G. Yang

Regulation of drought tolerance in Arabidopsis involves PLATZ4-mediated transcriptional suppression of PIP2;8

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

Structure insights of the human peroxisomal ABC transporter ALDP

The paper reports the cryo-EM structure of human ALDP, revealing its conformation and potential lipid-binding site, which aids in understanding disease-causing mutations.

How To Extend The Capabilities Of A Commercial Two-Photon Microscope To Perform Super-Resolution Imaging, Wavelength Mixing And Label-Free Microscopy.

This paper describes a hybrid microscope system that extends a commercial two-photon microscope to perform super-resolution imaging, wavelength mixing, and label-free microscopy.

Genome-wide identification and characterization of DNA/RNA differences associated with Fusarium graminearum infection in wheat

This study identifies 187 DNA/RNA differences in 36 wheat genes associated with Fusarium head blight, showing their role in regulating FHB response through structural changes and miRNA interactions.

Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

This paper describes a monoclonal antibody, DZIF-10c, that effectively neutralizes SARS-CoV-2 and its variants when administered intranasally to mice, offering potential for topical treatment.

5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

The Expression of Angiopoietin-1 and -2 in the Osteogenesis of Mesenchymal Stem Cells

This study shows that rat mesenchymal stem cells express Ang1 and Ang2, which are upregulated during osteogenesis in vitro.

Intrinsic cardiac adrenergic cells contribute to septic cardiomyopathy

This study identifies intrinsic cardiac adrenergic cells as contributors to septic cardiomyopathy by releasing norepinephrine that exacerbates cardiac dysfunction through β1-adrenergic receptor activation.

Landscape composition mediates suppression of major pests by natural enemies in conventional cruciferous vegetables

This study shows that increasing semi-natural habitats in conventional cruciferous vegetable fields improves pest suppression by natural enemies, with effects varying by pest type and landscape scale.

SiCEP3, a C-terminally encoded peptides from Setaria italica, promotes ABA import and signaling pathway

This study identifies SiCEP3, a C-terminally encoded peptide from Setaria italica, which promotes ABA import and signaling by inhibiting receptor kinase activity under abiotic stress.

Molecular basis of functional compatibility between ezrin and other actin-membrane associated proteins during cytokinesis

This study investigates how ezrin interacts with actin-membrane proteins during cytokinesis, revealing differential compatibility in their binding sites and functional roles.

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

SARS-CoV-2 infection causes transient olfactory dysfunction in mice

This study shows SARS-CoV-2 infection causes temporary olfactory dysfunction in mice by targeting olfactory epithelium cells and disrupting their structure and function.

Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

Biomarker-guided treatment strategies for ovarian cancer identified from a heterogeneous panel of patient-derived tumor xenografts

This study identifies biomarker-guided treatment strategies for ovarian cancer using patient-derived tumor xenografts, finding that nearly 90% of PDXs responded to at least one targeted therapy.

Restoration of β-globin expression with optimally designed lentiviral vector for β-thalassemia treatment in Chinese patients

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

Forkhead box O1-mediated ubiquitination suppresses RIG-I-mediated antiviral immune responses via its DNA binding domain

The paper withdraws its manuscript due to the need for further experiments to validate conclusions.

Molecularly Targeted Magnetic Resonance Imaging and Spectroscopy

This paper introduces a novel MRI/MRS method that selectively images specific metabolites by using nuclear spin singlet states, demonstrating molecular selectivity for endogenous molecules like N-acetylaspartate and dopamine.

Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex

The paper reports the cryo-ET structure of the luminal ring of the Xenopus laevis nuclear pore complex and identifies key structural features confirmed by cryo-EM.

Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak

This study estimates the basic reproduction number (R0) of 2019-nCoV in China during the early outbreak phase using exponential growth modeling and serial intervals from similar coronaviruses.

Myeloid cell mPGES-1 mediates inflammatory pain hypersensitivity in mice.

This study shows that myeloid cell mPGES-1 is the main source of PGE2 in inflammatory pain hypersensitivity in mice, suggesting it as a target for new pain therapies.

Integrin β3, a RACK1 interacting protein, is required for porcine reproductive and respiratory syndrome virus infection and NF-κB activation in Marc-145 cells

This study identifies integrin β3 as a RACK1-interacting protein essential for PRRSV infection and NF-κB activation in Marc-145 cells, revealing a positive feedback loop involving NF-κB and ITGB3/RACK1.

Developing an endogenous quorum-sensing based CRISPRi circuit for autonomous and tunable dynamic regulation of multiple targets in industrial Streptomyces

This paper develops an endogenous quorum-sensing based CRISPRi circuit (EQCi) to dynamically regulate multiple targets in Streptomyces, achieving higher rapamycin titers without affecting cell growth.

A Genetically Encoded Fluorescent Sensor Enables Real-time Detection of the Intracellular GTP:GDP Ratio

This paper introduces GNEPS, a fluorescent sensor that detects intracellular GTP:GDP ratios in real-time, showing its utility in monitoring metabolic changes across cell types and organelles.

The electrically conductive pili of Geobacter soli

This paper investigates the role of electrically conductive pili in Geobacter soli by deleting the pilA gene and shows that these pili are required for extracellular electron transfer, while heterologous expression in G. sulfurreducens reduces c-type cytochrome content and EET capacity.

Development of the yeast Saccharomyces cerevisiae as a biosensor for the toxicity detection of toxic substances

This paper develops a yeast biosensor to detect chlorothalonil and heavy metals toxicity, showing improved sensitivity through optimized culture conditions and morphological, ROS, DNA, and caspase 3 activity analysis.

ACPT gene is inactivated in mammalian lineages that lack enamel and teeth

The paper identifies ACPT gene inactivation in toothless and enamel-less mammals and estimates its inactivation times across different lineages.