Tendon Structure and Treatment

Unravelling the distinct phenotype and mechanosensitive properties of different tendon cell populations.

The paper identifies and characterizes a new tendon cell population in the interfascicular matrix, showing its mechanosensitive properties and potential for therapeutic applications.

Engineering a Biomimetic Multiphasic Suture Anchor System for Enhanced Rotator Cuff Enthesis Regeneration

This paper develops a biomimetic scaffold system to enhance rotator cuff enthesis regeneration by replicating native tissue properties and integrating with conventional suture anchors.

Aged Tendons Have Impaired Mechanosensitivity and Lower Thresholds for Injury under Dynamic Compression

Primary cilia regulate mechanical adaptation of tendon and enthesis via hedgehog signaling

The paper investigates how primary cilia and hedgehog signaling mediate mechanical adaptation in tendon and enthesis under altered loading conditions using scRNA-seq and mouse models.

Regulators of ECM Structure Enable Functional Adaptation to Tensile Loading in Tendon Explants

This study investigates how mechanical strain affects tendon ECM remodeling, finding that increased strain promotes anabolic remodeling via TGF-β and IL-6 signaling, while decreased strain leads to catabolic changes.

The developing tendon and enthesis are hypoxic and rely on hypoxia-inducible factor 1a (Hif1a) during postnatal development

This study shows that the postnatal tendon enthesis remains hypoxic and requires Hif1a for cell survival, ECM organization, and structural integrity.

Preventing peritendinous adhesions using lubricious supramolecular hydrogels

This paper develops lubricious supramolecular hydrogels to prevent peritendinous adhesions, showing improved recovery and safety in preclinical models.

Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomics

This study uses spatial and single-cell transcriptomics to map cellular changes in human tendons across development and aging, identifying lineage-specific targets for therapeutic repair.

Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells

This study identifies CD55 and CD248 as novel surface markers for tendon stem/progenitor cells using single-cell and single-nucleus sequencing in mouse Achilles tendon.

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment

Mechanical overload activates hypoxia-inducible factor 1-alpha (HIF1a) in tenocytes to drive tendinopathy independently of VEGFA-mediated vascular ingrowth, and tenocyte Hif1a deletion prevents overload-induced tendon degeneration in mice.

Achilles tendons of MRL/MpJ mice show scar-mediated healing after tenotomy

This study compares tendon healing in MRL/MpJ and C57BL/6J mice after Achilles tenotomy, finding scar formation in MRL/MpJ mice and differences in ossification and signaling pathways.

Dynamic transcriptional and epigenetic changes define postnatal tendon growth

The paper identifies transcriptional and epigenetic changes during postnatal tendon growth and highlights Yap1's role in ECM maturation.

Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit

The paper identifies spatially distinct fibroblast and myonuclei subtypes in human muscle-tendon units that respond to mechanical loading by remodeling the extracellular matrix.

Atelocollagen exhibits superior performance compared to growth factors in upregulating proteins associated with tendon healing

This study compares atelocollagen and growth factors in upregulating tendon healing markers in myoblasts, finding AC more effective in enhancing protein expression and cell proliferation.

In vivo characterization of Achilles subtendon function and morphology within the tendon cross section and along the free tendon

This study develops a method to quantify subtendon sliding in the Achilles tendon using ultrasound and electrical stimulation, finding differential displacement patterns based on stimulated muscle.

Estrogen and progesterone exhibit distinct yet coordinated roles in the regulation of tendon extracellular matrix remodeling

This study investigates sex differences and the roles of estrogen and progesterone in tendon extracellular matrix remodeling using an explant model of mouse tendons.

Mechanical Force Works as a Biological Cue in Postnatal Murine Tendon Development

This study examines mechanical forces during murine tendon development, finding that increased movement correlates with upregulation of Scx and Tnmd.

Coordination of Glucose and Glutamine Metabolism in Tendon is Lost in Aging

This study investigates how glucose and glutamine metabolism changes with aging in tendon tissue and its impact on extracellular matrix remodeling.

mTORC1 and STAT3 signalings are indispensable for in vitro TGFβ1-dependent Three-Dimensional (3D) tendon construct.

This study shows that mTORC1 and STAT3 signaling are essential for TGFβ1-induced 3D tendon construct formation in vitro.

Human adipose stromal cells differentiate towards a tendon phenotype with adapted visco-elastic properties in a 3D-culture system

This study shows that human adipose stromal cells cultured in a minimal 3D system develop a tendon-like phenotype with altered mechanical properties over time.

Understanding the structure and mechanics of the sheep calcaneal enthesis: a relevant animal model for tissue engineering applications

This paper investigates the structure and mechanics of the sheep calcaneal enthesis to inform scaffold design for tissue engineering.

Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution

This study uses single-nucleus RNA sequencing to analyze early cellular changes in human quadriceps tendons after rupture, identifying key cell types and pathways involved in the injury response.

Transcriptome profiling of tendon fibroblasts at the onset of embryonic muscle contraction reveals novel force-responsive genes

The paper identifies force-responsive genes in zebrafish tendon fibroblasts during embryonic muscle contraction using bulk RNA sequencing.

Functional Changes to Achilles Tendon and Enthesis in a Mouse Model of an Adolescent Masculine Gender-Affirming Hormone Treatment

This study examines how puberty suppression and testosterone affect Achilles tendon and enthesis properties in a mouse model of transmasculine gender-affirming hormone therapy, finding improved load capacity and increased cell density with GnRHa treatment.

Tendon Inversion Improves Tendon-to-Bone Healing in a Rat Bicep Tenodesis Model

This study shows that tendon inversion improves bone tunnel healing in rats by disrupting the epitendinous surface and enhancing collagen alignment and tensile strength.

Muscle Contraction is Essential for Tendon Healing and Muscle Function Recovery after Achilles Tendon Rupture and Surgical Repair

This study shows that electrical muscle stimulation improves tendon healing and muscle recovery after Achilles tendon rupture, while static stretching has no additional benefit.

Actin Polymerization Status Regulates Tendon Homeostasis through Myocardin-Related Transcription Factor-A

This study shows that actin polymerization status regulates tenocyte homeostasis via MRTF, affecting genes like Type I Collagen and Tenascin C.

Embryo movement is required for limb tendon maturation

The paper shows that embryo movement is essential for tendon maturation in chick embryos, with YAP signaling and collagen alignment responding to mechanical cues.

Pharmacological Antagonism of Ccr2+ Cell Recruitment to Facilitate Regenerative Tendon Healing

This study shows that temporarily blocking Ccr2+ cell recruitment during the late inflammatory/early proliferative phase improves tendon healing mechanics, while blocking during the acute phase has no effect.

Using dynamic ultrasound to assess Achilles tendon mechanics during running: the effect on running pattern and muscle-tendon junction tracking

This study assesses the impact of dynamic ultrasound on running patterns and muscle-tendon junction tracking during running, finding minimal effects on running and acceptable reliability for tendon strain measurement.