Circadian rhythm and melatonin

The Retinal Basis of Photoaversion in Neonatal Mice

This study identifies M1 ipRGCs as the primary driver of photoaversion in neonatal mice by showing their unique photosensitivity and behavioral relevance.

A subtype of melanopsin ganglion cells encodes ground luminance

The paper identifies a subtype of ipRGCs projecting to the SON and shows they encode ground luminance through a non-overlapping tiled mosaic in the dorsal retina.

A natural timeless polymorphism allowing circadian clock synchronization in 'white nights'

The paper shows that a natural allele of the timeless gene allows Drosophila to synchronize circadian clocks to temperature cycles in constant light.

Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder

The paper investigates molecular rhythm alterations in the prefrontal cortex and nucleus accumbens of individuals with opioid use disorder, finding distinct rhythmic transcript patterns and associations with sleep and neurotransmitter systems.

The photobiology of the human circadian clock

This study directly measures the light response of the human SCN and finds that light suppresses SCN activity across multiple wavelengths, suggesting a need to revise light exposure strategies.

Quantification of circadian interactions and protein abundance defines a mechanism for operational stability of the circadian clock

The paper quantifies circadian interactions and protein abundance to reveal mechanisms maintaining the circadian clock's operational stability.

PRL1 and CK2 collaborate to time morning and evening phase in short photoperiods

This study shows PRL-1 and CK2 collaborate in PDF neurons to regulate morning and evening phase timing under short photoperiod conditions.

Chloride oscillation in pacemaker neurons regulates circadian rhythms through a chloride-sensing WNK kinase signaling cascade

The paper shows that chloride levels in Drosophila pacemaker neurons regulate circadian rhythms via a WNK-Fray signaling cascade and potassium channel activity.

The opposing Chloride Cotransporters KCC and NKCC control locomotor activity inconstant light and during long days.

This study shows that KCC and NKCC cotransporters regulate GABA responses and locomotor activity in Drosophila under constant light and long days through a feedback loop involving Wnk and Fray kinases.

period Translation as a Core Mechanism Controlling Temperature Compensation in an Animal Circadian Clock

This study identifies translation factors that mediate temperature compensation in the circadian clock by altering the temperature dependence of PER protein oscillations.

A Unified Model for Entrainment by Circadian Clocks: Dynamic Circadian Integrated Response Characteristic (dCiRC)

The paper develops a unified model, dCiRC, to predict circadian entrainment phase by integrating parametric and non-parametric aspects of circadian clock responses to light.

Developmental emergence of sleep rhythms enables long-term memory capabilities in Drosophila

This study identifies when circadian sleep emerges in Drosophila larvae and shows its role in enabling long-term memory.

The Clock:cycle complex is a major transcriptional regulator of Drosophila photoreceptors that protects the eye from retinal degeneration and oxidative stress

This study identifies Clock and cycle as neuroprotective circadian regulators in Drosophila photoreceptors that prevent retinal degeneration and oxidative stress during aging.

Circadian Rhythm Disruption Results in Visual Dysfunction

This study shows that circadian rhythm disruption in mice leads to visual dysfunction, including retinal thinning and reduced visual acuity, with behavior-dependent effects on retinal proteins.

Circadian desynchronization attenuates information throughput independent of daily rhythms in prefrontal cortex pyramidal neurons in mice

This study shows circadian desynchronization reduces information throughput in prefrontal cortex neurons in mice, independent of daily rhythms, through GIRK channel sensitivity changes.

Rhythmic Cilium in SCN Neuron is a Gatekeeper for the Intrinsic Circadian Clock

The paper identifies rhythmic cilia in SCN neurons as critical for intercellular coupling and maintaining the circadian clock in mice.

The Suprachiasmatic Nucleus Regulates Anxiety-Like Behavior in Mice

This study shows that manipulating SCN neural activity in mice affects anxiety-like behavior but not depressive-like behavior, with dampened activity rhythms correlating with increased anxiety.

Experimental Design and Power Calculation in Omics Circadian Rhythmicity Detection

This paper introduces CircaPower, a statistical method for power calculation in circadian rhythmicity detection, validated through simulations and real data.

Radical pairs can explain magnetic field and lithium effects on the circadian clock

The paper shows that magnetic fields and lithium affect circadian rhythms through radical pair mechanisms in cryptochromes, reproducing experimental results and predicting isotope-dependent lithium effects.

A spatio-temporal model to reveal oscillatorphenotypes in molecular clocks: Parameterestimation elucidates circadian gene transcriptiondynamics in single-cells

The paper develops a spatio-temporal model to analyze circadian gene expression dynamics in single cells, revealing spatial and temporal differences in oscillation robustness and regulatory profiles in mouse SCN tissue.

Light sets the brain's daily clock by regional quickening and slowing of the molecular clockworks at dawn and dusk

The paper shows light adjusts the brain's circadian clock by altering molecular clockwaveforms in specific SCN regions to simulate dawn and dusk, enabling seasonal timekeeping.

Methods for detecting PER2::LUCIFERASE bioluminescence rhythms in freely moving mice

The paper describes methods to detect PER2::LUCIFERASE bioluminescence rhythms in freely moving mice using a LumiCycle In Vivo system and evaluates substrate delivery methods.

Daily rhythms in the transcriptomes of the human parasite Schistosoma mansoni

This study identifies daily transcriptomic rhythms in Schistosoma mansoni, revealing rhythmic gene expression patterns and their potential relevance to parasite survival and drug targets.

Identification of biological processes and signaling pathways for the knockout of REV-ERB in mouse brain

The paper identifies signaling pathways and biological processes affected by REV-ERB knockout in mouse brain using transcriptomic analysis.

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1

This study shows NF-κB interacts with BMAL1 to regulate circadian clock function through transcriptional repression at E-box elements.

Conformational Changes in the Negative Arm of the Circadian Clock Correlate with Dynamic Interactomes Involved in Post-transcriptionally Regulated Processes

The paper investigates conformational changes in circadian clock negative arm proteins and their role in post-transcriptional regulation through dynamic interactomes.

Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock

Intrinsic circadian timekeeping properties of the thalamic lateral geniculate nucleus

This study identifies autonomous circadian timekeeping mechanisms in the lateral geniculate nucleus (LGN) of the thalamus, showing intrinsic clock gene expression and light-entrainable oscillations in specific subregions.

Circadian protein regulation in the green lineage II. The clock gene circuit controls a phospho-dawn in Arabidopsis thaliana.

The paper presents circadian proteomic and phosphoproteomic data from Arabidopsis thaliana, showing that most rhythmic phosphorylation occurs at subjective dawn and is controlled by the clock gene circuit.

Violet light modulates the central nervous system to regulate memory and mood

This study shows that violet light improves memory and mood in aged mice by activating OPN5-positive retinal ganglion cells and modulating brain regions like the habenula.