Circadian rhythm and melatonin

Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression

This study shows that mealtime affects the daily rhythm of nuclear O-GlcNAc proteome in mice, which regulates hepatic gene expression through interactions with phosphorylation.

Prediction of Optimal Time of Day for Salmeterol Based on Circadian Phases of Target Proteins in the Target Tissues

This paper predicts the optimal time of day for salmeterol treatment in COPD based on circadian rhythms of target proteins in mice, showing gender-specific differences.

Diurnal rhythms with sunrise-induced oscular contractions suggest photosensitivity in the demosponge Halichondria panicea

The study observes light-induced diurnal rhythms in oscular contractions of Halichondria panicea, suggesting photosensitivity in a nerveless sponge.

Markovian State Models uncover Casein Kinase 1 dynamics that govern circadian period

This paper uses molecular dynamics simulations and Markovian State Models to analyze CK1 conformational dynamics, revealing how the tau mutant alters substrate selectivity and affects circadian period.

CLOCK-dependent pathway in a single pair of LNd neurons instruct circadian-independent interval timing behavior.

The paper identifies a CLK/CYC-dependent circuit in Drosophila that regulates interval timing independently of circadian rhythms.

Dissociating the Effects of Light at Night from Circadian Misalignment in a Neurodevelopmental Disorder Mouse Model Using Ultradian Light-Dark Cycles.

This study shows that adverse effects of nighttime light in a neurodevelopmental disorder mouse model depend on circadian disruption, not light exposure alone.

Circadian timing and entrainment properties of the SCN pacemaker in the PS19 mouse model of Tau pathology

This study examines circadian timing and entrainment in the SCN of PS19 mice with tauopathy, finding no significant disruptions in core circadian mechanisms despite tau pathology.

The earliest circadian clock in the mammalian brain emerges in the embryonic choroid plexus

The paper identifies the embryonic choroid plexus as the earliest circadian oscillator in the mammalian brain, showing bifurcation dynamics that couple to maternal rhythms.

Resynchronization of the biological clock using exposure to low oxygen levels in humans: an exploratory study

This study explores whether hypoxia or combined light/melatonin exposure can advance the human circadian phase, finding that light/melatonin had a significant effect while hypoxia did not.

Unpredictable circadian rhythm disruption in Wistar rats: biological and behavioural changes reflecting bipolar disorder pathophysiology

This study investigates the effects of unpredictable circadian disruption on locomotor activity and molecular markers in rats, finding biphasic behavioral changes and altered inflammatory, stress, and metabolic profiles.

Tandem association of CLOCK:BMAL1 complexes on DNA enables recruitment of CBP/p300 through multivalent interactions

The paper shows that tandem E-boxes enable CLOCK:BMAL1 to bind more sites on nucleosomes, promoting multivalent interactions with CBP/p300 to drive gene expression.

Synaptic Targets of Circadian Clock Neurons Influence Core Clock Parameters

This study identifies SLP316 neurons as synaptic targets of circadian clock neurons in Drosophila, showing that modulating their activity alters circadian period and behavior.

Melatonin mitigates oxidative stress and metabolic dysfunction induced by interleukin-6 and dopamine in SH-SY5Y cells

This study shows melatonin reduces oxidative stress and metabolic changes caused by IL-6 and dopamine in SH-SY5Y cells, suggesting potential therapeutic effects for bipolar disorder.

Performance of blood-based biomarkers for human circadian pacemaker phase: Training sets matter as much as feature selection methods

This study evaluates blood-based circadian biomarkers, showing that training data and protocols significantly affect performance, with feature selection methods playing a secondary role.

A Bayesian Framework for Genome-wide Circadian Rhythmicity Biomarker Detection

This paper introduces a Bayesian framework for detecting circadian rhythmicity biomarkers across the genome, showing improved false discovery rate control and performance in RNA-sequencing data.

miR-124 acts during Drosophila development to determine the phase of adult circadian behavior

This study shows that miR-124 during larval development is essential for proper phasing of adult circadian behavior in Drosophila by shaping the circadian neural network.

Circadian control of dopaminergic signaling to the mushroom body regulates sleep through rhythmic Pka-C1 transcription in Drosophila

This study identifies a circadian mechanism in Drosophila where rhythmic Pka-C1 transcription in mushroom body neurons regulates sleep through DA signaling and PKA activity.

Neuropeptide Dynamics Coordinate Layered Plasticity Mechanisms Adapting Drosophila Circadian Behavior to Changing Environment.

The paper reveals how environmental changes affect Drosophila circadian behavior through neuropeptide-driven adjustments in clock circuitry and protein function.

Hemoglobin in the diet modulates post-blood feeding behavioral rhythms and gene expression in Aedes aegypti

This study shows that hemoglobin intake affects post-blood feeding behavior and gene expression in Ae. aegypti mosquitoes by altering circadian rhythms and sleep patterns.

Chronotherapy as a Potential Strategy to Reduce Ifosfamide-Induced Encephalopathy: A Preclinical Study in a Murine Model

This study shows that sublethal ifosfamide toxicity varies by time of day in mice, with reduced organ damage at 13 HALO compared to other times.

Widespread temporal niche partitioning in an adaptive radiation of cichlid fishes

This study shows that temporal niche partitioning, through distinct activity patterns, contributed to the adaptive radiation of cichlid fishes in Lake Tanganyika.

MYC and Epithelial to Mesenchymal Transition (EMT) Independently Predict Circadian Rhythm Disruption in Lung Adenocarcinoma

This study identifies MYC expression and a mesenchymal cell state as independent predictors of circadian rhythm disruption in lung adenocarcinoma.

Astrocytic AMPK couples metabolic signals to hypothalamic circadian timing

This study shows astrocytic AMPK links metabolic signals to hypothalamic circadian timing by regulating phosphoproteome organization and behavior.

Meal timing is a critical factor for maintenance of gut homeostasis around the clock

This study shows that meal timing affects gut circadian rhythms, with interval feeding disrupting IEC clock transcripts and microbiota rhythms.

Effects of Cannabidiol to circadian period, sleep, life span, close-proximity rhythm, egg reproduction and motor function in Drosophila melanogaster

This study examines the effects of dietary CBD on circadian rhythms, sleep, lifespan, close-proximity rhythm, egg reproduction, and motor function in Drosophila melanogaster.

Reconstructed Cell-Type Specific Rhythms in Human Brain link Alzheimer's Pathology, Circadian Stress, and Ribosomal Disruption

The paper estimates circadian phases in human brain cells using single-nucleus RNA sequencing and finds disrupted ribosomal rhythms in Alzheimer's patients.

Machine learning models reveal environmental and genetic factors associated with the plant circadian clock

This study develops ChronoGauge, a machine learning model that estimates plant circadian time from transcriptomic data, enabling analysis of environmental and genetic factors affecting the circadian clock.

RHODOPSIN 7: An ancestral non-canonical photoreceptor shaping light-responsive behavior

The paper identifies RHODOPSIN 7 as a non-canonical light sensor in Drosophila that influences behavior and shows its evolutionary origins across panarthropods.

Perinatal circadian desynchronization disrupts sleep and prefrontal cortex function in adult offspring

This study shows that perinatal circadian desynchronization disrupts sleep and prefrontal cortex function in male mice but not females.

Age and Sex Influence Diurnal Memory Oscillations, Circadian Rhythmicity, and Per1 Expression

This study investigates how sex and age affect diurnal memory oscillations, circadian rhythms, and Per1 expression in mice, finding sex has a greater impact than age on circadian patterns and memory performance.