Circadian rhythm and melatonin

Region specific Per1 induction dissociates circadian and mood responses to light

The paper shows that light's effects on circadian rhythms and mood are mediated by distinct Per1 pathways in the SCN and LHb, respectively.

A direct SCN-to-DMH output pathway organizes circadian behavioral timing

This study identifies a direct SCN-to-DMH pathway that organizes circadian locomotor timing by showing that intact DMH neurons, not local molecular clocks, are required for rhythmic behavior.

Genetic variants affect diurnal glucose levels throughout the day

The paper identifies genetic variants associated with diurnal glucose levels and their role in type 2 diabetes risk.

A Screen To Identify Protein Phosphatases with Roles in Circadian Period, Temperature Compensation and Output in the Neurospora Circadian Clock

The paper identifies protein phosphatases involved in circadian period, temperature compensation, and output in Neurospora by analyzing 39 non-essential phosphatases.

DHHC3-dependent S-Acylation of CRY1 regulates its subcellular localization and repressor function in the circadian clock

This study identifies S-acylation of CRY1 as a critical post-translational modification regulated by DHHC3, essential for its nuclear localization and repressor function in the circadian clock.

Stage-Specific Regulation of DNA Damage Repair by the Circadian Regulator, CRY1, in Prostate Cancer

This study identifies CRY1 as a stage-specific regulator of DNA damage repair in prostate cancer, showing it promotes NHEJ/BER in hormone-sensitive disease and HR in castration-resistant disease.

Rhythmic Nuclear Import Mediated by Importins Regulates the Neurospora Circadian Clock.

This study shows that rhythmic nuclear import mediated by importins regulates the Neurospora circadian clock by affecting FRQ and WCC dynamics and timing.

Longitudinal tracking reveals developmental transitions in zebrafish clock gene expression

The paper tracks zebrafish clock gene expression over development and identifies distinct regulatory programs for per3 and per2.

Circadian Clock Programming of Anticipatory Antiviral Immunity Gates Enteric Virus Infection Susceptibility

The paper shows that the circadian clock programs antiviral immunity in the intestine, affecting susceptibility to enteric virus infection based on the time of day.

Co-expression network analysis reveals repression of Igf2bp2 by REV-ERBβ in skeletal muscle

The paper identifies Igf2bp2 as a target of REV-ERBβ repression in skeletal muscle using co-expression network analysis and functional experiments.

Identification of a Third Period-tuning Site in Cyanobacterial Clock Protein KaiC

This paper identifies the 322nd residue of KaiC as a third period-tuning site, showing that mutations at this site can alter circadian period length through effects on ATPase activity.

High-fat diet-induced obesity differentially alters circadian gene expression across peripheral tissues

This study shows that high-fat diet-induced obesity changes circadian gene expression differently in skeletal muscle, liver, and white adipose tissue.

Dissecting the Network Architecture of a Plant Circadian Clock Model: Identifying Key Regulatory Mechanisms and Essential Interactions

The paper develops a mathematical model of the plant circadian clock and identifies key regulatory mechanisms and essential interactions through computational analysis.

The Case for Kinases:A Phosphorylation Driven Model for Circadian Temperature Compensation

The paper investigates the role of kinases in temperature compensation of circadian rhythms in Neurospora, finding that Casein Kinase I and II have temperature-dependent regulatory roles on FRQ phosphorylation.

Mettl5 coordinates protein production and degradation of PERIOD to regulate sleep in Drosophila

This study shows that Mettl5 regulates sleep in Drosophila by affecting PERIOD protein levels through translational control and proteasome function.

In vivo BMAL1 occupancy mapping using MACS-Calling Cards reveals disease-associated retargeting in Cln3Δex7/8 astrocytes

The paper introduces MACS-Calling Cards to map astrocyte-specific TF occupancy in vivo and finds BMAL1 binding is redistributed in a neurodegenerative disease model due to loss of cooperative TF interactions.

Methionine Deprivation-induced Reprogramming of Hepatic Rhythms Is Mediated by Glucocorticoid Receptor

This study shows that methionine deprivation in mice reprograms hepatic circadian rhythms via glucocorticoid receptor mechanisms.

Comparative circadian transcriptome analysis reveals dampened and phase-advanced rhythms in sun-exposed human skin

This study compares circadian rhythms in photoprotected and photoexposed human skin, finding reduced rhythmic genes and advanced peak times in sun-exposed skin.

An underlying bistability sets amplitude and explains temperature compensation in the cyanobacterial circadian clock

The paper identifies bistability in the cyanobacterial circadian clock as a mechanism for temperature compensation, linking it to amplitude regulation and phosphorylation dynamics.

Circadian disruption induces sex-specific Alzheimer's pathophysiology and immune cell reprogramming

This study shows circadian disruption causes sex-specific changes in Alzheimer's pathology and immune cell behavior in mice.

Gamma CV as a Marker of Circadian Disruption in C57BL/6J Mice: Correlating Neural Desynchrony with Locomotor, Thermal, and Sleep Dysrhythmia across a Spectrum of Circadian Rhythms Disruption paradigms.

This study identifies Gamma CV as a sensitive marker of circadian disruption in mice by analyzing neural, thermal, and locomotor data across different circadian stress paradigms.

Inter-hemispheric connections modulate splitting in a computational model of the bilateral SCN

This study investigates how inter-hemispheric connections in a computational model of the SCN influence splitting dynamics under different lighting conditions.

Alcohol and Opioids Modulate Excitatory Inputs to the SCN

This study shows that alcohol and opioids modulate glutamatergic input to the SCN, revealing the SCN as a target of depressant substances and highlighting glutamatergic transmission as a vulnerability in circadian dysregulation.

Znf804a is a regulator of circadian behaviors in zebrafish

This study links the schizophrenia risk gene znf804a to circadian behaviors in zebrafish by showing altered gene expression and transcript processing in mutants.

Quercetin and Fisetin activate circadian clock via RORα and inhibit adipocyte growth

This study identifies Quercetin and Fisetin as clock-activating compounds that inhibit adipocyte growth and lipid metabolism via RORα activation.

Sleep regulates hepatic neutrophil trafficking by modulating uric acid metabolism via sympathetic nervous system activity

This study shows that sleep loss triggers hepatic inflammation through a sympathetic-metabolic-immune axis by increasing uric acid synthesis and neutrophil recruitment.

A high-resolution, sex-stratified atlas of transcriptional and alternative splicing dynamics in the fasting mouse liver

This paper presents a high-resolution transcriptomic atlas of fasting mouse liver, revealing transcriptional and alternative splicing dynamics, circadian changes, and sex differences.

YIPPEE/YPEL5 regulates circadian period by modulating PER ubiquitination and stability

This study identifies YIPPEE/YPEL5 as a conserved regulator of circadian rhythms by modulating PER/PER2 ubiquitination and stability, affecting circadian period length.

The Phenotypic Landscape of a Circadian Clock

The paper uses a deep sequencing assay to analyze how mutations affect circadian clock phenotypes, revealing factorized oscillator properties and mutation-specific effects on period and amplitude.

Bidirectional regulation between circadian feeding behavior and specialized midgut clocks in Drosophila

This study shows how midgut clocks and feeding behavior regulate each other in Drosophila, with implications for metabolic health.