Angiogenesis and VEGF in Cancer

Strong and Significant Associations of Single Nucleotide Variants (SNVs) in the Promoter and 3'-Untranslated Region (3'-UTR) of Vascular Endothelial Growth Factor (VEGF) Gene with Head and Neck Cancers

This study identifies significant associations between VEGF SNVs and head and neck cancer risk and tumor characteristics in a South Asian population.

Endothelial cell polarity and extracellular matrix production rely on functional ATP6AP2 during developmental and pathological angiogenesis

This study shows ATP6AP2 is essential for endothelial cell polarity and extracellular matrix production during both normal and disease-related blood vessel growth.

Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip 1

This study investigates the role of Rasip1 in endothelial cell behaviors during angiogenesis and anastomosis in zebrafish, revealing its critical function in cell pairing and junction stability.

Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis

The paper evaluates how vascular branching morphology affects blood flow and oxygen transport during angiogenesis using computational simulations and mouse models.

VEGFC induced cell cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells

This study shows that VEGFC induces cell-cycle arrest in endothelial cells, promoting sprouting and differentiation in venous and lymphatic vessels.

Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

This study uses a zebrafish Erk biosensor to live-image dynamic Erk-signalling events during regenerative angiogenesis, revealing sequential Ca2+- and Vegfr-dependent mechanisms.

Synaptotagmin-like protein 2a regulates lumen formation via Weibel-Palade body apical secretion of angiopoietin-2 during angiogenesis

This study shows that Slp2a is essential for vascular lumen formation by regulating Weibel-Palade body exocytosis and angiopoietin-2 release during angiogenesis.

Nucleolin is expressed in human fetal brain development and reactivated in human glial brain tumors regulating angiogenesis and vascular metabolism

This study identifies Nucleolin as a factor reactivated in gliomas that promotes angiogenesis and endothelial metabolism by regulating glycolysis through p53-TIGAR-HK2.

Antifungal benzimidazoles disrupt vasculature by targeting one of nine β-tubulins

This study identifies TUBB8 as the molecular target of benzimidazoles, revealing their mechanism of vascular disruption and potential clinical applications.

Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways

This study shows that oligodendroglial HIF regulates CNS angiogenesis via VEGF-dependent signaling, independent of Wnt, and reveals a glial cell type-specific HIF-Wnt axis.

Whole Genome and Embryo Transcriptome Analysis of Vertebrate Identifies nxhl Controlling Angiogenesis by Targeting VE-PTP

This study identifies nxhl as a novel upstream regulator of VE-PTP in angiogenesis by interacting with NCL, revealing a new signaling pathway with therapeutic potential for angiogenesis-dependent diseases.

Redundant function of Ets1 and Ets2 in regulating M-phase progression in post-natal angiogenesis

This study shows that ETS1 and ETS2 redundantly regulate M-phase progression and cell survival in post-natal angiogenesis by controlling G2/M regulators and anti-apoptotic genes.

Epithelial Vegfa specifies a distinct endothelial population in the mouse lung

The paper shows that Vegfa from alveolar type 1 cells specifies a distinct endothelial population in the mouse lung, marked by Car4 and involved in alveologenesis.

Pericytes enable effective angiogenesis in the presence of pro inflammatory signals

The paper shows that pericytes enhance angiogenesis under high TNF doses, with a mathematical model explaining the switch from pro- to anti-angiogenic effects of TNF.

Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells

This study shows that Caspase-8 promotes angiogenesis in endothelial cells through a cell death-independent mechanism involving p38 MAPK activation and VE-cadherin destabilization.

Exploring the extracellular regulation of the tumor angiogenic interaction network using a systems biology model

The paper constructs a systems biology model to explore how extracellular pro- and anti-angiogenic factors regulate tumor angiogenesis, revealing a counterintuitive role for PF4 in enhancing pro-angiogenic signaling.

Positive-feedback defines the timing and robustness of angiogenesis

The paper identifies a positive-feedback mechanism involving Tm4sf18 that accelerates and stabilizes endothelial cell decision-making during angiogenesis.

A VEGF reaction-diffusion mechanism that selects variable densities of endothelial tip cells

The paper proposes and analyzes a VEGF reaction-diffusion mechanism for tip cell selection in angiogenesis, showing variable tip cell densities based on local VEGF production rates.

Vegfa expression is activated through positive and negative transcriptional regulatory networks controlled by the ETS factor Etv6 in vivo

The paper shows Etv6 regulates vegfa expression in Xenopus blood stem cells by both repressing foxo3 and activating klf4, with Klf4 recruiting Etv6 to the vegfa promoter.

Fibroblast growth factor is predicted to dominate MAPK activation by pro-angiogenic factors

This study develops a mathematical model to predict how FGF and VEGF interact to activate MAPK signaling, finding that FGF dominates ERK phosphorylation.

foxc1a and foxc1b differentially regulate angiogenesis from arteries and veins by modulating Vascular Endothelial Growth Factor signalling

The paper investigates the roles of foxc1a and foxc1b in regulating angiogenesis from arteries and veins in zebrafish by modulating VEGF and Dll4/Notch signaling.

Endothelial and non-endothelial responses to estrogen excess during development lead to vascular malformations

This study shows that excess estrogen signaling during development causes vascular malformations in zebrafish by disrupting Hh/Vegf/Notch signaling and promoting aberrant endothelial cell behavior.

The impact of tumor receptor heterogeneity on the response to anti-angiogenic cancer treatment

This study constructs a systems biology model to investigate how tumor receptor heterogeneity affects responses to combination anti-angiogenic therapy in cancer patients.