Axon Guidance and Neuronal Signaling

A critical developmental interval of coupling axon branching to synaptic degradation during neural circuit formation

The paper identifies two temporally distinct roles of EGFR in coupling axonal branching to synaptic stabilization during Drosophila visual system development.

Mllt11 regulates the migration and neurite outgrowth of cortical projection neurons during development

This study identifies Mllt11's role in regulating migration and neurite outgrowth of cortical projection neurons during brain development.

Affinity Requirements For Control Of Synaptic Targeting And Neuronal Cell Survival By Heterophilic IgSF Cell Adhesion Molecules

The paper investigates how varying affinities of CAM interactions affect synaptic targeting and neuronal survival in Drosophila, finding different affinity requirements for these processes.

Sticks and Stones, a conserved cell surface ligand for the Type IIa RPTP Lar, regulates neural circuit wiring in Drosophila

This paper identifies Sticks and Stones (Sns) as a conserved ligand for the Drosophila Lar RPTP, showing its role in neural circuit wiring through cis and trans interactions in multiple developmental contexts.

Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by Neuron Navigator 1

This study shows Nav1 regulates neuritogenesis by promoting growth cone macropinocytosis and actin dynamics, linking it to neurotrophin signaling and neural development.

Reanalysis of double EphA3 knockin maps in mouse suggests that stochasticity in topographic map formation acts within the retinal cell population rather than between competing mechanisms at the colliculus

The paper reanalyzes EphA3 knockin mouse data to show stochasticity in retinotopic map formation arises from retinal variability rather than collicular mechanisms.

The PH/MyTH4/FERMmolecule MAX-1 inhibits UNC-5 activity in regulation of VD growth cone protrusion in Caenorhabditis elegans

The paper investigates how MAX-1 inhibits UNC-5 activity to regulate VD growth cone protrusion in C. elegans, showing MAX-1 mutants have smaller, less protrusive growth cones compared to unc-5 mutants.

PP2A phosphatase regulates cell-type specific cytoskeletal organization to drive dendritic diversification

This study identifies PP2A phosphatase as a regulator of cell-type specific dendritic morphology in Drosophila neurons, with distinct roles in promoting branching in Class IV neurons and restricting arborization in Class I neurons.

Topography of corticopontine projections is controlled by postmitotic expression of the area-mapping gene Nr2f1

The paper shows that Nr2f1 gene expression in postmitotic neurons controls corticopontine topographic mapping, while its expression in progenitor cells affects the ratio of corticopontine to corticospinal fibers.

Dendrites use mechanosensitive channels to proofread ligand-mediated guidance during morphogenesis.

This study shows that mechanosensitive DEG/ENaC channels are essential for dendritic arbor morphogenesis in C. elegans by mediating mechanical feedback during ligand-mediated guidance.

A global timing mechanism regulates cell-type specific wiring programs

The paper shows that the Ecdysone pathway regulates timing of transcription factor expression, which in turn controls cell-type specific wiring programs in fly neurons.

Role of Nrp1 in controlling cortical interhemispheric circuits

This study shows that Nrp1 gradient regulates late postnatal branching and refinement of callosal projections in the somatosensory cortex, determining homotopic and heterotopic connectivity.

In situ cryo-electron tomography reveals local cellular machineries for axon branch development

The paper uses cryo-electron tomography to visualize axon branch development in mouse neurons, revealing localized organelle and cytoskeleton dynamics and local protein synthesis at branches.

Tubulin polyglutamylation patterns are central to axon guidance via selective regulation of microtubule-severing enzymes

The paper shows that tubulin polyglutamylation regulates microtubule-severing enzymes in axon guidance, with TTLL6 and TTLL11 having distinct roles in zebrafish and mammalian neurons.

Atypical TGF-beta Signaling Controls Neuronal Guidance in Caenorhabditis elegans

The paper identifies an atypical TGF-beta signaling pathway in C. elegans that regulates neuronal guidance through SMA-6 and NLR-1 interactions.

Myelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve

The paper investigates the role of Netrin-1 and myelinating Schwann cells in regulating vascularization of the developing mouse sciatic nerve, showing Netrin-1 promotes vascular invasion during embryogenesis while Schwann cells reduce it postnatally.

PFTK1 kinase regulates axogenesis during development via RhoA activation.

This study identifies PFTK1's role in axogenesis by regulating RhoA phosphorylation and activity during CNS development in Drosophila and mice.

Serine 1283 in extracellular matrix glycoprotein Reelin is crucial for Reelin's function in brain development

This study shows that phosphorylation at serine 1283 in Reelin is critical for its function in brain development, as disrupting this site leads to neuronal migration defects and altered Reelin levels.

Differential adhesion regulates neurite placement via a retrograde zippering mechanism

The paper investigates how differential adhesion controls neurite placement in C. elegans brain neuropils through a retrograde zippering mechanism.

Repulsive Guidance Molecule Acts in Axon Branching in Caenorhabditis elegans

This study identifies DRAG-1 as a repulsive guidance molecule involved in axon branching of HSNs in C. elegans, showing its requirement in hypodermal cells and interaction with UNC-40 receptor.

The Drosophila RNA binding protein Nab2 patterns dendritic arbors and axons via the planar cell polarity pathway

This study shows Nab2 regulates dendritic arbors and axon projection through the planar cell polarity pathway in Drosophila.

Molecular and Structural Basis of Olfactory Sensory Neuron Coalescence by Kirrel Receptors

This study presents crystal structures of Kirrel receptors, showing their homodimerization mechanism and its role in axon coalescence into glomeruli in the mouse olfactory system.

Netrins and receptors control Drosophila optic lobe organization and transmedullary neuron axon targeting

The paper shows that Notch-dependent fate choice in Drosophila medulla neurons regulates Netrin expression, which controls axon guidance and neuropil organization in the optic lobe.

Systematic expression profiling of dprs and DIPs reveals cell surface codes in Drosophila larval peripheral neurons

The paper systematically profiles dprs and DIPs expression in Drosophila larval neurons to identify cell surface codes involved in synaptic recognition.

A cell-ECM mechanism for connecting the ipsilateral eye to the brain

The paper identifies a cell-ECM recognition mechanism that directs ipsilateral retinal ganglion cell axons to a specific sublamina of the superior colliculus, enabling eye-specific visual pathways.

Loss of the extracellular matrix protein DIG-1 causes glial fragmentation, dendrite breakage, and dendrite extension defects

This study shows that loss of the ECM protein DIG-1 in C. elegans causes glial fragmentation, dendrite breakage, and dendrite extension defects.

The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges.

The paper identifies Sdk1 as a molecular factor that guides dendritic arborization in retinal ganglion cells to enable edge detection.

Nanoscopic Clustering of Neuroligin-3 and Neuroligin-4X Regulates Growth Cone Organization and Size

This study shows that NLGN3/4X clustering at growth cones promotes neuritogenesis and actin organization in immature human neurons, with ASD-associated variants lacking these effects.

Early construction of the thalamocortical axon pathway requires JNK signaling within the ventral forebrain

This study identifies JNK signaling's non-autonomous role in guiding thalamocortical axon pathfinding during forebrain development.

Time to stop; agent-based modelling of chemoaffinity with competition

This paper introduces an agent-based model of retinotectal axon projection using gradient following and receptor-ligand interactions to replicate experimental results without competition.