J. Pan

Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs its Signaling Pathways in Liver and Adipose Tissue in Mice

This study shows spinal cord injury reduces FGF21 and adiponectin levels and impairs their signaling pathways in mice, contributing to metabolic dysfunction.

Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2

The paper identifies germline-biased neutralizing antibodies against SARS-CoV-2 and shows that affinity gains do not always correlate with neutralization potency.

Germline Selection by Meiosis Defends the Transmission of defective Mitochondria with mtDNA variants

The paper investigates mtDNA variants in human polar bodies and mouse oocytes, showing meiotic selection removes defective mitochondria.

Temperature and species-dependent regulation of browning in retrobulbar fat.

This study shows that retrobulbar fat in mice can be brown or white depending on temperature and species, with potential thermogenic function.

A Prediction Tool for Plaque Progression Based on Patient-specific Multi-Physical Modeling

This paper develops a prediction tool for atherosclerotic plaque progression using patient-specific multi-physical modeling and microenvironmental indicators to differentiate stable from unstable plaques.

MicroRNA775 Promotes Intrinsic Leaf Size and Reduces Cell Wall Pectin Level via a Target Galactosyltransferase in Arabidopsis

This study identifies miR775 as a regulator of leaf size in Arabidopsis by silencing GALT9, a galactosyltransferase that affects cell wall pectin levels and elasticity.

The PIF1-MIR408-Plantacyanin Repression Cascade Regulates Light Dependent Seed Germination

The paper identifies a PIF1-MIR408-PLC repression cascade that links light-induced PIF1 degradation to hormonal changes, regulating seed germination in Arabidopsis.

Development of follicular dendritic cells in lymph nodes depends on retinoic acid mediated signaling

This study shows retinoic acid signaling is essential for generating follicular dendritic cells in lymph nodes, while blocking lymphotoxin signaling prevents fibroblastic reticular cell development.

Functional Exploration of Heterotrimeric Kinesin-II in IFT and Ciliary Length Control in Chlamydomonas

This study investigates the functional differences of kinesin-II in Chlamydomonas, showing that changes in IFT velocity have a limited effect on ciliary length.

Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

A molecular map of lymph node blood vascular endothelium at single cell resolution

The paper maps the molecular diversity of lymph node blood vascular endothelial cells at single-cell resolution, identifying novel subsets and their roles in immune cell recruitment and vascular homeostasis.

FLS2 is a CDK-like kinase that directly binds IFT70 and is required for proper ciliary disassembly in Chlamydomonas

An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.

Chemokine receptor 2-targeted molecular imaging in pulmonary fibrosis

PET imaging of CCR2+ cells in lung fibrosis identifies therapeutic response in mouse models and shows perifibrotic signal in IPF patients.

Continuous detection of glucose and insulin in live animals

This paper develops a biosensor capable of continuously measuring multiple analytes in live animals with high sensitivity and temporal resolution, demonstrating its use for glucose and insulin detection in diabetic rats.

The socioeconomic burden of severe mental disorder in China, 2014-2017: a prevalence study

This study estimates the economic burden of severe mental disorder in China from 2014-2017 using prevalence-based methods, finding substantial direct and indirect costs.

Highly diverse Asgard archaea participate in organic matter degradation in coastal sediments

This study identifies a new Asgard archaeal phylum, Gerdarchaeota, and shows their role in organic matter degradation in coastal sediments through genomic and transcriptomic analysis.

Lineage-Specific Epigenomic and Genomic Activation of the Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

The paper identifies lineage-specific activation of HNF4A in gastrointestinal adenocarcinomas through epigenomic and genomic analysis, revealing its role in promoting cancer proliferation.

Cryo-EM structure of full-length HIV-1 Env bound with the Fab of antibody PG16

The paper determines the cryo-EM structure of HIV-1 Env bound with antibody PG16 Fab, showing it stabilizes a closed conformation similar to SOSIP structures.

Genome and community-level interaction insights on wide carbon utilizing and element cycling function of Hydrothermarchaeota from hydrothermal sediment

This study analyzes metagenome-assembled genomes of Hydrothermarchaeota to reveal their versatile carbon and element cycling functions and community interactions in hydrothermal sediments.

Expression of endoplasmic reticulum mannosyl-oligosaccharide α1, 2-mannosidase regulates tumorigenicity of prostate cancer cells

This study shows that overexpression of MAN1B1 in prostate cancer cells reduces migration and promotes EMT phenotype.

Epitope containing short peptides capture distinct IgG serodynamics that enable DIVA for live-attenuated vaccines

The paper develops a DIVA strategy using epitope-containing short peptides (ECSPs) to differentiate vaccinated from infected animals, showing distinct IgG serodynamics that enable effective monitoring.

Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines

The paper describes updates to the Project Achilles processing pipeline for CRISPR screens in cancer cell lines, including quality control improvements and dependency score calculations.

Fecal microbiota as a non-invasive biomarker to predict the tissue iron accumulation in intestine epithelial cells and liver

This study identifies key gut bacteria correlated with systemic iron levels using a murine model and bioinformatic tools, establishing a non-invasive prediction model for iron-related diseases.

Response of soil microbial communities to alpine meadow degradation severity levels in the Qinghai-Tibet Plateau

This study examines how soil microbial communities change with alpine meadow degradation severity on the Qinghai-Tibet Plateau, finding shifts in bacterial and fungal phyla and associations with soil and plant properties.