Ion channel regulation and function

Predicting the functional effects of voltage-gated potassium channel missense variants with multi-task learning

This paper develops a multi-task learning model to predict the functional effects of voltage-gated potassium channel variants, achieving improved accuracy over standard methods.

Structural Basis for pH-Gating of the K+ Channel TWIK1 at the Selectivity Filter

This study presents cryo-EM structures of TWIK1 at different pH levels, revealing how protonation of an extracellular histidine triggers conformational changes that gate the K+ channel.

BK channel properties correlate with neurobehavioral severity in three KCNMA1-linked channelopathy mouse models

The paper evaluates three KCNMA1 variants in mice to correlate BK channel properties with neurobehavioral severity in PNKD3.

Nanometer-Scale Imaging of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels

This study develops optical imaging methods to analyze subcellular localization and dynamics of voltage-gated sodium channels in neurons, revealing developmental regulation and a novel trafficking pathway.

Opposing neural signals of CaV1-encoded peptides are tuned by C-terminus mediated inhibition

The paper identifies opposing transcription signals mediated by CaV1-encoded DCT peptides and shows they are regulated by C-terminus mediated inhibition.

A lysine residue from an extracellular turret switches the ion preference in a Cav3 T-Type channel

The paper shows that a lysine residue in a novel extracellular loop of T-type Cav3 channels determines ion preference by altering the interaction with a nearby aspartate residue.

Calcium-activated big conductance (BK) potassium channels traffic through nuclear envelopes into kinocilia in skate electrosensory cells

The paper identifies a bipartite nuclear localization signal in skate BK channels that regulates their trafficking into nuclei and kinocilia.

Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse

This study shows that Kv3.3 subunits regulate presynaptic action potential waveform and neurotransmitter release at the calyx of Held synapse, affecting high-frequency transmission.

Bayesian inference of kinetic schemes for ion channels by Kalman filtering

This paper develops a Bayesian filter with Kalman filtering to infer kinetic schemes for ion channels, showing improved accuracy and uncertainty quantification compared to classical methods.

A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels

This study identifies A-type FHFs as mediators of resurgent currents in TTX-resistant sodium channels, with FHF4A being critical for Nav1.8 and Nav1.9 channels, and shows its role in reducing neuronal excitability in nociceptive neurons.

Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice

This paper investigates the effects of the SCN2A p.K1422E variant in mice, showing mixed functional and behavioral impacts on neurons and neurodevelopmental phenotypes.

A Leak K+ Channel TWK-40 Regulates Rhythmic Motor Program in C. elegans

This study identifies TWK-40, a K2P channel, as essential for regulating rhythmic motor activity in C. elegans by modulating DVB neuron function and Ca2+ oscillations.

Inhibiting presynaptic calcium channel mobility in the auditory cortex suppresses synchronized input processing

The paper investigates how inhibiting presynaptic calcium channel mobility in the auditory cortex affects synchronized input processing and reveals its role in adjusting network activity across synaptic input strengths.

Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons

The paper investigates how long-term inactivation of NaV1.6 sodium channels contributes to adaptation in CA1 pyramidal neurons through a combined experimental and computational approach.

Minimal requirements for a neuron to co-regulate many properties and the implications for ion channel correlations and robustness

The paper shows that neurons can co-regulate multiple properties only if the number of adjustable ion channels exceeds the number of regulated properties, and that ion channel correlations arise when solution space dimensionality is low.

Shank promotes action potential repolarization by recruiting BK channels to calcium nanodomains

KCNQ channels enable reliable presynaptic spiking and synaptic transmission at high-frequency

The paper shows that KCNQ channels help maintain stable presynaptic action potential waveforms during high-frequency firing, supporting reliable synaptic transmission in rat calyx of Held nerve terminals.

Kinetic and thermodynamic modeling of a voltage-gated sodium channel

The paper models the temperature dependence of voltage-gated sodium channel kinetics using experimental data from rat neurons, showing differences in activation and inactivation temperature sensitivity and providing a temperature-spanning model for action potential generation.

Cannabidiol activates neuronal Kv7 channels

This study identifies CBD's activation of Kv7 channels as a mechanism for its antiepileptic effects.

Genesis of bursting activity: Role of inhibitory constraints on persistent Na+ currents

The paper investigates how inhibitory currents constrain plateau potentials in neurons by comparing three Aplysia neurons with different bursting behaviors.

High-throughput Evaluation of Epilepsy-associated KCNQ2 Variants Reveals Functional and Pharmacological Heterogeneity

This study evaluates 79 KCNQ2 variants using automated patch clamp recording, revealing functional and pharmacological heterogeneity and genotype-dependent retigabine responses.

A different mechanism of C-type inactivation in the Kv-like KcsA mutant E71V

This study investigates the C-type inactivation mechanism in a Kv-like KcsA mutant, finding that the E71V mutation leads to a different structural conformation compared to wild-type KcsA.

Intrinsic Mechanisms in the Gating of Resurgent Na+ Currents

The paper investigates the gating mechanisms of resurgent Na+ currents in mouse cerebellar Purkinje neurons using voltage-clamp recordings and a novel computational model.

Single calcium channel nanodomains drive presynaptic calcium entry at individual lamprey reticulospinal presynaptic terminals

The paper analyzes Ca2+ channel activity at lamprey reticulospinal synapses, showing a small number of channels trigger neurotransmitter release.

Deletion of the voltage-gated calcium channel, CaV1.3, causes deficits in motor performance and associative learning

This study shows that CaV1.3 knockout mice have motor learning deficits and impaired gait adaptation but normal anxiety, depression, and social behaviors.

The voltage-gated Cav Ca2+ channel subunit α2δ-4 is required for locomotor behavior and sensorimotor gating in mice

This study investigates the role of the 2{delta}-4 subunit of Cav Ca2+ channels in mice, finding behavioral impairments in motor function and sensorimotor gating.

Kv3 channels contribute to the excitability of sub-populations of spinal cord neurons in lamina VII

The paper identifies four neuronal types in spinal cord lamina VII, showing Kv3 channels are critical for fast firing in interneurons and synaptic inhibition of parasympathetic preganglionic neurons.

R-type voltage-gated Ca2+ channels mediate A-type K+ current regulation of synaptic input in hippocampal dendrites

This study identifies Cav2.3 as a regulator of Kv4.2-mediated K+ current in hippocampal neurons, showing its role in synaptic input regulation and dendritic excitability.

BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy

This study investigates the functional effects of a de novo KCNMA1 G375R mutation in BK channels by analyzing five subunit combinations, revealing gain-of-function and loss-of-function phenotypes.

Membrane voltage fluctuations in human breast cancer cells

This study characterizes membrane voltage fluctuations in human breast cancer and non-cancerous cells, identifying distinct dynamic patterns linked to cellular transformation.