Circadian rhythm and melatonin

Glial control of sphingolipid levels sculpts diurnal remodeling of circadian circuits

This study shows that glial cells regulate sphingolipid levels to drive daily remodeling of circadian circuits in Drosophila.

Data-driven modelling captures dynamics of the circadian clock ofNeurospora crassa

The paper develops a data-driven model of the circadian clock in Neurospora crassa using luciferase reporter data to estimate parameters and reveal the role of FRQ maturation in circadian rhythms.

Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver

This study analyzes the circadian nuclear and cytoplasmic transcriptomes in mouse liver to understand temporal regulation of RNA processing and stability.

A role for the circadian transcription factor NPAS2 in the progressive loss of non-rapid eye movement sleep and increased arousal during fentanyl withdrawal in male mice

This study examines how fentanyl affects sleep architecture and how the circadian factor NPAS2 influences these changes during withdrawal in male mice.

Gene networks under circadian control exhibit diurnal organization in primate organs

The paper analyzes a baboon diurnal transcriptome atlas to show that 53.4% of genes are rhythmically expressed and that circadian gene networks exhibit daytime and nighttime modes with distinct biological functions.

The PAICE Suite Reveals Circadian Post-Transcriptional Timing of Non-Coding RNAs and Spliceosome Components in Mus musculus Macrophages

The paper introduces the PAICE suite to detect circadian oscillations in RNA and protein data, revealing post-transcriptional regulation and spliceosome timing in mouse macrophages.

Cryptochrome Stabilization Ameliorates Chronic Pain

The paper identifies a peripheral molecular clock in sensory neurons that regulates diurnal pain behaviors and shows that stabilizing cryptochromes reduces pain sensitivity.

Luxotonic signals in human prefrontal cortex as a possible substrate for effects of light on mood and cognition

The paper investigates whether light affects human prefrontal cortex activity through a pathway similar to that in animals, finding luminance-dependent signals in multiple brain regions.

Identification and characterisation of variable rhythms using CosinorPy

The paper extends the CosinorPy package to analyze complex rhythmic data with multiple peaks, changing rhythms, and time-shifted midlines, showing improved accuracy over existing methods.

A novel Smg6 mouse model reveals regulation of circadian period and daily CRY2 accumulation through the nonsense-mediated mRNA decay pathway

This study uses a Smg6 mouse model to show that NMD pathway downregulation affects circadian period length and daily CRY2 mRNA accumulation.

Nested calcium dynamics support daily cell unity and diversity in the suprachiasmatic nuclei of free-behaving mice

This study uses microendoscopic Ca2+ imaging to show that SCN neurons in vivo exhibit both fast Ca2+ spikes and slow baseline changes, revealing diverse activity patterns within a coordinated circadian network.

DNA methylation is a widespread mechanism of light-induced circadian clock period plasticity

The paper shows DNA methylation in the SCN mediates light-induced circadian period after-effects, both from photoperiod changes and single light pulses.

Connectomic Analysis of the Drosophila Lateral Neuron Clock Cells Reveals the Synaptic Basis of Functional Pacemaker Classes.

The paper analyzes synaptic connectivity in Drosophila lateral neuron clock cells to identify distinct connectomic types and their roles in circadian timekeeping.

Prediction of mammalian tissue-specific CLOCK-BMAL1 binding to E-box motifs

The paper develops tissue-specific models to predict CLOCK-BMAL1 binding to E-box motifs using DNA sequence, shape, and histone modification features in mouse liver, heart, and kidney.

Long wavelength light reduces the negative consequences of dim light at night in the Cntnap2 mouse model of autism.

This study shows that long-wavelength light reduces negative effects of dim light at night in Cntnap2 mice, improving activity rhythms and autistic behaviors.

Statistical Methods for Detecting Circadian Rhythmicity and Differential Circadian Patterns with Repeated Measurement in Transcriptomic Applications

The paper develops linear mixed model methods to detect circadian rhythmicity and differential circadian patterns using repeated measurements, showing improved statistical power and validity.

Inter-layer and inter-subject variability of circadian gene expression in human skin

This study examines circadian gene expression variability in human skin layers and identifies layer-specific biomarkers for internal clock phase.

PERIOD phosphoclusters control temperature compensation of the Drosophila circadian clock

This paper identifies the role of PER phosphodegron residues in temperature compensation of the Drosophila circadian clock through genetic and biochemical experiments.

Physical activity increases neuronal activity in the circadian clock of diurnal Arvicanthis ansorgei

The paper examines how physical activity affects the circadian clock in diurnal rodents, finding that activity increases SCN neuronal firing rather than suppressing it, unlike in nocturnal animals.

The Arabidopsis Framework Model version 2 predicts the organism-level effects of circadian clock gene mis-regulation

The paper updates a circadian clock model for Arabidopsis to predict phenotype effects of gene mis-regulation using metabolic and physiological data.

HSP40 overexpression in pacemaker neurons protects against circadian dysfunction in a Drosophila model of Huntington's Disease

This study shows that overexpression of HSP40 in pacemaker neurons rescues circadian dysfunction in a Drosophila Huntington's Disease model by restoring circadian proteins and reducing Huntingtin inclusion load.

Two light sensors decode moonlight versus sunlight to adjust a plastic circadian/circalunidian clock to moon phase

The paper identifies two light sensors in Platynereis dumerilii that distinguish moonlight from sunlight to adjust a circadian clock to moon phase.

The ultradian transcriptome of the human prefrontal cortex and abnormalities in schizophrenia

The paper identifies 12-hour ultradian rhythms in the human prefrontal cortex and shows disruptions in schizophrenia affecting genes related to protein processing and mitochondrial function.

Regulation of PDF Receptor signaling controlling daily locomotor rhythms in Drosophila

This study investigates how PDF receptor signaling is terminated in Drosophila, showing that phosphorylation sites in its C-terminal tail regulate behavioral rhythms and that specific mutations alter these rhythms in a day-length-dependent manner.

Period Doubling Bifurcations in a Forced Cell-Free Genetic Oscillator

The paper experimentally demonstrates period doubling and quadrupling in a synthetic genetic oscillator under external perturbations.

The canonical HPA axis contributes to locomotion during photoadaptation but is not required

This study investigates the role of the HPA axis in locomotor adaptation during photoadaptation in zebrafish, finding that it is necessary for rapid adaptation to short light exposures but not for longer exposures.

Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats

The paper investigates the association between Clock gene polymorphism and annual cycle timing in stonechats across different populations, finding population-specific links between repeat length and timing.

Insulin-Like Growth Factor I Couples Metabolism With Circadian Activity Through Hypothalamic Orexin Neurons

This study shows that IGF-I regulates circadian feeding behavior and metabolism via hypothalamic orexin neurons in mice.

Circadian pacemaker neurons display co-phasic rhythms in basal calcium level and in fast calcium fluctuations

The paper shows that circadian pacemaker neurons in Drosophila exhibit co-phasic rhythms in basal calcium levels and fast calcium fluctuations, driven by IP3R and T-type channels respectively.

Intrinsically photosensitive retinal ganglion cells evade temporal filtering to encode environmental light intensity

The paper investigates how intrinsically photosensitive retinal ganglion cells (ipRGCs) encode environmental light intensity by showing their unique synaptic drive and resistance to postsynaptic filtering.