Angiogenesis and VEGF in Cancer

Endomucin knockout leads to delayed retinal vascular development and reduced ocular pathological neovascularization

This study shows that Endomucin deficiency delays retinal vascular development and reduces pathological neovascularization in mouse models.

Endothelial cell dysfunction and retinal arteriolar narrowing in young adults with elevated blood pressure

This study links endothelial cell dysfunction with retinal arteriolar narrowing in young adults with elevated blood pressure, identifying GRB2 as a potential molecular link.

Endothelial Zmiz1 modulates physiological and pathophysiological angiogenesis during retinal development

This study shows that Zmiz1 is essential for both normal and abnormal angiogenesis in the retina, affecting vascular development and regression in mice.

Endothelial cells signaling and patterning under hypoxia: a mechanistic integrative computational model including the Notch-Dll4 pathway

The paper develops a computational model of endothelial cell signaling under hypoxia, showing differences in patterning pathways and the role of Notch signaling in vascular permeability.

Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells

The paper quantifies trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in HUVECs, showing differences in trafficking rates and surface localization compared to non-human endothelial cells.

Impaired glycolysis in aged endothelial cells is associated with reduced neovascularisation upon tissue ischemia

This study identifies impaired glycolysis in aged endothelial cells as a factor limiting neovascularization during tissue ischemia.

Angiogenic Signaling Counteracts Shear Stress-driven Arterial Patterning.

This study shows VEGF inhibits arterial specification in capillaries by suppressing Sox17, preventing premature arterialization driven by shear stress.

SH2 domain protein E (SHE) and ABL signaling regulate blood vessel size

This study shows that SHE and ABL signaling regulate vascular lumen size in zebrafish and human endothelial cells by modulating claudin expression and cell proliferation.

Pial collaterals develop through mosaic colonization of capillaries by arterial and microvascular endothelial cells

This study identifies a novel mechanism for pial collateral development in embryos and ischemic remodeling in mice, showing distinct roles of arterial and microvascular endothelial cells.

A novel inducible von Willebrand Factor Cre Recombinase mouse strain to study microvascular endothelial cell-specific biological processes in vivo.

This paper develops a Tamoxifen-inducible vWF Cre recombinase mouse strain to study microvascular endothelial cell-specific gene function in vivo.

Endothelial TIE1 restricts angiogenic sprouting to coordinate vein assembly in synergy with its homologue TIE2

This study investigates the role of TIE1 and its interaction with TIE2 in venous development, finding that TIE1 restricts angiogenic sprouting to coordinate vein formation.

Reconstructing stochastic cell population trajectories reveals regulators and heterogeneity of endothelial flow-migration coupling driving vascular remodelling

The paper develops a computational model to analyze EC migration during vascular remodelling, finding that directional migration is driven by dual force fields and mediated by Cdc42 with cell population heterogeneity.

Inhibition of proprotein convertase subtilisin-like kexin type 9 (PCSK9) potentiates anti-angiogenic therapy in colorectal cancer liver metastases

This study shows that PCSK9 inhibition enhances anti-angiogenic therapy effectiveness in colorectal cancer liver metastases with vessel co-option.

Mechanisms of vascular maturation and maintenance captured by longitudinal imaging of live mouse skin

This study uses longitudinal imaging to show how vascular maturation and maintenance occur in live mouse skin through vessel regression, EC rearrangement, and VEGFR2 signaling.

DCBLD1 modulates angiogenesis by regulating of the VEGFR-2 endocytosis in endothelial cells

This study shows DCBLD1 regulates VEGFR-2 endocytosis in endothelial cells, promoting angiogenesis and suggesting it as a therapeutic target for ischemic cardiovascular diseases.

Regulation of Aortic Morphogenesis and VE-Cadherin Dynamics by VEGF

This study investigates VEGF's role in dorsal aorta formation and VE-Cadherin dynamics in chick embryos, showing VEGF's necessity for growth, migration, and adhesion regulation.

Identification of Kinases Activated by Multiple Pro-Angiogenic Growth Factors

The paper identifies kinases critical for endothelial cell proliferation across multiple pro-angiogenic growth factors using a quantitative assay and kinome regression.

Lysine as a potential low molecular weight angiogen: its clinical, experimental and in-silico validation- A brief study

This study investigates lysine as a low molecular weight angiogen, showing its angiogenic properties in ischemic tissues and molecular interactions with VEGF and VEGFR through clinical, experimental, and in-silico methods.

Retinoic acid signaling in mouse retina endothelial cells is required for early angiogenic growth

This study shows that retinoic acid signaling in endothelial cells is critical for early retinal angiogenesis, but the vasculature can recover by P15.

VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome

This study identifies Vegfr3 as a regulator of brain vessel branching and filopodia formation in a Tbx1 mutant mouse model of 22q11.2 deletion syndrome.

Rab35 Governs Apicobasal Polarity Through Regulation of Actin Dynamics During Sprouting Angiogenesis

This study identifies Rab35's role in regulating actin dynamics to establish apicobasal polarity during sprouting angiogenesis.

Mural cell SRF controls pericyte migration, vessel patterning and blood flow

This study investigates the role of SRF in mural cells, showing its importance in pericyte migration, vessel patterning, and blood flow during development and disease.

Identification of key molecules and biological processes in TCF21 treated tumor pericytes

The paper analyzes RNA-seq data to identify key biological processes and signaling pathways in TCF21-overexpressed tumor pericytes, highlighting MAPK and complement/coagulation pathways and several interacting molecules.

N-VEGF, the autoregulatory arm of VEGF-A

This study identifies N-VEGF as an autoregulatory component of VEGF-A that promotes hypoxia-induced gene expression and cell survival.

Naturally occurring combinations of receptors from single cell transcriptomics in endothelial cells

The paper identifies naturally occurring receptor combinations in endothelial cells using single-cell data and introduces a software tool to analyze them, showing evolutionary conservation and relevance to angiogenesis.

Chemical inhibition of prolyl hydroxylases impairs angiogenic competence of human vascular endothelium through metabolic reprogramming

This study shows that inhibiting prolyl hydroxylases with DMOG impairs angiogenic competence of human vascular endothelial cells through metabolic reprogramming.

Distinct Vegfa isoforms control endothelial cell proliferation through PI3 kinase signalling mediated regulation of cdkn1a/p21

This study shows that Vegfa isoforms differentially regulate endothelial cell proliferation via PI3K signaling, independent of MAPK (ERK) activation in zebrafish.

Svep1 stabilizes developmental vascular anastomosis in reduced flow conditions.

This study identifies Svep1 as a factor that stabilizes vascular anastomosis in zebrafish embryos under reduced flow conditions.

Neovascularization and the recruitment of CD31+ cells from the bone marrow are unique under regenerative but not wound repair conditions

This study shows endostatin inhibits epimorphic regeneration in mice by blocking bone marrow-derived CD31+ endothelial precursor recruitment, unlike its effect on wound repair.

Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability

This study shows that inhibiting STAT3 reduces VEGF-induced vascular permeability in zebrafish, mice, and human endothelium, suggesting a therapeutic target for diseases involving vascular leakage.