Circadian rhythm and melatonin

Pre-task light exposure primes higher-order cognition and preserves mood

This study shows that pre-task light exposure improves cognitive performance and mood without affecting alertness.

Fruit flies actively restart their circadian clock by proactively shaping their environment

This study shows fruit flies actively maintain circadian rhythms by shaping their environment, leading to better sleep and rhythmic behavior.

Analysis of human visual experience data

This paper provides a tutorial for analyzing visual experience datasets using reproducible workflows and the LightLogR R package, focusing on chronobiology and myopia research.

Circadian clock control of translation fidelity through MetRS-mediated methionine misincorporation

The paper shows that the circadian clock regulates methionine misincorporation into proteins, linking it to oxidative stress resistance through phosphorylation of MetRS.

Emergent multidien cycles from partial circadian synchrony

The paper proposes that multidien cycles emerge from partial synchrony of circadian oscillators and demonstrates this using a ring model of coupled oscillators.

Prenatal circadian rhythm disruption induces sex-specific substance use and mood-related phenotypes in mice

This study shows that prenatal circadian rhythm disruption in mice leads to sex-specific behavioral changes in adulthood, with females showing mood-related issues and males showing substance use-like behaviors.

Topical application of a cryptochrome and REV-ERB inhibitor on human skin increases epidermal XPA and WEE1 expression

This study shows that a cryptochrome and REV-ERB inhibitor increases XPA and WEE1 expression in human skin, suggesting potential to modulate UV response.

Divergent molecular and circuit mechanisms underlie light entrainment of retinal and suprachiasmatic nucleus circadian clocks

This study identifies divergent molecular and circuit mechanisms for light entrainment in retinal and SCN circadian clocks using mouse models and transcriptomic analysis.

Cell-type targeted CRISPR/Cas9 Clock knockdown in mouse VTA dopamine neurons alter sleep, behavior, and cellular excitability

This study uses CRISPR/Cas9 to knock down Clock in mouse VTA dopamine neurons, revealing effects on sleep, behavior, and excitability linked to bipolar disorder.

Nucleotide-driven KaiC dynamics coordinate the core properties of the cyanobacterial circadian clock

This study identifies ADP release as the rate-limiting step in the KaiC ATPase cycle and shows how the nucleotide cycle integrates core circadian clock properties in cyanobacteria.

Humidity as a potential zeitgeber for circadian entrainment of insect systems

The paper investigates how humidity affects circadian rhythms in insects, finding that it can entrain activity patterns, though not universally across all species.

Altered Lighting Conditions Elicit Sex-Specific Circadian Behaviors in Diurnal Grass Rats

This study examines sex-specific circadian behaviors in diurnal grass rats under altered lighting conditions, revealing distinct patterns and responses between males and females.

A missense mutation in FBXL3 links circadian regulation to out-of-season estrus in sheep

This study identifies a missense mutation in FBXL3 linked to seasonal breeding in sheep, showing it affects circadian rhythms and estrus patterns.

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof-of-Concept Synthesis of Landscape-Level Regulation

The paper identifies a network of 26 genes at the intersection of melatonin signaling and phase separation, showing melatonin suppresses oncogenic drivers and correlates with poorer survival in breast and gastric cancers.

Nuclear CK1δ as a Critical Determinant of PER:CRY Complex Dynamics and Circadian Period

This study investigates the role of nuclear CK1δ in PER:CRY complex dynamics and circadian period regulation, showing its impact on complex formation and nuclear clearance of PER2.

Local and non-local impacts of intra-hexamer interactions on temperature compensation of KaiC

The paper identifies amino acid residues in KaiC that regulate temperature compensation through local and non-local interactions affecting ATPase activity.

Circadian disruption alters hepatic calcium hemostasis, endocannabinoidome and mitochondria through N -docosahexaenoyl ethanolamide-GPR110 signaling

This study shows circadian disruption affects hepatic lipid profiles, mitochondrial function, and calcium signaling via DHEA-GPR110 pathway in hepatocytes.

Integration of zebrafish pineal transcriptomes reveals cell type-specific timing

The paper integrates zebrafish pineal transcriptomes to identify cell-type-specific circadian rhythms and light responses in photoreceptors and neurons.

Development of circadian immune regulation in early life

This study investigates how circadian immune regulation develops during postnatal life, finding that leukocyte rhythmicity and peripheral clocks mature progressively through development.

The plant circadian clock exerts stronger control over the diel proteome than the transcriptome

The paper shows the plant circadian clock has stronger control over the diel proteome than the transcriptome, with specific clock genes influencing proteome rhythms more than transcripts.

Modelling the effect of V1a receptor antagonism and its potential therapeutic effect in circadian disorders

This paper models the effect of V1a receptor antagonism on circadian rhythms in mice, showing it accelerates resynchronization and suggests therapeutic potential for circadian disorders.

Timed Secreted Proteomes Reveal Regulation of Hepatokines by the Liver Circadian Clock

The paper identifies time-of-day-dependent liver protein secretion in mice, revealing endostatin's role in regulating adipose metabolism through circadian control.

GAPVD1 regulates CSNK1D-dependent PER2 FASP phosphorylation

This paper identifies GAPVD1 as a scaffold that modulates the PER2-CSNK1D interaction by weakening their association and reducing PER2 FASP phosphorylation.

Identification of Genomic Loci Associated with Cellular Rhythms in Diversity Outbred Mice

The paper identifies genomic loci associated with cellular rhythms in Diversity Outbred mice using QTL mapping and connects them to circadian regulation and complex traits.

c-MYC is Transcribed in a Circadian Manner and Acts as a Clock Disruptor whose Timing Minimizes its Impacts

This paper demonstrates that c-MYC is expressed in a circadian manner and acts as a clock disruptor, with its timing minimizing its negative impact on circadian rhythms.

Circadian misalignment underlies immune escape in breast cancer

The paper identifies circadian misalignment between cancer and immune cells in breast tumors as a mechanism of immune evasion and therapeutic resistance.

Visualization of neuronal morphology of the suprachiasmatic nucleus vasopressin neurons by Cre/FLPe-based genetic two-step sparse labelling - GT-SPARCL

The paper introduces GT-SPARCL, a genetic method for low-density neuronal labeling in mice, and applies it to reveal morphological subtypes of AVP neurons in the SCN.

The slow-acting G-protein Gz defines the duration of circadian rest time

This study shows that Gz G-protein regulates the duration of circadian rest time by modulating cAMP-PKA activity and transcriptome remodeling in the SCN.

The astrocyte-enriched gene Tmem44 regulates circadian protein translation in mouse astrocytes

This study identifies Tmem44 as a gene regulating circadian protein translation in mouse astrocytes by controlling translational efficiency and clock protein abundance.

Roles for Phosphatase PP4 in Rhythmicity and Compensation in the Neurospora Circadian System

This study investigates the role of phosphatase PP4 in the Neurospora circadian clock, showing it regulates period length and compensation mechanisms.