C. Wang

Pan-azole- and multi-fungicide-resistant Aspergillus fumigatus is widespread in the United States

This study identifies pan-azole- and multi-fungicide-resistant Aspergillus fumigatus in agricultural environments across 7 U.S. states.

A novel simian adenovirus vectored COVID-19 vaccine elicits effective mucosal and systemic immunity in mice by intranasal and intramuscular vaccination regimens

This paper evaluates a novel simian adenovirus vectored COVID-19 vaccine, showing that intranasal vaccination induces stronger mucosal immunity while intramuscular vaccination enhances systemic immunity, with combined regimens providing long-term protection.

E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation

This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.

AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection

This study shows LGG metabolites activate ILC3 cells via AhR to produce IL-22, which prevents PEDV infection in piglets by enhancing intestinal cell proliferation and STAT3 signaling.

GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors

This paper shows that activating GABA(A) receptors in lung cancer cells triggers autophagy via GABARAP-Nix interaction, enhancing radiation sensitivity and reducing toxicity in preclinical models.

Middle-infrared Modulation Of Sleep By Cardiometabolic Function

This study shows that middle-infrared radiation improves sleep by enhancing blood circulation and reducing homocysteine and T-cell levels, linking cardiometabolic function to sleep quality.

Staphylococcus aureus skin colonization is mediated by SasG lectin variation

This study identifies SasG-II, a variant of the S. aureus surface protein, which binds to a broader range of ligands, enhancing its ability to colonize skin.

Tau alters global gene expression affecting chromatin in the early stages of Alzheimer's disease

The paper shows that Tau affects global gene expression and chromatin structure in early Alzheimer's disease stages through cellular and transcriptomic analysis.

Pharmacologically inducing regenerative cardiac cells by small molecule drugs

This study shows that a two-drug combination induces regenerative cardiac cells from cardiomyocytes in vitro and in vivo, improving heart function after injury.

The force-sensing GPCR LPHN2 is indispensable for normal auditory function

This study identifies LPHN2 as a force-sensing GPCR critical for auditory function, showing its role in mechanoelectrical transduction and hearing loss when deficient.

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

This study identifies RAD18's role in TMZ resistance and hypermutation in GBM by linking it to TLS and MMR pathways through CRISPR screening and mutation analysis.

Enterocytozoon hepatopenaei Proliferate in Procambarus clarkii: A Warning for Crayfish and Shrimp Aquaculture

This study shows that crayfish (Procambarus clarkii) can harbor and transmit the microsporidian parasite Enterocytozoon hepatopenaei, posing a risk to shrimp farming.

Myofascial Trigger Point (MTrP) Size and Elasticity Properties Can Be Used to Differentiate Active and Latent MTrPs in Lower Back Skeletal Muscle

The paper develops ultrasound-based metrics to differentiate active and latent myofascial trigger points by measuring size, elasticity, and depth.

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss

This study shows doxorubicin causes bone loss via inflammasome activation, leading to pyroptosis and NETosis, and identifies AIM2 and NLRP3 as key mediators.

Conservation of the ancestral function of GTSF1 in transposon silencing in unicellular Paramecium

This study shows that GTSF1 functions as a PIWI cofactor in transposon silencing in the unicellular eukaryote Paramecium, conserving an ancestral role observed in metazoans.

Deep-sea in situ and laboratory proteomics provide insights into the sulfur metabolism of a novel deep-sea bacterium, Pseudodesulfovibrio serpens sp. nov.

This study isolates and characterizes a novel deep-sea sulfate-reducing bacterium, revealing its sulfur metabolism and potential coupling with methane oxidation in deep-sea environments.

Requirement of microtubules for secretion of a micronemal protein CpTSP4 in the invasive stage of the apicomplexan Cryptosporidium parvum

This study identifies CpTSP4, a new micronemal protein in Cryptosporidium parvum, showing its secretion during invasion and dependence on microtubular trafficking and heparin-binding for host interaction.

mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated non-degradative ubiquitination of eIF4A1

The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity

The paper shows that Gb3 lipid on GC B cells enhances antibody affinity and breadth, promoting cross-protective immunity against influenza.

Cardiac disease diagnosis based on GAN in case of missing data

This paper proposes AGAN, a GAN-based method for filling missing data in cardiac disease datasets, improving data quality and downstream classification accuracy.

Quantitative Learning of Cellular Features From Single-cell Transcriptomics Data Facilitates Effective Drug Repurposing

This study introduces SuperFeat, a framework that uses single-cell transcriptomics data to identify drug targets by modeling adverse cellular states, validated in vitro and in vivo.

Picomolar-Level Sensing of Cannabidiol by Metal Nanoparticles Functionalized with Chemically Induced Dimerization Binders

This paper develops a method for detecting cannabidiol (CBD) at picomolar levels using gold nanoparticles functionalized with chemically induced dimerization binders, achieving high sensitivity and specificity in biological samples.

Probucol mitigates high-fat diet-induced cognitive and social impairments through disruption of redox-inflammation association

This study shows probucol reduces high-fat diet-induced cognitive and social impairments in mice without affecting obesity or metabolic homeostasis, by disrupting redox-inflammation links.

Rof is a key regulator of Rho and transcription termination in bacteria

This study reports the cryo-EM structure of the Rho-Rof antitermination complex and shows Rof inhibits Rho-dependent termination, essential for bacterial virulence.

Metabolites with benzene ring from sugarcane leaf play important role in plant-Spodoptera frugiperda interaction

The paper identifies benzene-ring containing metabolites in sugarcane that influence Spodoptera frugiperda behavior and development, with some promoting insect growth and others repelling them.

High-speed 3D DNA PAINT and unsupervised clustering for unlocking 3D DNA origami cryptography

This paper develops a DNA origami cryptography protocol using high-speed 3D DNA-PAINT and unsupervised clustering to enhance encryption key size and information retrieval accuracy.

Harnessing extracellular vesicles for efficient siRNA delivery in vitro and in vivo

This study develops an efficient siRNA delivery system using extracellular vesicles, demonstrating effective gene silencing in vitro and tumor growth inhibition in vivo.

Von Willebrand Factor Synergizes with Tumor-Derived Extracellular Vesicles to Promote Gastric Cancer Metastasis

This study shows that von Willebrand factor (VWF) and gastric cancer-derived extracellular vesicles (gcEVs) work together to promote metastasis by disrupting endothelial integrity and facilitating cancer cell migration.

Defense mechanism of a bacterial retron supramolecular assembly

The paper identifies a phage-encoded DNA methyltransferase as a trigger for the Ec86 retron system and describes its supramolecular assembly and defense mechanism.

Simultaneous LC-MS determination of glucose regulatory peptides secreted by stem cell-derived islet organoids

The paper develops an RPLC-MS/MS method to simultaneously measure insulin, somatostatin-14, and glucagon from stem cell-derived islet organoids on an organ-on-chip platform, showing functional hormone secretion.