficking independent of voltage-gated sodium channels

This study shows FGF13 regulates Cx43 trafficking and cardiac impulse propagation without involving voltage-gated sodium channels.

Role of Dynamical Instability in QT Interval Variability and Early Afterdepolarization Propensity

This study shows that increased QT interval variability (QTV) can precede early afterdepolarizations (EADs) due to intrinsic dynamical instability in cardiac cells, offering an early warning signal for arrhythmia risk.

Calibrated Functional Data Decreases Clinical Uncertainty for KCNH2-related Long QT Syndrome

The paper presents a method to reduce clinical uncertainty in KCNH2-related long QT syndrome by using calibrated functional data to classify variants of uncertain significance.

Variability in reported midpoints of (in)activationof cardiac INa

This paper reviews and visualizes variability in reported midpoints of activation and inactivation of cardiac INa, finding large between-experiment variation and classifying contributing factors.

In vitro Sex-specific Function-Structure Relationship in Neonatal Rat Cardiac Sheets

This study characterizes sex-specific differences in neonatal rat ventricular myocytes (NRVMs) using an in vitro heart-on-a-chip platform, showing structural and functional divergence driven by sex chromosomes.

Exploring cardiac phenotypes of Drosophila orthologues of human genes associated to Brugada Syndrome (BrS)

The paper uses Drosophila to test if genes near BrS risk loci affect cardiac function, identifying potential candidates for further study.

Reduced gap junction coupling amplifies the effects of cardiomyocyte variability and destabilizes the heartbeat

This study shows that reduced gap junction coupling between cardiomyocytes amplifies cellular variability and leads to arrhythmias by causing nonhomogeneous action potentials and early after-depolarizations.

Atrial Granules in Atrial Cardiomyocytes as Acidic Calcium Stores

This study investigates the distribution and function of atrial granules in guinea pig and goat cardiomyocytes, finding they are acidic calcium stores closely associated with the sarcoplasmic reticulum and increase in number during atrial fibrillation.

Electrodiffusion dynamics in the cardiomyocyte dyad at nano-scale resolution using the Poisson-Nernst-Planck (PNP) equations

The paper presents a nano-scale computational model of the cardiac dyad using the Poisson-Nernst-Planck equations to study electrodiffusion dynamics and their impact on calcium release.

Transient AMPK activation by nutrient stress of high fat diet preserves cardiac electrophysiological stability and protects against arrhythmias

This study shows that AMPK activation by high-fat diet reduces arrhythmia risk by improving cardiac electrophysiology and mitochondrial function.

Paradoxical SERCA dysregulation contributes to atrial fibrillation in a model of diet-induced obesity

This study shows that diet-induced obesity paradoxically increases SERCA activity in atrial myocytes, contributing to atrial fibrillation through altered Ca2+ dynamics.

Disturbed repolarisation-relaxation coupling during acute ischaemia permits systolic mechano-arrhythmogenesis.

This study shows that disturbed repolarisation-relaxation coupling during acute ischaemia increases systolic mechano-arrhythmogenesis, which can be mitigated by restoring coupling or targeting calcium, TRPA1, or ROS.

Independent derivations of the axis of arrhythmia for predicting drug-induced torsades de pointes

This paper derives the axis of arrhythmia independently from drug datasets and biophysical simulations, showing convergence in predicting pro-arrhythmic risk with high accuracy.

A primate model organism for cardiac arrhythmias identifies a magnesium transporter in pacemaker function

The paper identifies a magnesium transporter, SLC41A2, as critical for primate cardiac pacemaker function using a mouse lemur model of arrhythmias.

Identification of candidate causal cis-regulatory variants underlying electrocardiographic QT interval GWAS loci

The paper identifies candidate causal cis-regulatory variants at electrocardiographic QT interval GWAS loci by integrating open chromatin data and expression quantitative trait loci.

Modeling Atrial Fibrillation through Intermittent Tachypacing-Induced Remodeling in hiPSC-Derived Atrial Cardiomyocytes and Atrial Fibroblast

This study uses hiPSC-derived atrial cardiomyocytes and fibroblasts to model atrial fibrillation through intermittent tachypacing, showing increased AP frequency and fibrosis markers.

AI-based identification of cardiac Purkinje fiber cells isolated from whole adult sheep hearts

This paper develops a deep learning-based method to isolate and classify Purkinje fiber cells from adult sheep hearts using imaging data and validation techniques.

Calcium homeostatic feedback control predicts atrial fibrillation initiation, remodeling, and progression

This study develops a computational model of calcium homeostatic feedback to simulate atrial fibrillation progression from healthy to remodeled tissue.

Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy

The paper uses proximity proteomics to study the cardiac dyad in heart failure, identifying Galectin-1 as a positive modulator of cardiac contractility and relaxation.

Cardiac electrical abnormalities in a mouse model of left ventricular non-compaction cardiomyopathy

This study examines how MIB1 mutations in mice affect cardiac electrical activity, finding altered ion currents and prolonged action potential duration linked to arrhythmia risk.

PKC Promotes T-Tubule Membrane Loss by Activating a PKD-NFκB Endocytic Pathway

This study identifies PKC-driven T-tubule membrane loss through a PKD-NFκB endocytic pathway in cardiomyocytes, showing impaired contractility and arrhythmia risk.

Early onset of Ca2+ waves and synchronization in multicellular clusters facilitate focal arrhythmogenesis in human heart failure

This study shows that early Ca2+ waves and synchronization in human heart failure tissue increase arrhythmia risk by promoting focal excitation through altered intercellular connectivity.

Natural genetic variation quantitatively regulates heart-rate and -dimension

The paper maps and validates key genetic loci influencing heart rate and function in fish, identifying potential targets for cardiac disease treatment.

Hypoxia Exacerbates Kir2.1 Channel Dysfunction in an Andersen-Tawil Syndrome Variant Through a SUMO-Dependent Mechanism

This study shows hypoxia worsens Kir2.1 channel dysfunction in an Andersen-Tawil Syndrome variant through SUMOylation, and TAK-981 reverses this effect.

RvD1 and LXA4 inhibitory effects on cardiac voltage-gated potassium channels

This study investigates the effects of RvD1 and LXA4 on cardiac voltage-gated potassium channels in vitro and in silico, finding RvD1 more potent in inhibiting IKs and IKr.

Mechanism of Arrhythmogenesis Driven by Early After Depolarizations in Cardiac Tissue

This study develops a computational model of early after depolarizations (EADs) in cardiac tissue, showing that EADs can emerge through a discontinuous bifurcation leading to arrhythmogenic alternans without ectopic beats.

Knock-in Kcnh2 Rabbit Model of Long QT Syndrome Type-2, Epilepsy, and Sudden Death

This paper develops a knock-in rabbit model of LQT2 with KCNH2 deletion, showing prolonged QT intervals, seizures, and sudden death similar to human LQT2.

Distinct Excitability Properties of Cardiac Calbindin Neurons: Identifying a Unique Neuronal Population

The paper identifies a unique cardiac neuronal population expressing calbindin-D28k with distinct electrophysiological properties linked to arrhythmia susceptibility and cardiac pathologies.

MonoAlg3D: Enabling Cardiac Electrophysiology Digital Twins with an Efficient Open Source Scalable Solver on GPU Clusters

This paper introduces a GPU-based cardiac electrophysiology solver that enables fast and scalable simulations, demonstrating significant speedup and integration into a digital twin pipeline.

Computational Modeling of Effects of PKP2 Gene Therapy on Ventricular Conduction Properties in Arrhythmogenic Cardiomyopathy

This study uses computational models to show that low levels of PKP2 gene therapy transduction in ACM patients do not significantly improve conduction velocity but may increase conduction block risk with higher transduction.