C. Wang

Chiral Graphene Quantum Dots Enhanced Drug Loading into Exosomes

This paper presents a chiral graphene quantum dots platform for efficient drug loading into exosomes, achieving high loading efficiencies for both hydrophobic and hydrophilic drugs.

Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses

This paper identifies PfGCN5 as a key regulator of stress responses in Plasmodium falciparum, showing its role in artemisinin resistance and sensitivity to various stress conditions.

Spin-coupled electron densities of iron-sulfur cluster imaged by in situ serial Laue diffraction

The paper uses in situ serial Laue diffraction to image spin-coupled electron densities in a [4Fe4S] iron-sulfur cluster during light-induced redox reactions.

HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

This study identifies HERC5-catalyzed ISGylation of cGAS as a mechanism that enhances antiviral innate immunity by modulating the cGAS-STING pathway.

Single-cell transcriptional analysis of lamina propria lymphocytes in the jejunum reveals ILC-like cells in pigs

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

Determination of insulin secretion from stem cell-derived islets with liquid chromatography-tandem mass spectrometry

The paper develops a sensitive and selective RPLC-MS/MS method to quantify insulin secretion from islet organoids, overcoming carry-over and sensitivity issues with low-volume samples.

Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

MYSM1 co-activates ERα action via histone and non-histone deubiquitination to confer antiestrogen resistance in breast cancer

This study identifies MYSM1 as an ER co-activator that promotes antiestrogen resistance in breast cancer through histone and non-histone deubiquitination.

The structural basis of itch receptor MRGPRX1 activation

This study reports the cryo-EM structure of MRGPRX1 bound to an agonist, revealing its activation mechanism and guiding the design of specific modulators for itch and pain treatment.

Polyethylene valorization by combined chemical catalysis with bioconversion by plastic-enriched microbial consortia

This paper combines chemical catalysis and microbial consortia to valorize polyethylene deconstruction products into valuable wax esters.

STING-dependent cytosolic DNA sensing pathway drives the progression to leukemia in TET2-mutated HSPCs

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

Inhibiting POLQ-mediated alternative NHEJ enhances CRISPR/Cas9 mediated precise genome editing in CHO cells

This study shows that inhibiting POLQ in CHO cells enhances CRISPR/Cas9-mediated precise genome editing by increasing knock-in efficiency and reducing random integration.

A Host-Harbored Metabolic Susceptibility of Coronavirus Enables Broad-Spectrum Targeting

The paper identifies a host metabolic pathway essential for coronavirus replication and shows that inhibiting it with Propranolol has broad antiviral effects.

Latitude influences stability via stabilizing mechanisms in naturally-assembled forest ecosystems at different spatial grains

The paper examines how latitude affects ecosystem stability in forests across different spatial scales, finding that species asynchrony and stability play key roles, with latitude influencing these mechanisms to counteract species richness effects.

Genome-wide Identification and Expression Profile Analysis of Laccase Family Genes in the Hypsizygus marmoreus

This study identifies 18 laccase genes in Hypsizygus marmoreus, analyzes their genomic distribution, evolution, and expression patterns, and links specific genes to lignin degradation and fruiting body formation.

Peyers Patch B cells undergo cell death via neutrophil-released toxic DNA following sterile tissue injury

The paper shows that sterile tissue injury causes B cell death in Peyers patches via neutrophil-released toxic DNA, leading to tissue shrinkage and reduced secretory IgA.

Oral Feeding of Nanoplastics reduces Brain function of Mice by Inducing Intestinal IL-1β-producing Macrophages

This study shows that oral nanoplastic exposure in mice leads to gut macrophage activation and IL-1β production, which affects brain function by causing microglial activation and cognitive decline.

Microsecond pulse electrical stimulation modulates cell migration

This study introduces microsecond pulse electric field (sPEF) to enhance wound healing by promoting fibroblast migration and ECM alignment, validated in 2D and 3D models and a mouse wound healing assay.

A reversible SRC-relayed COX2-inflammatory program drives therapeutic resistance in BRAF(V600E) colorectal tumors

This study identifies a SRC-relayed COX2-inflammatory program that drives resistance to BRAF/MEK/EGFR therapies in BRAFV600E colorectal tumors and shows that co-targeting COX2 improves therapeutic outcomes.

FGFR1 governs iron metabolism via regulating post-translational modification of IRP2 in prostate cancer cells

This study shows FGFR1 promotes prostate cancer by enhancing iron metabolism through regulation of IRP2 post-translational modification and TFR1 expression.

Manipulating Oxalate Decarboxylase Provides the Basis of Antilithic Therapy by Acting on the Gut Microbiota

The paper identifies Zn2+ as a therapeutic agent for calcium oxalate kidney stones by enhancing oxalate-degrading bacteria and their enzymes in the gut microbiota.

Mechanism of dual pharmacological correction and potentiation of human CFTR

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on single motor unit discharge patterns

This paper introduces a geometric method to quantify neuromodulatory and inhibitory effects on motor unit discharge patterns using metrics like brace height and slopes, validated on simulated and human data.

Highly synchronized cortical circuit dynamics mediate spontaneous pain

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

ATM-Mediated Double-Strand Break Repair Is Required for Meiotic Genome Stability at High Temperature

This study shows ATM is essential for maintaining meiotic genome stability in Arabidopsis at high temperatures, acting through the MRN complex and chromosome axis, independent of RAD51.

PF-D-Trimer, a broadly protective SARS-CoV-2 subunit vaccine: immunogenicity and application

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

Effect and mechanism of black soybean peptides alleviating oxidative damage in the celiac disease cell model

This study investigates how black soybean peptides alleviate oxidative damage caused by alpha gliadin peptide in a celiac disease cell model.

Microbiota-stimulated Interleukin-22 regulates brain neurons and protects against stress-induced anxiety

This study identifies IL-22 as a key immune-to-brain signal that reduces stress-induced anxiety by acting on septal neurons.

Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition

The paper identifies host range determinants of ACE2-using MERS-related coronaviruses by analyzing receptor recognition across mammals.

Acetylation of a fungal effector that translocates host PR1 facilitates virulence

This study identifies acetylation of the fungal effector FolSvp1 as critical for its stability and virulence in tomato plants.