C. Wang

O-GlcNAcylation of Keratin 18 coordinates TCA cycle to promote cholangiocarcinoma progression

The paper shows O-GlcNAcylation of Keratin 18 coordinates TCA cycle enzymes to promote cholangiocarcinoma progression by stabilizing K18 and altering metabolite levels.

Enhancing Inter-link Coverage in Cross-Linking Mass Spectrometry through Context-Sensitive Subgrouping and Decoy Fusion

The paper improves inter-link detection in cross-linking mass spectrometry by using a fused database and context-sensitive subgrouping, increasing coverage by 30-75% while maintaining low error rates.

Physiological and metabolic insights into the first cultured anaerobic representative of deep-sea Planctomycetes bacteria

This study cultures a novel deep-sea Planctomycetes strain, characterizes its physiology and metabolism, and reveals nitrogen metabolism reprogramming by chronic bacteriophages.

Breakthrough infection elicits hypermutated IGHV3-53/3-66 public antibodies with broad and potent neutralizing activity against SARS-CoV-2 variants including BQ and XBB lineages

This study identifies hypermutated IGHV3-53/3-66 antibodies from breakthrough infections that broadly neutralize SARS-CoV-2 variants including BQ and XBB.

Proguanil and chlorhexidine augment the antibacterial activities of clarithromycin and rifampicin against Acinetobacter baumannii

This study shows that combining proguanil and chlorhexidine with clarithromycin or rifampicin enhances antibacterial activity against Acinetobacter baumannii in vitro and improves treatment outcomes in mice.

Injectable ventral spinal stimulator evokes programmable and biomimetic hindlimb motion

This paper describes an injectable spinal stimulator that enables precise and programmable hindlimb movement in mice by targeting ventral spinal regions.

Cryo-EM studies of the four E. coli paralogs establish ABCF proteins as master plumbers of the peptidyl-transferase center of the ribosome

This study presents cryo-EM structures of four E. coli ABCF paralogs bound to the ribosome, revealing their role in modulating tRNA geometry and catalytic function at the peptidyl-transferase center.

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

Essential role of the Conserved Oligomeric Golgi complex in Toxoplasma gondii

This study identifies the essential role of the COG complex in Toxoplasma gondii, showing its expanded function in membrane trafficking and unique adaptations in the parasite's secretory system.

SeMOE allows for quantitative glycan perception and exhibits anti-cancer potentiality

SeMOE enables absolute glycan quantification and visualization through selenosugar-based metabolic oligosaccharide engineering, with demonstrated anti-cancer potential.

The D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice

This study shows that the D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice by disrupting nuclear-cytosolic Ca2+ coupling.

OpenABC Enables Flexible, Simplified, and Efficient GPU Accelerated Simulations of Biomolecular Condensates

OpenABC simplifies GPU-accelerated simulations of biomolecular condensates using Python, offering performance comparable to hundreds of CPUs and tools for converting to all-atom structures.

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

Nucleolar structure connects with global nuclear organization

This study shows that disrupting nucleolar structure in HeLa cells affects global nuclear organization, including changes in genomic loci and nuclear bodies, independent of ribosome synthesis inhibition.

Latent transcriptional programs reveal histology-encoded tumor features spanning tissue origins

This paper uses machine learning to identify latent transcriptional programs in squamous cell carcinomas from histology images, linking them to clinically relevant biological processes.

Lactococcus G423 Ameliorates the Growth Performance of Broilers by Modulation of Gut Microbiota- Metabolites

This study shows Lactococcus G423 improves broiler growth and survival by altering gut microbiota and metabolites, while antibiotics negatively affect microbiota.

Structural basis for functional properties of cytochrome c oxidase

This study reveals the structural differences between the oxidized O state and the metastable OH state of cytochrome c oxidase using spectroscopy and crystallography, showing how Y244's protonation state affects proton translocation.

High Resolution Salmonella Subtyping by the MLSTnext Method

The paper introduces a high-resolution Salmonella subtyping method using MLSTnext-NGS, which efficiently identifies serovars and resolves mixed strains in food samples.

Endothelial cell-derived lactate triggers mesenchymal stem cell histone lactylation to attenuate osteoporosis

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

Unfolded Protein Response Factor ATF6 Augments T Helper Cell Responses and Promotes Mixed Granulocytic Airway Inflammation

This study shows ATF6 enhances TH2 and TH17 cell responses and contributes to mixed granulocytic airway inflammation, suggesting ATF6 inhibition as a potential therapy for steroid-resistant asthma.

Pleiotropic Regulatory Locus1 maintains actin microfilament integrity and concomitant cellular homeostasis facilitating root development in Arabidopsis

This study identifies PRL1's role in maintaining actin microfilament integrity and cellular homeostasis, linking actin depolymerization to root developmental defects in Arabidopsis.

PRL1 negatively regulates Rho GTPase-independent and -dependent signaling pathways maintaining actin microfilament dynamic for pavement cell morphogenesis

This study identifies PRL1 as a regulator of actin microfilament dynamics in Arabidopsis pavement cells through both Rho GTPase-dependent and -independent pathways.

CLE11 and CLE10 Suppress Mycorrhizal Colonisation in Tomato

This study identifies SlCLE10 and SlCLE11 as CLE peptides that suppress arbuscular mycorrhizal colonisation in tomato roots, with SlCLE11 acting locally and SlCLE10 showing a minor or redundant role.

Comparison between Canine and Porcine Models of Chronic Deep Venous Thrombosis

This study induces chronic deep venous thrombosis in canine and porcine models and compares their suitability for translational therapeutic research.

A megaprotein brake for aging and insulin-mTOR signaling

This study identifies LPD-3 as a megaprotein that regulates insulin-mTOR signaling and aging in C. elegans by modulating sphingolipid and insulin pathways.

Ferroptosis is determined by chloride ions

This study identifies chloride ions as essential determinants of ferroptosis, showing that extracellular chloride levels influence lipid peroxidation and cell death.

NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype

This study shows that NLRP1 inflammasome promotes senescence and SASP through GSDMD-dependent regulation of p16, p21, p53, and SASP expression.

The Alfin-like transcription factor GmAlfin09 regulates endoplasmic reticulum stress in soybean via a peroxidase GmPRDX6

This study identifies GmAlfin09 as a transcription factor that enhances ER stress resistance in soybean by upregulating GmPRDX6, which reduces ROS levels and maintains ER homeostasis.

Sequential restoring O2 then unloading CO2 is beneficial against reperfusion injury: role of CO2 in metabolism

The paper shows that sequential reperfusion with high CO2 then normal CO2 reduces cardiac ischemic reperfusion injury in rat hearts by altering metabolic pathways.

A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

This study characterizes human glioblastoma organoids using multi-omics analysis and identifies drug targets linked to glycerol lipid reprogramming.