Z. Jiang

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance anti-HIV activity in vitro

This study develops allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv, showing enhanced anti-HIV activity in vitro compared to autologous CAR-T cells.

Barley stripe mosaic virus γb protein targets thioredoxin h-type 1 to dampen SA-mediated antiviral defenses

The paper shows that BSMV γb protein targets NbTRXh1 to reduce its reductase activity, impairing SA defense gene expression and enhancing viral movement.

Dissolvable microgel-templated macroporous hydrogels for controlled cell assembly

This paper develops a method to create cell-laden macroporous hydrogels using dissolvable microgels, enabling controlled cell assembly and secretion of growth factors.

THEMIS is a priming substrate of non-receptor tyrosine phosphatase PTPN6/SHP1 and plays dual roles during T cell development

This study identifies THEMIS as a substrate of SHP1 and shows it has phosphorylation-dependent and -independent roles in T cell development.

Effects of sub-lethal single, simultaneous, and sequential abiotic stresses on phenotypic traits of Arabidopsis thaliana

This study examines how sub-lethal abiotic stresses affect 12 phenotypic traits in Arabidopsis thaliana, finding additive and interactive effects across different stress combinations and accessions.

FoQDE2-dependent milRNA promotes Fusarium oxysporum f. sp. cubense virulence by targeting a glycosyl hydrolase coding gene at transcriptional level

Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

Lin28a rejuvenates muscle stem cells via mitochondrial optimization

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

3D observation of large-scale subcellular dynamics in vivo at the millisecond scale

This paper introduces a method to observe 3D subcellular dynamics in vivo at high resolution and speed, demonstrating its application in various biological systems.

Nosocomial Pseudomonas aeruginosaregulates alginate biosynthesis and Type VI secretion system during adaptive and convergent evolution for coinfection in critically ill COVID-19 patients

This study investigates how Pseudomonas aeruginosa adapts and evolves during coinfection with COVID-19, showing it overexpresses alginate and reduces Type VI secretion system to enhance biofilm formation and suppress virulence.

An angiosperm NLR atlas reveals that NLR gene reduction is associated with ecological specialization and signal transduction component deletion

LncRNA SNHG1 suppresses LPS-induced acute lung injury by regulating miR-421/TIMP3 axis

This study identifies SNHG1 as a regulator of LPS-induced acute lung injury by modulating the miR-421/TIMP3 axis in A549 cells.

TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

This study identifies TRPM7's role in synaptic vesicle endocytosis and short-term synaptic depression in neurons.

Profiles of Expression pattern and tissue distribution of host defense peptides genes in different chicken (Gallus gallus) breeds related to body weight

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

HYD3, a conidial hydrophobin of the fungal entomopathogen Metarhizium acridum induces the immunity of its specialist host locust

This study shows that the hydrophobin HYD3 from the specialist fungal pathogen Metarhizium acridum activates immunity in its host locust but not in non-host insects.

Aminoglycoside antibiotics inhibit mycobacteriophage infection

This study shows that certain aminoglycoside antibiotics inhibit mycobacteriophage infection while others do not, suggesting a mechanism involving the amino sugar group.

Antimicrobial emulsifier - glycerol monolaurate impacts gut micobiome inducing distinct effects on metabolic syndrome in low-fat diet fed mice

This study investigates how different doses of glycerol monolaurate (GML) affect gut microbiota and metabolic syndrome in low-fat diet-fed mice, showing high-dose GML reduces MetS through microbiota changes.

Nanoparticle-mediated microRNA-145 Delivery for Vascular Smooth Muscle Cell Phenotype Modulation and Atherosclerosis Treatment

This study develops miR-145-loaded nanoparticles to target VSMC phenotype switching and atherosclerosis, showing reduced plaque growth and restored contractile markers in vitro and in mice.

Chromatin State Dynamics Confers Specific Therapeutic Strategies in Enhancer Subtypes of Colorectal Cancer

This study identifies enhancer subtypes in colorectal cancer through epigenomic analysis and proposes targeted therapeutic strategies based on these subtypes.

Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer

The paper describes a genetically adapted Pseudomonas aeruginosa small colony variant causing persistent bacterial coinfection in a COVID-19 patient, showing enhanced biofilm formation and quorum sensing.

Insights into the catalytic properties of the mitochondrial rhomboid protease PARL

This study investigates the catalytic properties of the mitochondrial rhomboid protease PARL using in vitro assays, revealing substrate preferences and activity enhancements under specific conditions.

Integrative Proteomic Analysis of Posttranslational Modification in The Inflammatory Response

This study integrates proteomic data from human and mouse macrophages to analyze posttranslational modifications in the inflammatory response, identifying PTM crosstalk and novel inflammatory proteins.

Numerical Model for Formation and Evolution of the Bleb

This paper develops a numerical model to simulate bleb formation and evolution in cells, showing how parameters affect bleb size and shape.

Role of Inflammasome-independent Activation of IL-1β by the Pseudomonas aeruginosa Protease LasB

This study identifies that the Pseudomonas aeruginosa protease LasB directly activates IL-1β independently of inflammasomes, contributing to lung inflammation and pathology during infection.

Pattern-recognition receptors are required for NLR-mediated plant immunity

This study shows that pattern-recognition receptors (PRRs) are essential for NLR-mediated immunity in plants, revealing a unified model where PTI supports ETI during bacterial infection.

On the role of transcription in positioning nucleosomes

This study uses simulations to show how transcription affects nucleosome positioning differently in yeast and mouse, revealing enzyme competition and polymerase effects.

Interpretable machine learning framework reveals novel gut microbiome features in predicting type 2 diabetes

The paper develops an interpretable machine learning framework to identify gut microbiome features predictive of type 2 diabetes, validated across multiple cohorts and linked to metabolic outcomes.

Brassinosteroids Suppress Ethylene Biosynthesis via Transcription Factor BZR1 in Pear and Apple Fruit

BR-activated BZR1 suppresses ACO1 activity and expression of ACO1 and ACS1a, reducing ethylene production during pear and apple fruit ripening.

The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for human complex diseases

This study identifies host genetic variants associated with gut microbiome and examines causal relationships between gut microbiome and human complex diseases, revealing shared and distinct microbiome features.