B. Kim

Atmospheric plasma jet device for versatile electron microscope grid treatment

This paper introduces a non-thermal atmospheric plasma jet system for treating electron microscope grids, enabling hydrophilic surface modification without vacuum requirements.

Cytoplasmic zinc regulates IL-1β production by monocytes/macrophages via mTORC1-induced glycolysis in rheumatoid arthritis (RA)

This study shows cytoplasmic zinc regulates IL-1β production in monocytes/macrophages through mTORC1-induced glycolysis by inhibiting PP2A.

A novel vascular endothelial growth factor-trap KP-VR2 with enhanced ligand blocking

This study develops KP-VR2, a novel VEGF-Trap that neutralizes VEGF-A, VEGF-B, and PlGF, showing improved antitumor efficacy compared to existing therapies.

Robust integrated intracellular organization of the human iPS cell: where, how much, and how variable

The paper establishes quantitative rules for the locations, amounts, and variation of 25 cellular structures in human iPSCs using high-resolution imaging and analysis.

Two new hybrid zones expand the swordtail hybridization model system

The paper identifies two genetically distinct subpopulations in swordtail fish hybrid zones, suggesting strong assortative mating and limited gene flow.

A 'Cell-Nucleus Segmentation' Script for Non-Invasive Nuclear Dry Mass Measurement

This paper introduces an image analysis script to quantify nuclear dry mass using fluorescent and quantitative phase images, revealing a correlation between nuclear dry mass and filopodia dynamics in cervical epithelial cells.

Third-generation dual-source computed tomography of the abdomen: comparison of radiation dose and image quality of 80kVp and 80/150kVp with tin filter

This study compares 80 kVp and 80/Sn150 kVp CT in oncology patients, finding 80 kVp provides better image quality and lower radiation dose.

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.

Nanotrap(R) particles improve detection of SARS-CoV-2 for pooled sample methods, extraction-free saliva methods, and extraction-free medium methods

This paper introduces a method using Nanotrap(R) particles to improve SARS-CoV-2 detection in pooled samples, saliva, and transport medium by concentrating virus before RNA extraction.

A multiplex CRISPR interference tool for virulence gene interrogation in an intracellular pathogen

This paper develops a multiplex CRISPRi platform in Legionella pneumophila to silence up to ten virulence genes simultaneously, demonstrating its effectiveness in both axenic growth and macrophage infection.

SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells

This study shows that SUMOylation of SAMHD1 at K595 is necessary for its antiviral activity in non-cycling cells, independent of its dNTPase function.

Viral cross-linking and solid-phase purification enables discovery of ribonucleoprotein complexes on incoming RNA virus genomes

The paper introduces VIR-CLASP, a method to identify RNA virus-host protein interactions by cross-linking and solid-phase purification, and demonstrates its application with 4SU-labeled viral genomes.

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells

This study shows that RU.521 inhibits human and mouse cGAS, reducing cGAMP production and cytokine expression in response to dsDNA, without affecting RNA or interferon-induced responses.

Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology

The paper uses machine learning to link drug targets with adverse drug reactions using in vitro pharmacology data and FDA reports, identifying 221 target-ADR associations.

Thymidylate synthase maintains the de-differentiated state of aggressive breast cancers

This study shows that thymidylate synthase promotes de-differentiation in aggressive breast cancers by supporting pyrimidine catabolism and EMT, correlating with poor prognosis.

Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites.

This study shows dihydropyrimidines are cytotoxic metabolites that cause DNA replication stress and DPCs, suggesting DHP inhibition could target solid tumors.

CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1

This study shows that the CBFβ-MYH11 fusion protein inhibits megakaryocyte differentiation by disrupting the GATA2 and KLF1 gene program in inv(16) AML cells.

The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

This study shows that AhR and IFN-gamma activation repress CDK1/2 and cyclins, reducing dNTP levels and inhibiting HIV-1 and HSV-1 replication.

Evaluating Tumor Evolution via Genomic Profiling of Individual Tumor Spheroids in a Malignant Ascites from a Patient with Ovarian Cancer Using a Laser-aided Cell Isolation Technique

The paper uses genomic profiling of tumor spheroids from malignant ascites to evaluate tumor evolution in an ovarian cancer patient, finding genetic differences between primary tumor and spheroids.