Obsessive-Compulsive Spectrum Disorders

Compulsive coping behaviour, developed predominantly by sign-trackers, is exacerbated by chronic atomoxetine

This study shows that sign-tracking rats develop compulsive drinking behaviors, which are worsened by chronic atomoxetine, suggesting a role for noradrenergic mechanisms in compulsive coping.

Genomic Analysis of Trichotillomania

This study conducts the first genome-wide association analysis of trichotillomania and finds no significant common variants but detects higher polygenic risk and copy number variants associated with neuropsychiatric disorders.

Frontostriatal salience network expands as executive networks contract in Obsessive-Compulsive Disorder

This study identifies a twofold expansion of the salience network and contraction of the frontoparietal network in OCD, linked to symptom severity and dynamic connectivity changes over time.

Individual differences in probabilistic learning and updating predictive representations in individuals with obsessive-compulsive tendencies

The paper investigates individual differences in implicit probabilistic learning and predictive representation updating in people with OC tendencies using two online experiments.

Premorbid Characteristics of the SAPAP3-Mouse Model of Obsessive-Compulsive Disorder: Behavior, Neuroplasticity, and Psilocybin Treatment

This study examines anxiety-like behaviors and synaptic plasticity in juvenile SAPAP3-KO mice before OCD-like grooming emerges, finding no psilocybin treatment effect and age-dependent synaptic changes.

Synaptic editing of frontostriatal circuitry prevents excessive grooming in SAPAP3-deficient mice

The paper edits a specific class of chemical synapses in a genetic OCD mouse model to prevent excessive grooming behavior.

Cerebellin-2 neurons in the parafascicular thalamic nucleus regulate self-grooming behavior

This study identifies Cbln2+ neurons in the parafascicular thalamic nucleus as regulators of self-grooming behavior, showing bidirectional control and potential for non-invasive OCD treatment.

Continuous Neural Correlates of Imbalanced Reinforcement Learning in Obsessive-Compulsive Disorder and Healthy Individuals

The paper identifies a neural network with increased functional connectivity in OCD patients and a subgroup of healthy individuals with imbalanced reinforcement learning.

Uncovering the Neural Correlates of the Urge-to-Blink: A Study Utilising Subjective Urge Ratings and Paradigm Free Mapping

This study identifies brain regions involved in urge-to-blink using multi-echo fMRI and a timing-free approach in healthy volunteers.

Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder

This study identifies 30 genome-wide significant loci for obsessive-compulsive disorder (OCD) using a large GWAS, linking risk to specific brain cell types and shared genetic risk with other psychiatric and non-psychiatric traits.

Investigating neurometabolite changes in response to median nerve stimulation

This study investigates neurometabolite changes during median nerve stimulation using fMRS, finding no significant differences between rhythmic and arrhythmic stimulation but a trend of decreasing glutamate over time.

Immuno-moodulin is Differentially Expressed in T Cells and Plasma in Obsessive-Compulsive Disorder Patients

The paper identifies Imood as an intrinsically disordered protein with distinct expression patterns in T cells and plasma of OCD patients.

Therapeutic DBS for OCD Suppresses the Default Mode Network

This study shows that therapeutic DBS for OCD suppresses BOLD activity in the default mode network compared to non-therapeutic configurations.

The heart rate dynamics and antioxidant capacity under cognitive load in Obsessive-Compulsive disorder

This study examines antioxidant capacity and heart rate dynamics in OCD patients under cognitive load, finding lower antioxidant capacity and distinct HR patterns in subgroups.

Thalamo-frontal connectivity patterns in Tourette Syndrome: Insights from combined intracranial DBS and EEG recordings

This study identifies thalamo-frontal alpha band connectivity patterns in Tourette Syndrome using DBS and EEG, linking reduced connectivity to tic severity and pre-tic dynamics.

De novo variant analysis of childhood-onset obsessive-compulsive disorder in the French-Canadian population

This study identifies de novo variants in childhood-onset OCD in a French-Canadian cohort, finding overlaps with related disorders and suggesting biological mechanisms.

Rescuing behavioral flexibility in a mouse model for OCD by enhancing reward-cue salience

This study investigates behavioral flexibility in OCD using SAPAP3 knockout mice, finding that enhancing reward-cue salience improves reversal learning by restoring sign-tracking behavior.

Hyperactivity of indirect pathway-projecting spiny projection neurons drives compulsive behavior

The paper identifies indirect pathway-projecting spiny projection neurons as a driver of compulsive behavior in a mouse model and shows that reducing their activity alleviates compulsive grooming.

Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice

The paper generates mouse models with human mutations in TD genes, showing sensorimotor and reward learning phenotypes, dopamine changes, and sex-specific effects.

Genome-wide association study identifies new loci associated with OCD

This study conducts a large-scale GWAS of OCD, identifying 15 new genome-wide significant loci and linking OCD to multiple cortical regions and cell types.

Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome

This study uses single-cell transcriptomics to show reduced interneurons and microglia activation in TS basal ganglia, linking gene expression changes to impaired striatal function.

Sapap3 knockout mice show threat bias under conflict during platform mediated avoidance task: implications for obsessive compulsive disorder

This study examines Sapap3 knockout mice in a platform mediated avoidance task, finding heightened threat bias and altered avoidance behavior compared to controls, suggesting mOFC dysfunction in OCD-related mechanisms.

Tic-related behaviors in Celsr3 mutant mice are contributed by alterations of striatal D3 dopamine receptors

The paper investigates how Celsr3 mutations affect tic-like behaviors in mice by examining striatal dopamine receptor alterations.

Increased error rate and delayed response to negative emotional stimuli in antisaccade task in obsessive-compulsive disorder

This study examines eye movement patterns in OCD patients and healthy controls during an antisaccade task with emotional stimuli, finding increased errors and delayed responses to negative stimuli in OCD.

Opponent Learning with Different Representations in the Cortico-Basal Ganglia Pathways Can Develop Obsession-Compulsion Cycle

This paper develops a computational model of cortico-basal ganglia pathways with dual systems learning from positive and negative prediction errors, showing how opponent learning can lead to an obsession-compulsion cycle in OCD.

Obsessive-Compulsive Disorder (OCD) is Associated with Increased Electroencephalographic (EEG) Delta and Theta Oscillatory Power but Reduced Delta Connectivity

This study finds increased delta and theta oscillatory power in OCD patients compared to controls but no significant differences in connectivity measures.

Obsessive-Compulsive Disorder (OCD) is Associated with Increased Engagement of Frontal Brain Regions Across Multiple Event Related Potentials

This study examines ERP differences in OCD patients compared to healthy controls, finding altered frontal brain activity across multiple tasks but no link to symptom severity.

Hippocampal and amygdala subfield volumes in obsessive-compulsive disorder differ according to medication status.

The paper examines hippocampal and amygdala subfield volumes in OCD patients and healthy controls, finding differences based on medication status.

Immp2l knockdown increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a mouse model of Tourette syndrome and autism spectrum disorder

This study investigates the effects of Immp2l knockdown in a mouse model of ASD and GTS, finding no impact on goal-directed learning or neuron density but increased stimulus-driven behaviour.

Spinophilin limits metabotropic glutamate receptor 5 scaffolding to the postsynaptic density and cell type-specifically mediates excessive grooming

The paper investigates the role of spinophilin in mediating mGluR5-dependent repetitive motor dysfunction in striatal neurons, showing subtype-specific effects on grooming behavior and synaptic plasticity.