Circadian rhythm and melatonin

Dysregulated mammalian estrus cycle rescued by timed activation of VIP neurons in the circadian pacemaker and late afternoon light exposure

The paper shows that timed activation of VIP neurons in the SCN and late afternoon light exposure can rescue dysregulated estrus cycles in mice.

A novel supplemental circadian feedback loop in CA1 mediates mood-related behaviors

This study identifies a novel circadian feedback loop between Per1 and Per2 genes in CA1 that mediates mood-related behaviors, with Per1 promoting Per2 expression and Per2 inhibiting Per1, contributing to depression and bipolar disorder pathophysiology.

A role for gene expression and mRNA stability in nutritional compensation of the circadian clock

This study identifies novel regulators of Nutritional Compensation in the circadian clock of Neurospora crassa and shows conservation in mammalian cells.

Defining the age-dependent and tissue-specific circadian transcriptome in male mice

This study identifies age-dependent and tissue-specific changes in the circadian transcriptome of male mice, showing reduced rhythmic gene expression and increased variability in aged tissues.

Polyphasic circadian neural circuits drive differential activities in multiple downstream rhythmic centers

The paper identifies three distinct circadian phases in Drosophila pacemaker networks and shows how they drive rhythmic activity in downstream neurons.

Individual light history matters to cope with the Antarctic summer

This study examines how individual light history affects circadian phase shifts in response to increased light exposure in the Antarctic summer.

Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection

This study shows that sleep deprivation alters the mouse lung transcriptome, suppressing immune systems and activating SARS-CoV-2 replication genes, increasing viral infection risk.

Mating disrupts morning anticipation in Drosophila melanogaster females 2

This study shows that mating in Drosophila females disrupts their ability to anticipate the night-day transition, mediated by sex peptide acting on PPK+ neurons and affecting PDF levels.

The circadian clock gene bmal1 is necessary for co-ordinated circatidal rhythms in the marine isopod Eurydice pulchra (Leach).

This study shows that the circadian clock gene bmal1 is necessary for circatidal rhythms in Eurydice pulchra, while other negative regulators are not.

Genome-wide gene by environment study of time spent in daylight and chronotype identifies emerging genetic architecture underlying light sensitivity

This study identifies a genetic variant associated with light sensitivity by analyzing the interaction between daylight exposure and chronotype in a large cohort.

Discovery and Visualization of Age-dependent Patterns in the Diurnal Transcriptome of Drosophila

The paper identifies age-dependent changes in diurnal transcriptome rhythms in Drosophila using a novel Fourier-based method, revealing shifts in core clock and pathway rhythmicity.

Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice

The paper identifies a small molecule, M47, that destabilizes CRY1 and extends lifespan in p53 knockout mice by enhancing apoptosis and reducing CRY1 levels.

Tempo: an unsupervised Bayesian algorithm for circadian phase inference in single-cell transcriptomics

Tempo is a Bayesian method for inferring circadian phase from scRNA-seq data, providing accurate estimates and uncertainty quantification.

Gene expression signatures predict circadian rhythms in oncogenic pathways

The paper uses gene expression signatures to predict circadian rhythms in EGFR, PI3K, and p53 pathways in mouse liver across multiple datasets.

An in silico genome-wide screen for circadian clock strength in human samples

This paper introduces LTM, an in silico method to identify genetic influences on circadian clock function using gene expression data, and finds the cell cycle and extracellular matrix pathways are strongly associated with clock strength in human tissues.

The circadian clock conveys thermal and photoperiodic cues to modulate EYES ABSENT via the neuropeptide PDF to regulate seasonal physiology

This study shows that PDF signaling negatively modulates EYA levels to regulate seasonal physiology in Drosophila by integrating thermal and photoperiodic cues.

A role for thalamic projection GABAergic neurons in circadian responses to light

This study identifies the role of thalamic GABAergic neurons in circadian responses to light, showing their involvement in vigilance state transitions and dim light entrainment.

Circadian clock disruption promotes the degeneration of dopaminergic neurons

This study shows that disrupting circadian clocks in Drosophila worsens dopaminergic neuron degeneration and increases mortality under oxidative stress.

The clock gene Per1 expression may exert diurnal control over hippocampal memory consolidation

This study identifies Per1 as a circadian gene that modulates memory consolidation in the dorsal hippocampus, showing diurnal effects on long-term memory performance in mice.

Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster

The paper develops a method to measure circadian clocks in live Drosophila and shows that peripheral clocks can oscillate independently of the brain clock.

Knockouts of positive and negative elements of the circadian clock disrupt photoperiodic diapause induction in the silkworm, Bombyx mori

This study shows that knocking out core circadian clock genes in silkworms disrupts photoperiodic diapause induction during both embryonic and larval stages.

Structure-function analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation

This study identifies clusters of phosphorylation sites on FRQ that determine circadian period length and temperature compensation through mutagenesis and reporter assays.

A circadian-like gene network regulates heterochronic miRNA transcription in C. elegans

The paper shows that NHR-85 and NHR-23 heterodimers regulate lin-4 miRNA transcription pulses in C. elegans, similar to circadian clock mechanisms in mammals.

Ultrastructure of synaptic connectivity within sub-regions of the SCN revealed by genetically encoded EM tag and SBEM

The paper maps synaptic connectivity patterns in the SCN core and shell using EM techniques, showing the shell receives denser mRGC inputs than the core.

The impact of Mendelian sleep and circadian genetic variants in a population setting

This study examines the impact of Mendelian sleep and circadian genetic variants in population cohorts and finds no strong associations with extreme sleep traits, though some variants show minor effects.

A Cryptochrome adopts distinct moon- and sunlight states and functions as moonlight interpreter in monthly oscillator entrainment

This paper identifies L-Cryptochrome as a moonlight interpreter that distinguishes between sun- and moonlight to regulate monthly oscillator entrainment in Platynereis dumerilii.

SleepMat: A New Behavioral Analysis Software Program for Sleep and Circadian Rhythms

SleepMat is a new software program that provides a broader range of circadian and sleep parameter analyses for Drosophila data.

Melatonin suppression does not automatically alter sleepiness, vigilance, sensory processing, or sleep

This study investigates whether high-melanopic light affects sleep and vigilance, finding no differential effects despite melatonin suppression.

Sex-specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal, and analgesia

This study investigates the sex-specific role of NPAS2 in fentanyl-induced analgesia, tolerance, hyperalgesia, and dependence using NPAS2-deficient mice.

Dopamine and GPCR-mediated modulation of DN1 clock neurons gates the circadian timing of sleep

The paper identifies dopamine and GPCR-mediated modulation in Drosophila clock neurons that regulate sleep timing.