F. Yang

Antifungal tolerance and resistance emerge at distinct drug concentrations and rely upon different aneuploid chromosomes

This study identifies that antifungal drug tolerance and resistance in Candida albicans emerge at different drug concentrations and are associated with distinct aneuploid chromosomes.

Pulsed stimulated Brillouin microscopy enables high-sensitivity mechanical imaging of live and fragile biological specimens

This paper introduces pulsed stimulated Brillouin microscopy to improve mechanical imaging of live biological specimens with reduced phototoxicity and enhanced signal-to-background ratio.

Knockdown of mitochondrial atp1 mRNA by a custom-designed pentatricopeptide repeat protein alters F1Fo ATP synthase

This study shows that a custom-designed PPR protein knocks down mitochondrial atp1 mRNA, reducing F1Fo ATP synthase, plant growth, and amino acid metabolism in Arabidopsis.

Structural Insights into Branch Site Proofreading by Human Spliceosome

The paper reports atomic structures of human spliceosome complexes to elucidate PRP5's role in branch site proofreading during pre-mRNA splicing.

Genetic and histological correlation between the musk gland and skin of Chinese forest musk deer

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

"Double-Effect" strategy against Triple-Negative Breast Cancer via a synergistic therapy of Magneto-mechanical Force enhancing NIR-II Hypothermal Ablation

This paper develops a synergistic therapy for triple-negative breast cancer using magneto-mechanical force and NIR-II hypothermal ablation to suppress tumor migration and invasion.

Retrotransposons hijack alt-EJ DNA repair process for mobilization and eccDNA biogenesis

This study shows retrotransposons use the alt-EJ DNA repair pathway to generate eccDNA and achieve mobilization.

Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis

This study shows that ASF1 in Arabidopsis preferentially interacts with the HIRA complex for H3.3-H4 deposition, affecting chromatin structure and gene regulation.

ATF3 Preserves Skeletal Muscle Stem Cell Quiescence by Preventing Precocious Activation

This study identifies ATF3 as a key regulator that preserves skeletal muscle stem cell quiescence by preventing premature activation and maintaining genome stability.

Emerging Evidence for Poxvirus-Mediated Unfolded Protein Response: Lumpy Skin Disease Virus Maintains Self-replication by Activating PERK and IRE1

This study shows that lumpy skin disease virus activates PERK and IRE1 pathways to support its replication, suggesting potential therapeutic targets for poxvirus infections.

Rab7/Retromer-based endolysosomal trafficking facilitates effector secretion and host invasion in rice blast

This study identifies a novel endolysosomal trafficking pathway in Magnaporthe oryzae that facilitates effector secretion and host invasion via Rab7/Retromer/MoSnc1-mediated vesicle transport.

Deeply conserved super-enhancers maintain stem cell pluripotency in placental mammals

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

Phototherapy with physically and molecularly produced light for Alzheimer's disease

This study shows that combining a photolabile Aβ ligand with LED or molecular light can reduce Aβ accumulation in mice, suggesting a new phototherapy approach for Alzheimer's disease.

Knockout of OsSWEET15 impaired rice embryo formation and seed-setting

This study shows that knocking out OsSWEET15 in rice reduces fertility by impairing embryo formation and seed-setting, with similar effects observed in OsSWEET11 mutants.

Single cell profiling of γδ hepatosplenic T-cell lymphoma unravels tumor cell heterogeneity associated with disease progression

This study uses single-cell RNA-seq and TCR sequencing to identify tumor subtypes and cell-cell interactions in HSTCL, revealing disease progression and potential therapeutic targets.

Two distinct binding modes provide the RNA binding protein RbFox with extraordinary sequence specificity

This study identifies two distinct binding modes of RbFox's RNA Recognition Motif that contribute to its high sequence specificity and functional diversity.

Serum Amyloid A promotes Acetaminophen-induced liverinjury by damaging sinusoidal endothelial cell and exacerbating platelet aggregation in liver

This study shows that Serum Amyloid A (SAA) worsens acetaminophen-induced liver injury by damaging sinusoidal endothelial cells and increasing platelet aggregation.

Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32

The paper presents cryo-EM structures of yeast TRAPPII complex in apo and Ypt32-bound states, revealing its assembly mechanism and specific activation of Ypt31/Ypt32.

Fungal auxin is a quorum-based modulator of blast disease severity

This study identifies fungal auxin as a quorum-sensing signal modulating rice blast disease severity through IAA biosynthesis and secretion.

Time Evolution of the Stroke Symptom-Herb Networks Based on TCM Prescriptions

This study constructs and analyzes Stroke Symptom-Herb Networks (SSHNs) from historical TCM prescriptions to reveal their dynamic structure and evolutionary trends over 1700 years.

Screening of cell-virus, cell-cell, gene-gene interactions among kingdoms of life at single cell resolution

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

Diversity of Antibiotic Resistance genes and Transfer Elements-Quantitative Monitoring (DARTE-QM): a method for detection of antimicrobial resistance in environmental samples

DARTE-QM is a method using high-throughput sequencing to detect antibiotic resistance genes in environmental samples, demonstrating efficiency and scalability.

An orthologous gene coevolution network provides insight into eukaryotic cellular and genomic structure and function

The paper constructs an orthologous gene coevolution network from 332 budding yeast species to explore eukaryotic cellular and genomic structure and function, revealing insights into gene connectivity and environmental fitness.

Directional Cell Migration Guided by a Strain Gradient

This study shows that strain gradients can drive directional cell migration in rat embryonic fibroblasts, distinct from durotaxis or haptotaxis.

Sulfation of glycosaminoglycans depends on catalytic activity of a lithium-inhibited phosphatase

This study shows that BPNT2 catalytic activity is essential for GAG sulfation, and lithium inhibits this process, affecting extracellular matrix composition and lithium's therapeutic effects.

Structural insights into the recognition of histone H3Q5 serotonylation by WDR5

This study identifies WDR5 as a reader of H3Q5ser, showing it binds to this modification and promotes transcription in neuroblastoma cells, suggesting a role in tumorigenesis.

Transcription factor-like 5 is a potential DNA/RNA-binding protein essential for maintaining male fertility in mice.Running title: Tcfl5 is haploinsufficient in vivo

This study identifies Tcfl5 as a testis-specific protein essential for male fertility, showing that heterozygous mice are infertile and exhibit abnormalities in spermatids and spermatozoa.

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 variants

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

Lizard feeding enhances Ixodes pacificus vector competency

This study shows that feeding Ixodes pacificus larvae on lizards increases their likelihood of becoming infected with Borrelia burgdorferi compared to feeding on mice, and alters gene regulation.