J. Wang

CAMKV Kinase Signaling Is a Novel Therapeutic Avenue with Prognostic Relevance in Neuroblastoma

This study identifies CAMKV kinase signaling as a critical driver of neuroblastoma growth and shows it as a potential therapeutic target and prognostic marker.

Ultrastructure expansion microscopy (U-ExM) of mouse and human kidneys for analysis of subcellular structures

This paper describes a U-ExM protocol for analyzing subcellular structures in mouse and human kidney tissues with high detail using conventional microscopy.

Comparative genomics illuminates adaptive evolution of DVNP with lifestyle and with loss of histone H1 in dinoflagellates

This study investigates the evolutionary trajectory of DVNP in dinoflagellates, linking its domestication to the loss of histone H1 and lifestyle adaptation.

The nanoscale organization of the Nipah virus fusion protein informs new membrane fusion mechanisms.

This study uses single-molecule microscopy to show NiV-F forms nanoclusters on membranes, which promote fusion by enabling interactions with the NiV-G/receptor complex.

In a Canine Model of Septic Shock, Cardiomyopathy Occurs Independent of Catecholamine Surges and Cardiac Microvascular Ischemia

This study shows that cardiac dysfunction in septic shock occurs without high catecholamine levels or microvascular ischemia, and epinephrine infusions cause prolonged microvascular perfusion issues.

Cardiac Magnetic Resonance Studies in a Large Animal Model that Simulates the Cardiac Abnormalities of Human Septic Shock

This study uses cardiac magnetic resonance imaging in a canine sepsis model to show that ventricular wall edema and structural changes, not preload or afterload, explain differences in cardiac function and survival outcomes during sepsis.

Intermittent energy restriction inhibits tumor growth and enhances paclitaxel response in a transgenic mouse model of endometrial cancer

This study shows that intermittent energy restriction (IER) reduces tumor growth and improves paclitaxel response in a mouse model of endometrial cancer compared to low-fat diet.

SlWRKY80 recruits SlHDA1 to regulates the tomato fruit ripening and color transformation

This study identifies SlWRKY80's role in tomato fruit ripening and color change by regulating SlSGR1 and SlPSY1 through recruitment of SlHDA1.

Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through multiple mechanisms

This study investigates how N354 glycosylation in the SARS-CoV-2 spike protein affects viral fitness and human adaptation through multiple mechanisms.

In-silico Drug Repurposing pipeline for Epilepsy: Integrating Deep Learning and Structure-based Approaches

This paper develops an in-silico drug repurposing pipeline for epilepsy using deep learning and structure-based methods, identifying potential drugs with high binding affinity for epilepsy-related targets.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

Ligand supplementation restores the cancer therapy efficacy of an antirheumatic drug auranofin from serum inactivation

This study shows that adding thiols to auranofin restores its anticancer activity by modulating albumin-gold binding and enhancing therapeutic efficacy.

Declining reservoir elevations following a two-decade drought increase water temperatures and non-native fish passage facilitating a downstream invasion

The paper models how declining reservoir levels and warming temperatures in the Colorado River facilitated non-native smallmouth bass invasion and reproduction.

LRG1 promotes atherosclerosis by activating macrophages

This study identifies LRG1 as a pro-inflammatory factor in atherosclerosis by promoting macrophage M1 polarization through ERK and JNK pathways, and shows that LRG1 inhibition reduces atherosclerosis progression.

Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma

This study shows copper drives metabolic remodeling and progression in clear cell renal cell carcinoma by coordinating bioenergy, biosynthesis, and redox homeostasis.

Sequence-Dependent Conformational Transitions of Disordered Proteins During Condensation

This study investigates how sequence patterns in intrinsically disordered proteins affect their conformational transitions during condensation using a polyampholyte model.

Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics

The paper uses spatial transcriptomics and proteomics to identify claudin-4 as a theranostic target in pancreatic cancer, showing its increased expression and suitability for molecular imaging.

CRISPR-repressed toxin-antitoxin provides population-level immunity against diverse anti-CRISPR elements

The paper identifies a CRISPR-repressed toxin that provides population-level immunity against diverse anti-CRISPR elements by expelling them through abortive infection-like effects.

Fish Blood Response to Ash-Induced Environmental Alkalinization, and their Implications to Wildfire-Scarred Watersheds

This study shows that ash from wildfires increases water pH, causing rapid physiological stress in Chinook salmon, with greater effects at higher temperatures.

Metabolomics unveiled the impact of alterations in nucleotide glucose metabolism on palmitic acid-induced TLR4 activation in THP-1 macrophages

This study uses metabolomics to show that palmitic acid alters N-glycosylation-related metabolites in THP-1 macrophages, linking them to TLR4 activation and inflammation.

STING Licensing of Type I Dendritic Cells Potentiates Antitumor Immunity

A 'shock-and-lock' nanoparticle agonist activates STING in type 1 conventional dendritic cells to enhance antitumor immunity with associated biomarkers.

Cryo-EM structure and biochemical analysis of human chemokine receptor CCR8

The paper determines the cryo-EM structure of ligand-free human CCR8-Gi complex and identifies key residues for agonist recognition.

Multi-Omics Analysis Of Antiviral Interactions Of Elizabethkingia anophelis And Zika Virus

This study investigates the antiviral interactions between Elizabethkingia anophelis and Zika virus using multi-omics analysis, revealing attenuated viral replication and altered metabolic pathways.

The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis

This study shows that Zbtb24 regulates B1 cell differentiation via heme synthesis, leading to impaired antibody production in T-cell independent responses.

Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability

This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.

Deep3DSIM: Super-resolution imaging of thick tissue using 3D structured illumination with adaptive optics

This paper introduces Deep3DSIM, an upright 3D-SIM system with adaptive optics for deep tissue imaging, achieving high-quality imaging up to 130 micrometers in Drosophila brain.

YAP1 status defines two intrinsic subtypes of LCNEC with distinct molecular features and therapeutic vulnerabilities

CDRxAbs: Antibody Small-Molecule Conjugates with Computationally Designed Target-Binding Synergy

This paper introduces CDRxAbs, a new class of antibody-small-molecule conjugates designed to enhance target binding affinity and specificity through computational protein design.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

This study shows that inhibiting OGT activates type I interferon-dependent antitumor immunity by enhancing the cGAS-STING pathway through genomic instability.