Cardiac electrophysiology and arrhythmias

Human-engineered heart tissues recapitulate tissue-scale mechanisms underlying ventricular tachycardia

This paper demonstrates that human iPSC-derived engineered heart tissues can replicate tissue-scale mechanisms of ventricular tachycardia, including APD dispersion and reentry, previously only observed in intact hearts.

Calsequestrin localization at RyR2 clusters enables calcium wave propagation in ventricular myocytes

The paper develops a 3D computational model of mouse ventricular myocytes to show that calsequestrin2 (CASQ2) co-localization with RyR2 clusters is essential for reliable calcium wave propagation.

Conservation and divergence of transcriptional heterogeneity in the cardiac conduction system

This study compares transcriptional heterogeneity in the cardiac conduction system across species and developmental stages using single-cell and spatial transcriptomic data.

Cross-species architecture of the cardiac transverse-axial tubular system in mammals

The paper quantifies TATS ultrastructural features across eight mammalian species and finds correlations between TATS density, cardiomyocyte size, and physiological parameters like heart rate and lifespan.

PFKFB2 Gates a Relationship Between Cardiac Glycolytic Regulation and Electrophysiological Function

This paper shows that loss of PFKFB2 in cardiac cells leads to electrophysiological instability, including prolonged repolarization and ventricular tachyarrhythmia, linking glycolytic regulation to heart function.

Postmortem DNA methylation profiling uncovers signatures associated with left ventricle size

The paper identifies DNA methylation signatures in cardiac ventricles associated with left ventricle size using postmortem samples.

Kv11.1 (hERG) Protein Interaction Networks Connect Endocytic Trafficking to Polygenic Influences on Cardiac Repolarization

This study links polygenic scores for QT interval to changes in Kv11.1 protein interactions in hiPSC-CMs, revealing connections between genetic variants and endocytic trafficking mechanisms.

Resistance to Atrial Fibrillation Domestication and Mitochondrial Dysfunction in Sheep: a potential key role of the TCA Cycle and mitochondrial redox state

This study compares mitochondrial function and TCA cycle activity in sheep resistant to atrial fibrillation (AF) versus those that develop stable AF, finding differences in redox state and energy metabolism.

iMyocyte: A Web-Based Cellular Automata Platform for Real-Time Demonstration of Cardiac Reentry

iMyocyte is a web-based platform that uses a cellular automaton model to demonstrate cardiac reentry dynamics in real time, allowing students to manipulate parameters and observe effects on wave propagation.

Impaired S-nitrosylation of Cx43 prevents arrhythmogenicity and myocardial injury upon cardiac stress in Duchenne Muscular Dystrophy

This study shows that reducing S-nitrosylation of Cx43 in DMD mice prevents arrhythmias and myocardial injury under cardiac stress.

Transcriptional regulation of the TASK-1 potassium channel by ETV1 -Implications for atrial excitability

This study shows ETV1 directly regulates TASK-1 expression and contributes to atrial electrical remodelling, suggesting ETV1 as a potential therapeutic target for atrial fibrillation.

A broad set of synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG

This study investigates how synthetic cannabinoid receptor agonists affect cardiac ion channels, finding that most inhibit hERG and some also inhibit KV7.1/KCNE1.

Cardiac Pacemaker Cells Harness Stochastic Resonance to Ensure Fail-Safe Operation at Low Rates Bordering on Sinus Arrest

This study shows cardiac pacemaker cells use stochastic resonance to maintain rhythm at low heart rates, improving reliability in noisy conditions.

Elevated body temperature exacerbates arrhythmia and seizure-like activity in a zebrafish model of Timothy syndrome

This study shows that elevated temperature worsens arrhythmia and seizures in a zebrafish model of Timothy syndrome, suggesting fever may increase risk for TS patients.

In Silico Optimisation of Regenerative Cell Therapy in the Infarcted Human Ventricles to Mitigate Arrhythmic Burden

This study uses multiscale modeling to identify anti-arrhythmic strategies for cell therapy in infarcted human ventricles, showing that blocking specific currents and upregulating others reduces arrhythmias while maintaining calcium function.

Adeno-associated virus (AAV)-TBX18 does not generate biological pacemaker activity, unlike AAV-Hcn2

This study compares AAV-TBX18 and AAV-Hcn2 in generating biological pacemaker activity, finding TBX18 ineffective while Hcn2 induces robust ectopic pacing.

AI-enhanced cardiac digital twins extend drug proarrhythmic risk assessment through experimental data uncertainty propagation and overdose exploration: a loperamide case study

The paper uses AI-enhanced cardiac digital twins to assess drug proarrhythmic risk by propagating experimental uncertainty and simulating extreme exposures, finding sex-specific arrhythmogenic thresholds for loperamide.

Dual effects of nicotinamide on aging-related arrhythmia: protective at low dose, proarrhythmic at high doses

This study investigates the dual effects of nicotinamide on aging-related arrhythmia, showing protective effects at low doses and proarrhythmic effects at high doses in mouse and Drosophila models.

Acute sildenafil administration reduces susceptibility to induced atrial fibrillation in sheep

This study shows that acute sildenafil administration reduces atrial fibrillation susceptibility in sheep by prolonging refractory periods and altering electrophysiological properties.

A New Fight-or-Flight Pacemaker Mechanism via Ryanodine Receptor Abundance and Superclustering

This paper uses dSTORM to visualize RyR clusters in rabbit SANCs and develops a model showing superclustering and RyR density changes modulate APCL during βAR stimulation.

Wave propagation enhances extracellular signal strength in small excitable tissues

The paper shows that localized stimulation generating traveling waves enhances extracellular signal strength in hiPSC-CMs compared to uniform stimulation.

A novel RyR2-selective stabilizer prevents stress-induced ventricular arrhythmias without impairing cardiac function

Ryanozole, a RyR2-selective stabilizer, prevents stress-induced arrhythmias without impairing cardiac function in CPVT mouse models.

Endurance exercise remodels pulmonary vein sleeve myocytes and promotes a proarrhythmic atrial substrate

This study shows endurance exercise increases proarrhythmic remodeling in pulmonary vein sleeve myocytes and the PV-LA junction, contributing to atrial fibrillation susceptibility in athletes.

Myocardial STIM1 deficiency triggers mitochondrial fission to impair electrophysiological function and exacerbate post-MI remodeling

This study shows that reducing STIM1 in cardiomyocytes causes mitochondrial fragmentation and metabolic changes, leading to electrical instability and worsened heart function after a heart attack.

In silico assessment of arrhythmic risk following the implantation of engineered heart tissues in porcine hearts with varying infarct locations

This study assesses arrhythmic risk from engineered heart tissue implantation in porcine hearts with different infarct locations using computational models.

Beat-locked ATP microdomains in the sinoatrial node map a calcium-timed energetic hierarchy and regional pacemaker roles

The paper tracks beat-resolved ATP dynamics in mouse sinoatrial node myocytes, revealing distinct ATP-gain and -dip modes linked to regional pacemaker roles and energy supply.

Common Genetic Variants of The Cardiac Sodium Channel Alter Patient Response to Class 1b Antiarrhythmics

The paper shows that a common SCN5A variant, S1103Y, alters mexiletine's pharmacological response in induced pluripotent stem cell-derived cardiomyocytes, leading to proarrhythmic effects.

Novel insights into IKur modulation by Lgi3-4: Implications in atrial fibrillation

This study shows Lgi3-4 modulate IKur by interfering with KV1.5-KVβ interactions, contributing to atrial fibrillation pathophysiology.

CALM1, CALM2, and CALM3 expression and translation efficiency provide insight into the severity of calmodulinopathy

The paper compares the clinical impact of missense variants in CALM1, CALM2, and CALM3 genes by analyzing expression levels and translation efficiency in cardiac tissue.

Integrated multi-modal data analysis for computational modeling of healthy and location-dependent myocardial infarction conditions in porcine hearts

The paper develops porcine ventricular digital twins using multi-modal data to study myocardial infarction effects on cardiac function and ECG patterns.