Neuroinflammation and Neurodegeneration Mechanisms

The paper shows that developmental microglia in zebrafish die after becoming phagocytic, leading to a cycle of debris production and cannibalism that shortens their lifespan.

The paper examines how age and sex influence gene expression in human monocyte subtypes related to neuroinflammation and regeneration, identifying age- and sex-dependent gene changes.

The paper compares proteomic profiles of human and mouse microglia from different sources, revealing significant differences between in vitro and ex vivo cultures.

This study shows brain-resident memory T cells (TRM) can rapidly remodel the CNS immune landscape through activation of multiple immune cells, and PD-1 inhibits granzyme B but not alarm responses.

The paper studies repopulated microglia in young and old mice using scRNA-seq and other methods, finding they originate from progenitors, reconstitute functional clusters, and show increased inflammation and distinct morphology in aging.

This study investigates how an obesogenic diet and psychosocial stress during adolescence affect brain health, revealing synergistic impacts on neuroinflammation, gut microbiota, and gene methylation.

This study shows that AIBP regulates TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease, reducing neuroinflammation and neurodegeneration.

This study shows that inhibiting ATGL in microglia reduces LPS-induced inflammation and sickness behavior in mice.

This study shows that repeated LPS exposure induces training and tolerance in microglial responses across brain regions, with distinct gene expression patterns and morphological changes.

This study examines sex-specific hypothalamic inflammation in mice fed a high-fat and high-sucrose diet and finds partial recovery after diet normalization.

This study uses single-cell RNA sequencing to analyze microglia and macrophages in rhesus macaques during acute SIV infection, revealing changes in cell clusters and gene expression linked to inflammation and neurodegeneration.

The paper investigates microglial interactions with cerebral vasculature using electron microscopy data, finding that 20% of microglia form direct contacts through gaps between astrocyte endfeet.

This study shows IRF3 regulates neuroinflammatory responses and Alzheimer's disease-related gene expression through its effects on microglia and myeloid cells.

The paper investigates how IL-6 exposure affects hiPSC-derived microglia-neural progenitor co-cultures, finding minimal transcriptional response in NPCs despite MGLs secreting IL-6R.

This study shows that adenosine triggers early astrocyte reactivity in sepsis, leading to microglial activation and SAE pathogenesis.

This study identifies aberrant astrocytic calcium signaling in MS models as a contributor to synaptic plasticity impairment and gray matter pathology.

The paper introduces an organelle phenotyping approach using live-cell microscopy to identify C1q as a regulator of microglial function, showing its role in fatty acid storage and mitochondrial membrane potential.

The paper analyzes Ca2+ signaling in human microglia and finds differences in signal properties across morphotypes.

This study uses single-cell RNA sequencing to show SCF+G-CSF treatment modulates microglia and myeloid cells in aged APP/PS1 mice, enhancing immune responses and Aβ clearance.

This study investigates how influenza A virus infection during pregnancy affects maternal intestinal immunity and fetal brain development, finding dose-dependent effects without increased IL-17 signaling.

The paper develops an open-source pipeline to characterize microglia morphology at single-cell resolution using ImageJ and R, identifying distinct morphological states across brain regions and conditions.

The paper identifies molecular signatures of HERV-W ENV protein effects on microglial and astroglial cells compared to LPS stimulation, linking them to neuroinflammatory processes.

This paper introduces a constitutively active microglia-specific Cre line, Fcrls-2A-Cre, with high recombination efficiency and specificity, suitable for studies where tamoxifen is not feasible.

The paper investigates how microglia remove dying oligodendrocytes, finding that CX3CR1 mediates cell engagement while MERTK is not required for clearance.

The paper identifies Kv1.3 potassium channel interactors in microglia using proximity labeling proteomics, revealing domain-specific interactions with immune signaling proteins during inflammation.

This paper uses multi-scale molecular dynamics simulations to study the TREM2/DAP12 transmembrane domain complex formation and its role in Alzheimer's disease.

This study identifies microglia as the primary source of TGF-β1 ligand in the adult mouse brain, showing its role in maintaining microglial homeostasis and cognitive function through an autocrine mechanism.

This study shows that type I interferon signaling in microglia contributes to neuroinflammation and aging in the mouse brain.

This study shows methamphetamine induces long-term transcriptional and morphological changes in microglia that contribute to drug-seeking behavior and may inform treatment strategies for methamphetamine use disorder.

The paper investigates how primary neurons respond to metabolites linked to type 2 diabetes and Alzheimer's disease, identifying differential secretion of MCP-1 and IL-9.